DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30371 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	106/489 - (21%)
Similarity:	175/489 - (35%)	Gaps:	166/489 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YVESPYYPNNYPGGTSCRYKFTAP-LDY------------------------------------- 62
            ::.:||||:.|...|.|.:..|.| |||
  Rat   350 FLRTPYYPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYNLLCTQGQWMIQNRRLCGFRT 414

  Fly    63 ---Y--------------------------IQVQ---------------CS---LGIPKGNG--- 77
               |                          :||.               ||   |.:|..:|
  Rat   415 LQPYAERIPVVASDGITINFTSQISLTGPGVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKD 479

  Fly    78 ----------------QCTTDNFWL------DTEGDLLMRGAENFCGSGTLSRESLFTELVFAYI 120
                            ||..|:..:      |.:.|.|....|..|..|               :
  Rat   480 CPNGLDERNCVCRAMFQCQEDSTCISLPRVCDRQPDCLNGSDEEQCQEG---------------V 529

  Fly   121 STGT-----------------KGGSFKCTLTTVKQNCNCGWSA-TTRIANGQQAAANEFPSMAAL 167
            ..||                 ..|...|...:.:::|:||... ::||..|..::..|:|..|:|
  Rat   530 PCGTFTFQCEDRSCVKKPNPECDGQADCRDGSDEEHCDCGLQGPSSRIVGGAMSSEGEWPWQASL 594

  Fly   168 KDVTKNQASFCGGTIVAHRYILTAAHCIYQVSRATNIVAIVGTNDLGNPSSSRYYQQYNIQQMIP 232
            :...::   .|||.::|.|:::|||||..:.|.|:..:..|....:...|.......:.:.::..
  Rat   595 QIRGRH---ICGGALIADRWVITAAHCFQEDSMASPRLWTVFLGKMRQNSRWPGEVSFKVSRLFL 656

  Fly   233 HEQYVSDPDVNNDIAVLITASNIQWSRGVGPICLP------PVGTSTPFTYDLVDVIGYGTVFFA 291
            |..:..|.. :.|:|:|.....:.:|..|.|:|||      ..|.....|       |:|.....
  Rat   657 HPYHEEDSH-DYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWIT-------GWGAQREG 713

  Fly   292 GPTSTSLQKINLNVVTNQDCQTEYNNVATIYTGQMCTYDYSGTGRDSCQFDSGGPVILRK--SRQ 354
            ||.|::|||:::.::....|...|....   |.:|....|....:|:||.|||||::.::  .|.
  Rat   714 GPGSSTLQKVDVQLIPQDLCNEAYRYQV---TPRMLCAGYRKGKKDACQGDSGGPLVCKEPSGRW 775

  Fly   355 FLVGIISYGKSCAESQYPMGVNTRITSYISWIRQ 388
            ||.|::|:|..|....: .||.||:|..::||:|
  Rat   776 FLAGLVSWGLGCGRPNF-FGVYTRVTRVVNWIQQ 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30371	NP_610370.1	CUB	24..>67	CDD:294042	14/97 (14%)
		Tryp_SPc	149..386	CDD:214473	67/244 (27%)
		Tryp_SPc	150..389	CDD:238113	69/247 (28%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060	5/29 (17%)
		LDLa	495..525	CDD:238060	7/29 (24%)
		Ldl_recept_a	529..566	CDD:278486	4/36 (11%)
		Tryp_SPc	576..806	CDD:214473	67/244 (27%)
		Tryp_SPc	577..809	CDD:238113	69/247 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I4333
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960