DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdm3 and pou6f2

DIOPT Version :9

Sequence 1:	NP_001188885.2	Gene:	pdm3 / 35813	FlyBaseID:	FBgn0261588	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_012820956.1	Gene:	pou6f2 / 100489745	XenbaseID:	XB-GENE-853682	Length:	682	Species:	Xenopus tropicalis

Alignment Length:	883	Identity:	268/883 - (30%)
Similarity:	363/883 - (41%)	Gaps:	288/883 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 VFNSPLNLSVGGEPVATTG------PSVAPTSPTHNGGKSKTAK-GGSSGNGSGGSSANSGTSSA 520
            :..|.:|....||..|.|.      |.:||..  .|.|:...:| .|:.||   ..||.|||:..
Frog    12 LLRSEMNAESRGEDKAATSDSELNEPLLAPVE--SNDGEDTPSKLFGARGN---SVSAESGTNDL 71

  Fly   521 QQQQQPDNPSSSSSPHHPLSASSLANVLAAATASPPPSLQAPPASAQMPQLIL----ASGQLVQG 581
            .|..| .:|.....|...|:|..||:.:|.......|:|..|         ||    .:||| .|
Frog    72 HQPNQ-THPGFPLGPQPLLAAQQLASAVAGVMPGGGPALNQP---------ILIPFNMAGQL-GG 125

  Fly   582 VQGAQLLIPTA-----QGI----AVQTILTIP---------VSPQIPTTEQFLPNAFGAFASYQQ 628
            .||..|.:|||     ||:    |...|:|:|         ::.|:...:............:.|
Frog   126 QQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNTQLQQLQHLQQLQHHHHHHHHQ 190

  Fly   629 QQQQQQQQRDLLPPSLAALQHATALPQLAQTPTNLLKPNLFSTGVQQLLTALHPELFAAAAATHQ 693
            |||||||.:.......:.:||    .|.:|.|:..::|       ||                .|
Frog   191 QQQQQQQGQQHHQQQQSTVQH----QQSSQQPSQQIQP-------QQ----------------SQ 228

  Fly   694 QQQQQQQQQVQQQREREREREREREREREREREQHLGIGHLPHSHLAADLRRSAERSPTAGSPTG 758
            ||.|.||||.|||.:...:.:.:                           :.|.:|:.::.....
Frog   229 QQNQHQQQQSQQQSQTPTQNQNQ---------------------------QASCQRNSSSPQKPN 266

  Fly   759 GSPGLAAKGPQPPPPGAAFLLQQQLHIKPETQTHLHHHLQTQSTSAVSSTLPQISLRHPDELTAP 823
            .|||.....|..||                                                ...
Frog   267 QSPGHGLPSPITPP------------------------------------------------NPL 283

  Fly   824 QMDLKPLELSASTSPPAPPPRHHFGHSLRGSSTVSPKHSPQGRMGGSGGSTTTGMNLSQHHERHD 888
            ||...||...|:.:..|                        ..||...||...|..||.
Frog   284 QMVNNPLANQAAAAAAA------------------------AAMGSIAGSQAFGNALSS------ 318

  Fly   889 RLERLERQERHERRSHTPTATATRASVSSSSSAGHHGGSLPSGRLSP--PSSAPSNSAANSISDR 951
             |:.:..|            ..|.|.       |...|::|   |.|  .||..:..||..:..:
Frog   319 -LQGVTGQ------------LVTNAQ-------GQIIGTIP---LMPNAMSSNQATGAAQGLQVQ 360

  Fly   952 GYTSPLFRTHSPQGHALSLGGSPRLERDYLGNG--PSSGTATSTSSCGAP------TAAGSSATA 1008
            ..|..|..  :.||..::         ..:||.  |...|...|.|...|      ||...|:.|
Frog   361 PITPQLLT--NAQGQIIA---------TVIGNQILPVINTQGITLSPIKPGQQLHQTAQTQSSQA 414

  Fly  1009 NVLSSINRLNASNGELTITKSLGAPTATATRASSASPRDDSPGPGPSTSSVSHMQPLKLSPSSRS 1073
            .  |..|.|:.:..:.::::|   |...|:.:||:|         .|:|::|..|
Frog   415 T--SQANLLHLAQNQASMSQS---PVRQASSSSSSS---------SSSSALSVGQ---------- 455

  Fly  1074 EPPHLSPNGNDNDNDLLMDSPNEPTINQATTNVVDGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQ 1138
                            |:.:|      |..:..|||::|:||:|||||||:||||||||||||||
Frog   456 ----------------LVSNP------QTASGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQ 498

  Fly  1139 ALSVTEGPAYSQSAICSSALAAQMYAAQLSTQQQNM-----------------FEKLDITPKSAQ 1186
            |||.||||||||||||...:....:......|:..:                 ||||||||||||
Frog   499 ALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQ 563

  Fly  1187 KIKPVLERWMKEAEESHWNRYKSGQNHLTDYIGVEPSKKRKRRTSFTPQALELLNAHFERNTHPS 1251
            ||||||||||.|||.    |:::|..:||::||.||||||||||||||||||:||||||:|||||
Frog   564 KIKPVLERWMAEAEA----RHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPS 624

  Fly  1252 GTEITGLAHQLGYEREVIRIWFCNKRQALKNTVRMMSK 1289
            |.|:|.:|.:|.|:|||:|:||||||||||||::.:.:
Frog   625 GQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRIKQ 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm3	NP_001188885.2	Pou	1108..1200	CDD:304656	65/108 (60%)
pdm3	NP_001188885.2	Homeobox	1228..1281	CDD:278475	40/52 (77%)
pou6f2	XP_012820956.1	Pou	468..577	CDD:389985	65/108 (60%)
pou6f2	XP_012820956.1	Homeobox	601..655	CDD:365835	41/53 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004074
OrthoInspector	1	1.000	-	-		otm47525
Panther	1	1.100	-	-	LDO	PTHR11636
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5977
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.100