DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdm3 and Pou6f1

DIOPT Version :9

Sequence 1:	NP_001188885.2	Gene:	pdm3 / 35813	FlyBaseID:	FBgn0261588	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_006520671.1	Gene:	Pou6f1 / 19009	MGIID:	102935	Length:	610	Species:	Mus musculus

Alignment Length:	829	Identity:	238/829 - (28%)
Similarity:	316/829 - (38%)	Gaps:	305/829 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 GKSKTAKGGSSGNGSGGSSANSGTSSAQQQQQPDNPSSSSSPHHPLSASSLANVLAAATASPPPS 558
            |....|.|||.   |||....||.:.|          .|..|.|  ||.:....|.....||.|:
Mouse    45 GLESVAAGGSQ---SGGPVEASGPAEA----------GSCDPDH--SAEATVKSLPGVPPSPAPA 94

  Fly   559 L----QAPPASAQMPQLILASGQLVQGVQGAQLLIPTAQGIAVQTILTIPVSPQIPTTEQFLPNA 619
            :    |||    ..|             |.:|.|.|          |.:..:||:.|.|
Mouse    95 IATFNQAP----SQP-------------QASQTLTP----------LAVQAAPQVLTQE------ 126

  Fly   620 FGAFASYQQQQQQQQQQRDLLPPSLAALQHATALPQLAQTPTNLLKPNLFSTGVQQLLTALHPEL 684
                                   |||.:.....:|  |.|.|   :|.|...|:
Mouse   127 -----------------------SLATVLTGVMVP--AGTVT---QPLLIPIGI----------- 152

  Fly   685 FAAAAATHQQQQQQQQQQVQQQREREREREREREREREREREQHLGIGHLPHSHLAADLRRSAER 749
                           ..||..|                    |.|.:..:|.:.:||
Mouse   153 ---------------TGQVAGQ--------------------QGLAVWTIPTATVAA-------- 174

  Fly   750 SP--TAGSPTGGSPGLAAKGPQPPPPGAAFLLQQQLHIKPETQTHLHHHLQTQSTSAVSSTLPQI 812
            .|  ||.|||||:       .:||..|                        .|:.:.:::.||
Mouse   175 LPGLTAASPTGGT-------FKPPLAG------------------------LQAAAVLNTALP-- 206

  Fly   813 SLRHPDELTAPQMDLKPLELS--ASTSPPAPPPRHHFGHSLRGSSTVSPKHSPQGRMGGSGGSTT 875
                     .|.....|::.|  |...|||.|               .|....|..:      .|
Mouse   207 ---------TPVQAAPPIQASSPAQPRPPAQP---------------QPLFQTQPLL------QT 241

  Fly   876 TGMNLSQHHERHDRLERLERQERHERRSHTPTATATRASVSSSSSAGHHGGSLPSGRLSPPS--S 938
            |...|.|                       |||....|....:..|.......|:|....|.  |
Mouse   242 TPAILPQ-----------------------PTAATVAAPTPKTVDATPQITVQPAGFAFSPGIIS 283

  Fly   939 APSNSAANSISDRGYTSPLFRTHSPQGHALSLGGSPRLERDYLGNGPSSGTATSTSSCGAPTAAG 1003
            |.|......|.....|:|:.....|....:|.......:...:|..|   ...:::|...|..|.
Mouse   284 AASLGGQTQILGSLTTAPVITNTIPSMPGISSQILTNAQGQVIGALP---WVVNSASVATPAPAQ 345

  Fly  1004 S----SATANVLSSINRLNASNGELTITKSLGAPTATATRASSASPRDDSPGPGPSTSSVSHMQP 1064
            |    :.|..:|     |||....:....|...|...|.|      :.::| ..|:.|.|..:||
Mouse   346 SLQVQAVTPQLL-----LNAQGQVIATLASSPLPQPVAVR------KPNTP-ESPAKSEVQPIQP 398

  Fly  1065 LK---------------LSPSSR-------SEPPHLSPNGNDNDNDLLMDSPNEPTINQATTNVV 1107
            .:               |.||:.       ||.|.:|.         |:..|:.|::::
Mouse   399 TQAVPQPAVILTSPTPALKPSAATPIPITCSETPTVSQ---------LVSKPHTPSLDE------ 448

  Fly  1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSSALAAQMYAAQLSTQQQ 1172
            |||:|:||:||||.||:||||||||||||||||:.||||||||||||
Mouse   449 DGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAIC------------------ 495

  Fly  1173 NMFEKLDITPKSAQKIKPVLERWMKEAEESHWNRYKSGQNHLTDYIGVEPSKKRKRRTSFTPQAL 1237
             .|||||||||||||:|||||:|:.|||    .|.:.||.:|.:::|.||||||||||||||||:
Mouse   496 -RFEKLDITPKSAQKLKPVLEKWLMEAE----LRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAI 555

  Fly  1238 ELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNTVRM 1286
            |.|||:||:|..|:|.|||.:|.:|.|:|||:|:||||:||.||||.::
Mouse   556 EALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKL 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm3	NP_001188885.2	Pou	1108..1200	CDD:304656	60/91 (66%)
pdm3	NP_001188885.2	Homeobox	1228..1281	CDD:278475	34/52 (65%)
Pou6f1	XP_006520671.1	PHA03247	<48..425	CDD:223021	118/607 (19%)
		Pou	448..522	CDD:389985	60/98 (61%)
		Homeobox	546..600	CDD:365835	35/53 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8493
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004074
OrthoInspector	1	1.000	-	-		otm42420
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4954
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.900