DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30371 and C1R

DIOPT Version :9

Sequence 1:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens

Alignment Length:	401	Identity:	98/401 - (24%)
Similarity:	153/401 - (38%)	Gaps:	95/401 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DNTFNLSPGTTYVESPYYPNNYPGGTSCRYKFTAPLDYY---IQVQC------------SLGIPK 74
            |.|::.:.....::....|.|.|.| ..||..|..::.|   ||..|            |....:
Human   375 DGTWHRAMPRCKIKDCGQPRNLPNG-DFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQ 438

  Fly    75 GNGQCTTDNFWL-DTEGDLLMRGAENFCGSGTLSRESLFTELVFAYISTGTKGGSFKCTLTTVKQ 138
            |...||....|. :.:|:.:.| ....||.                            .:..|:|
Human   439 GVYTCTAQGIWKNEQKGEKIPR-CLPVCGK----------------------------PVNPVEQ 474

  Fly   139 NCNCGWSATTRIANGQQAAANEFPSMAALKDVTKNQASFCGGTIVAHRYILTAAHCIY-----QV 198
            .        .||..||:|....||     ..|..|.....||.::..|:||||||.:|     ..
Human   475 R--------QRIIGGQKAKMGNFP-----WQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQ 526

  Fly   199 SRATNIVAIVGTN-----DLGNPSSSRYYQQYNIQQMIPHEQYVSDPDVN--NDIAVLITASNIQ 256
            |.|:..|.:..||     .|||         :.|:::..|..|..|...|  .|||:|...:::.
Human   527 SNASLDVFLGHTNVEELMKLGN---------HPIRRVSVHPDYRQDESYNFEGDIALLELENSVT 582

  Fly   257 WSRGVGPICLPPVGTSTPFTYDLVDVIGYGTVF--FAGPTSTSLQKINLNVVTNQDCQT--EYNN 317
            ....:.|||||...|    .||| .::||.:.|  .....:..|:.:.|.|...|.|:.  ...|
Human   583 LGPNLLPICLPDNDT----FYDL-GLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKN 642

  Fly   318 VATIYTGQMCTYDYSGTGRDSCQFDSGGPVILR---KSRQFLVGIISYGKSCAESQYPMGVNTRI 379
            ...:::..|....:....:|:||.||||...:|   ..|....||:|:|..|:..   .|..|::
Human   643 RMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRG---YGFYTKV 704

  Fly   380 TSYISWIRQKI 390
            .:|:.||::::
Human   705 LNYVDWIKKEM 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30371	NP_610370.1	CUB	24..>67	CDD:294042	12/44 (27%)
		Tryp_SPc	149..386	CDD:214473	72/255 (28%)
		Tryp_SPc	150..389	CDD:238113	73/257 (28%)
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569	2/9 (22%)
		Sushi	390..461	CDD:306569	18/72 (25%)
		Tryp_SPc	477..711	CDD:214473	72/255 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000