DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdm3 and POU6F2

DIOPT Version :9

Sequence 1:	NP_001188885.2	Gene:	pdm3 / 35813	FlyBaseID:	FBgn0261588	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001357888.1	Gene:	POU6F2 / 11281	HGNCID:	21694	Length:	720	Species:	Homo sapiens

Alignment Length:	941	Identity:	279/941 - (29%)
Similarity:	375/941 - (39%)	Gaps:	331/941 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 HPHHGHQHHH---------HHPATAAALASLQGLAASVFNSPL-------NLSVGGEPVATTG-- 481
            :||...|..|         ....|..|:.....:.|...:.||       |..:.||..|.|.
Human     5 NPHSPFQRQHMMDCYLSAQQDTGTMQAVIGQDPMIAGQVSKPLLSVRSEMNAELRGEDKAATSDS 69

  Fly   482 ----PSVAPTSPTHNGGKSKTAK-GGSSGNGSGGSSANSGTSSAQQQQQPDNPSSSSSPHHPLSA 541
                |.:||..  .|..:...:| .|:.||   .:.::.||.. |.|....:|.....|...|:|
Human    70 ELNEPLLAPVE--SNDSEDTPSKLFGARGN---PALSDPGTPD-QHQASQTHPPFPVGPQPLLTA 128

  Fly   542 SSLANVLAAATASPPPSLQAPPASAQMPQLIL----ASGQLVQGVQGAQLLIPTA-----QGI-- 595
            ..||:.:|......||:|..|         ||    .:||| .|.||..|.:|||     ||:
Human   129 QQLASAVAGVMPGGPPALNQP---------ILIPFNMAGQL-GGQQGLVLTLPTANLTNIQGLVA 183

  Fly   596 --AVQTILTIPVSPQIPTTEQFLPNAFGAFASYQQQQQQQQQQRDLLPPSLAALQHATALPQLAQ 658
              |...|:|:|:. .:..|..............||||||||||.   |||
Human   184 AAAAGGIMTLPLQ-NLQATSSLNSQLQQLQLQLQQQQQQQQQQP---PPS--------------- 229

  Fly   659 TPTNLLKPNLFSTGVQQLLTALHPELFAAAAATHQQQQQQQQQQVQQQRERERERERERERERER 723
                               |..||:      ...|...|.|||.:|
Human   230 -------------------TNQHPQ------PAPQAPSQSQQQPLQ------------------- 250

  Fly   724 EREQHLGIGHLPHSHLAADLRRSAERSPTAGSPTGGSPGLAAKGPQPPPPGAAFLLQQ------Q 782
                                       ||.              ||.|||.:    ||      |
Human   251 ---------------------------PTP--------------PQQPPPAS----QQPPAPTSQ 270

  Fly   783 LHIKPETQTHL-HHHLQTQSTSAVSSTLPQISLRHPDELTAPQMDLKPLELSASTSPPAPPPRHH 846
            |...|:.|.|. |.|.|.|:                          :|.....|:|||..|.:..
Human   271 LQQAPQPQQHQPHSHSQNQN--------------------------QPSPTQQSSSPPQKPSQSP 309

  Fly   847 FGHSLRGSSTVSPKHSPQGRMGGSGGSTTTGMNLSQHHERHDRLERLERQERHERRSHTPTATAT 911
             ||.|  .|.::|.:..|                               ...:...|....|.|.
Human   310 -GHGL--PSPLTPPNPLQ-------------------------------LVNNPLASQAAAAAAA 340

  Fly   912 RASVSSSSSAGHHGGSLP--SGRLSP-------------PSSAPSNSAANSISDRGYTSPLFRTH 961
            .:|::||.:.|:...||.  :|:|..             |:..||:.||:..... ...|:
Human   341 MSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGL-QVQPI---- 400

  Fly   962 SPQGHALSLGGSPRLERDYLGNG--PSSGTATSTSSCGAP---------TAAGSSATANVLSSIN 1015
            :||   |......::....:||.  |...|...|.|...|         |:.|.:|     |..|
Human   401 TPQ---LLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSVGQAA-----SQGN 457

  Fly  1016 RLNASNGELTITKSLGAPTATATRASSASPRDDSPGPGPSTSSVSHMQPLKLSPSSRSEPPHLSP 1080
            .|:.::.:.::::|   |...|:.:||:|         .|:|::|..|
Human   458 LLHLAHSQASMSQS---PVRQASSSSSSS---------SSSSALSVGQ----------------- 493

  Fly  1081 NGNDNDNDLLMDSPNEPTINQATTNVVDGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEG 1145
                     |:.:|      |.....|||::|:||:|||||||:|||||||||||||||||.|||
Human   494 ---------LVSNP------QTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEG 543

  Fly  1146 PAYSQSAICSSALAAQMYAAQLSTQQQNM-----------------FEKLDITPKSAQKIKPVLE 1193
            |||||||||...:....:......|:..:                 |||||||||||||||||||
Human   544 PAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLE 608

  Fly  1194 RWMKEAEESHWNRYKSGQNHLTDYIGVEPSKKRKRRTSFTPQALELLNAHFERNTHPSGTEITGL 1258
            |||.|||.    |:::|..:||::||.||||||||||||||||||:||||||:||||||.|:|.:
Human   609 RWMAEAEA----RHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEI 669

  Fly  1259 AHQLGYEREVIRIWFCNKRQALKNTVRMMSK 1289
            |.:|.|:|||:|:||||||||||||::.:.:
Human   670 AEKLNYDREVVRVWFCNKRQALKNTIKRLKQ 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm3	NP_001188885.2	Pou	1108..1200	CDD:304656	65/108 (60%)
pdm3	NP_001188885.2	Homeobox	1228..1281	CDD:278475	40/52 (77%)
POU6F2	NP_001357888.1	Pou	506..615	CDD:389985	65/108 (60%)
POU6F2	NP_001357888.1	Homeobox	639..693	CDD:365835	41/53 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6997
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004074
OrthoInspector	1	1.000	-	-		otm40354
orthoMCL	1	0.900	-	-		OOG6_109259
Panther	1	1.100	-	-	LDO	PTHR11636
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4954
SonicParanoid	1	1.000	-	-		X5977
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.930