DRSC/TRiP Functional Genomics Resources

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Protein Alignment pdm3 and Pou4f2

DIOPT Version :10

Sequence 1:NP_001188885.2 Gene:pdm3 / 35813 FlyBaseID:FBgn0261588 Length:1292 Species:Drosophila melanogaster
Sequence 2:NP_620394.2 Gene:Pou4f2 / 18997 MGIID:102524 Length:411 Species:Mus musculus


Alignment Length:545 Identity:121/545 - (22%)
Similarity:187/545 - (34%) Gaps:207/545 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   783 LHIKPETQTHLHHHLQTQSTSAVSSTLPQISLRHPDELTAPQMDLKPLELSASTSPPAPPPRHHF 847
            ||::|:             .||:.|..|                       .|::|.||      
Mouse    20 LHVEPK-------------YSALHSASP-----------------------GSSAPAAP------ 42

  Fly   848 GHSLRGSSTVSPKHSPQGRMGGSGGSTTTGMNLSQHHERHDRLERLERQERHERRSHTPTATATR 912
                   |..||..|.....||.||....|                                ..|
Mouse    43 -------SASSPSSSSNAGGGGGGGGGGGG--------------------------------GGR 68

  Fly   913 ASVSSSSSAGHHGGS----------LPSGRLSPPSS------------APSNSAANSISDRGYTS 955
            :|.||||.:|..||.          ||    :|||:            |.:.:|.:.:|.    |
Mouse    69 SSSSSSSGSGGSGGGGGSEAMRRACLP----TPPSNIFGGLDESLLARAEALAAVDIVSQ----S 125

  Fly   956 PLFRTHSPQGHALSLGGSPRLERDYLGNGPSSGTATSTSSCGAPTAAGSSATANVLSSINRL--- 1017
            .....|.|.                  :.|....||..:....|..:.:|:::..:|..:.|   
Mouse   126 KSHHHHPPH------------------HSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGT 172

  Fly  1018 ---------------NASNGELTITKSLGAPTATATRASSASPRDDSPGPGPSTSSVSHMQPLKL 1067
                           .|..|||  .:.|....|....|........:|...|..::::.|....|
Mouse   173 HHHHHHHHHHHHQPHQALEGEL--LEHLSPGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAAL 235

  Fly  1068 SPS-SRSEPPHLSPNGNDNDNDLLMDSPNEPTINQATTNVVDGIDLD--EIKEFAKAFKLRRLSL 1129
            |.: :...|.|:                          ..:..:|.|  :::.||:.||.||:.|
Mouse   236 SMAHAHGLPSHM--------------------------GCMSDVDADPRDLEAFAERFKQRRIKL 274

  Fly  1130 GLTQTQVGQALSVTEGP---AYSQSAICSSALAAQMYAAQLSTQQQNMFEKLDITPKSAQKIKPV 1191
            |:||..||.||:..:.|   :.|||.||                   .||.|.::..:...:||:
Mouse   275 GVTQADVGSALANLKIPGVGSLSQSTIC-------------------RFESLTLSHNNMIALKPI 320

  Fly  1192 LERWMKEAEESHWNRYKSGQNHLTDYIGVEPSKKRKRRTSFTPQALELLNAHFERNTHPSGTEIT 1256
            |:.|::|||:||  |.|..:..|  :.|.|   |:::|||........|.|:|.....||..:|.
Mouse   321 LQAWLEEAEKSH--REKLTKPEL--FNGAE---KKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIA 378

  Fly  1257 GLAHQLGYEREVIRIWFCNKRQALK 1281
            .:|.:|..::.|:|:||||:||..|
Mouse   379 AIAEKLDLKKNVVRVWFCNQRQKQK 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pdm3NP_001188885.2 Pou 1108..1200 CDD:473999 30/96 (31%)
Homeodomain 1226..1282 CDD:459649 20/56 (36%)
Pou4f2NP_620394.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..95 24/133 (18%)
Required for transcriptional activation. /evidence=ECO:0000269|PubMed:15733064 93..239 30/173 (17%)
POU-IV box 112..121 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..190 3/35 (9%)
Nuclear speckle targeting signal. /evidence=ECO:0000250|UniProtKB:Q12837 173..187 0/13 (0%)
ACR_tran <200..>288 CDD:481531 25/113 (22%)
Required for DNA-binding and transcriptional repression. /evidence=ECO:0000269|PubMed:15733064, ECO:0000269|PubMed:7852360 240..411 62/216 (29%)
POU 252..329 CDD:197673 30/95 (32%)
Homeodomain 348..404 CDD:459649 20/56 (36%)

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