DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pdm3 and pou6f1

DIOPT Version :9

Sequence 1:	NP_001188885.2	Gene:	pdm3 / 35813	FlyBaseID:	FBgn0261588	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_012811781.1	Gene:	pou6f1 / 100126212	XenbaseID:	XB-GENE-854918	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	554	Identity:	195/554 - (35%)
Similarity:	260/554 - (46%)	Gaps:	131/554 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 PTAGSPTGGSPGLAAKGPQPPPPGAAFLLQ-QQLHIKPETQTHLHHHLQ-TQSTSAVSSTLPQIS 813
            |||...|  .|||..    .||.|..|.|. ..|.......|.|...:| .|:...|..|.|.:.
Frog   158 PTATVAT--LPGLTT----APPAGGVFKLPLANLQAASLLNTALQAPMQAAQAIQTVYQTQPALQ 216

  Fly   814 LRHPDELTAPQMDLKPLELSASTSPPAPPPRHHFGHSLRGSSTVSPKHSPQGRMGGSGGSTTTGM 878
            .: |...||.|    |:....:.||            |:|.:.|.|     |.:
Frog   217 AQ-PSLQTAVQ----PMTTLQAASP------------LQGQTAVLP-----GTL----------- 248

  Fly   879 NLSQHHERHDRLERLERQERHERRSH---TPTATATRASVSSSSSAGHHGGSLPSGRLSPPSSAP 940
                             |:..|.:|.   .|.:.....::.|::|.|.....|.|...:|
Frog   249 -----------------QKAAEPQSQITVQPASFTFNPAIISAASLGGQAQLLGSLAATP----- 291

  Fly   941 SNSAANSISD-RGYTSPLFRTHSPQGHALSLGGSPRLERDYLGNGPSSGTATSTSSCGAPTAAGS 1004
              ..||:|.. :|.||.:..  :.||..  :|..|     :|.|.|.       .:.||.|||.|
Frog   292 --IIANAIPGVQGITSQIIT--NTQGQV--IGTLP-----WLLNSPG-------ITAGAATAAVS 338

  Fly  1005 SATANVLSSIN---RLNASNGELTITKSLGAPTATATRASSASPRDDSPGPGPSTSSVSHMQPLK 1066
            :  .|::.::.   .||| .|::..|.:.......|.|..:.   .|||....|...|....|..
Frog   339 A--QNLVQTVTPQLLLNA-QGQVIATLASSPIQQGAVRKQTP---QDSPAHPKSEQQVIQPTPAI 397

  Fly  1067 LSPS---SRSEPPHLSPNGNDNDNDLLMDSPNEPTINQATTNV------VDGIDLDEIKEFAKAF 1122
            ..||   :...||..|     ....:.:.....||:.|..:..      .|||:|:||:||||.|
Frog   398 TQPSVVVANPAPPTTS-----TSTQVHISCSEPPTVGQLVSKAHSGNYDDDGINLEEIREFAKEF 457

  Fly  1123 KLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSSALAAQMYAAQLSTQQQNMFEKLDITPKSAQK 1187
            |:||||||||||||||||:.||||||||||||                   .|||||||||||||
Frog   458 KIRRLSLGLTQTQVGQALTATEGPAYSQSAIC-------------------RFEKLDITPKSAQK 503

  Fly  1188 IKPVLERWMKEAEESHWNRYKSGQNHLTDYIGVEPSKKRKRRTSFTPQALELLNAHFERNTHPSG 1252
            :|||||:|:.|||    .|.:.||.:|.:::|.||||||||||||||||:|:|||:||:|:.|:|
Frog   504 LKPVLEKWLNEAE----MRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAVEVLNAYFEKNSLPAG 564

  Fly  1253 TEITGLAHQLGYEREVIRIWFCNKRQALKNTVRM 1286
            .|||.:|.:|.|:|||:|:||||:||.||||.::
Frog   565 QEITDIAKELNYDREVVRVWFCNRRQTLKNTSKL 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm3	NP_001188885.2	Pou	1108..1200	CDD:304656	60/91 (66%)
pdm3	NP_001188885.2	Homeobox	1228..1281	CDD:278475	34/52 (65%)
pou6f1	XP_012811781.1	POU	442..516	CDD:197673	60/92 (65%)
pou6f1	XP_012811781.1	Homeobox	540..594	CDD:395001	35/53 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8382
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004074
OrthoInspector	1	1.000	-	-		otm47525
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4954
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.040