DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30371 and Corin

DIOPT Version :9

Sequence 1:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_058565.2	Gene:	Corin / 53419	MGIID:	1349451	Length:	1113	Species:	Mus musculus

Alignment Length:	336	Identity:	91/336 - (27%)
Similarity:	149/336 - (44%)	Gaps:	43/336 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QCSLG-------IPKGNGQCTTDNFWLDTEGDLLMRGAENFCGSGTLSRESLFTELVFAYISTGT 124
            |..||       ||...||     .||     .|....||..||      :|...||:.:.....
Mouse   797 QMGLGEPSVTKLIPGQEGQ-----QWL-----RLYPNWENLNGS------TLQELLVYRHSCPSR 845

  Fly   125 KGGSFKCTLTTVKQNCNCGWSA--TTRIANGQQAAANEFPSMAALKDVTKNQASFCGGTIVAHRY 187
            ...|..|:    ||:|....:|  ..||..|:.:....:|...:|:  ::.....||..::|.::
Mouse   846 SEISLLCS----KQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQ--SEPSGHICGCVLIAKKW 904

  Fly   188 ILTAAHCIYQVSRATNIVAIVGTNDLGNPSSSRYYQQYNIQQMIPHEQYVSDPDVNNDIAVLITA 252
            :||.|||......|.....:.|.|:|.:||.  :.|...::.::.|.:| |...|:.||:|:..:
Mouse   905 VLTVAHCFEGREDADVWKVVFGINNLDHPSG--FMQTRFVKTILLHPRY-SRAVVDYDISVVELS 966

  Fly   253 SNIQWSRGVGPICLP-PVGTSTPFTYDLVDVIGYGTVFFAGPTSTSLQKINLNVVTNQDCQTEYN 316
            .:|..:..|.|:||| |.....|.||  ..:.|:|  .........||:..:.::..:.||: |.
Mouse   967 DDINETSYVRPVCLPSPEEYLEPDTY--CYITGWG--HMGNKMPFKLQEGEVRIIPLEQCQS-YF 1026

  Fly   317 NVATIYTGQMCTYDYSGTGRDSCQFDSGGPVILRK--SRQFLVGIISYGKSCAESQYPMGVNTRI 379
            ::.||....:|....||| .|||..|||||::..:  .:..|.|:.|:|..|.......||.:.:
Mouse  1027 DMKTITNRMICAGYESGT-VDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNV 1090

  Fly   380 TSYISWIRQKI 390
            :.::.||.::|
Mouse  1091 SYFVGWIERQI 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30371	NP_610370.1	CUB	24..>67	CDD:294042	91/336 (27%)
		Tryp_SPc	149..386	CDD:214473	65/239 (27%)
		Tryp_SPc	150..389	CDD:238113	66/241 (27%)
Corin	NP_058565.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..202
		CRD_corin_1	202..331	CDD:143554
		LDLa	337..372	CDD:238060
		LDLa	374..408	CDD:238060
		Ldl_recept_a	415..445	CDD:278486
		LDLa	455..482	CDD:238060
		CRD_corin_2	522..643	CDD:143579
		Ldl_recept_a	648..682	CDD:278486
		LDLa	<695..720	CDD:238060
		LDLa	723..757	CDD:238060
		SR	758..853	CDD:214555	18/71 (25%)
		Tryp_SPc	868..1097	CDD:214473	65/239 (27%)
		Tryp_SPc	869..1100	CDD:238113	66/241 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000