DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30371 and C1r

DIOPT Version :9

Sequence 1:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001128027.1	Gene:	C1r / 312705	RGDID:	1309091	Length:	707	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	129/542 - (23%)
Similarity:	193/542 - (35%)	Gaps:	198/542 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 CDNTFNLSPGTTYVESPYYPNNYPGGTSCRY------------KFTAP--LDYYIQVQC---SLG 71
            |.:.....| :.|:.|..||..||....|.|            ||..|  :|.:.||.|   .|.
  Rat   193 CSSGLYTEP-SGYISSLEYPKPYPPDLRCNYSIRVERGLTVHLKFLDPFEIDDHQQVHCPYDQLQ 256

  Fly    72 IPKGNGQ-----CTTDN--------------FWLDTEGD-------------------------- 91
            | ..||:     |.|..              |:.|..||
  Rat   257 I-YANGKNLGEFCGTQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKALDEFTI 320

  Fly    92 ----------------------LLMRGAENF------------------------CGS-GTLSRE 109
                                  .||.|::..                        ||. .:||..
  Rat   321 IQDPQPQYQFRDYFIVTCKQGYQLMEGSQALLSFTAVCQHDGTWHRAMPRCKIKDCGQPRSLSNG 385

  Fly   110 SLFTELVFAYISTG---------------------TKGGS-------FKCTLTTVKQN------- 139
            .      |.|::|.                     |:.||       :.||...:.:|
  Rat   386 D------FRYLTTRGVNTYEARIQYYCHDPYYKMMTRAGSSESVRGIYTCTPQGIWKNEEEGEKM 444

  Fly   140 --C--NCG-----WSATTRIANGQQAAANEFPSMAALKDVTKNQASFCGGTIVAHRYILTAAHCI 195
              |  .||     .:...||..||:|....||..|     ..|.....||.::..|:||||||.|
  Rat   445 PRCLPVCGKPVNPVTQKQRIIGGQKANPGNFPWQA-----FTNIHGRGGGALLGDRWILTAAHTI 504

  Fly   196 Y-QVSRATNIVAIVGTNDLG--NPSSSRYYQQYNIQQMIPHEQYVSDPDVNN---DIAVLITASN 254
            | :.....|.|.:.....||  |....:....:.::::|.|..|..| :.||   |||:|...::
  Rat   505 YPKEHNKENNVNVSKDVFLGHTNVEEIKKLGHHPVRRVIIHPDYRQD-EPNNFEGDIALLELENS 568

  Fly   255 IQWSRGVGPICLPPVGTSTPFTYDLVDVIGYGTVFFAGPT----STSLQKINLNVVTNQDCQ--- 312
            :.....:.|||||...|    .|| .|::||.:.|  |.|    :.:|:.:.|.:...:.||
  Rat   569 VTLGPNLLPICLPDNET----FYD-KDLMGYVSGF--GITEDKIAFNLRFVRLPIADREACQRWL 626

  Fly   313 -TEYNNVATIYTGQM-CTYDYSGTGRDSCQFDSGGPVILR-KSRQFLV--GIISYGKSCAESQYP 372
             |:.:|  .:::..| |:.|.: ...|:||.||||...:| :||...|  ||:|:|..|.|.
  Rat   627 RTKNSN--DVFSQNMFCSGDPT-LKHDACQGDSGGVFAVRDRSRDIWVATGIVSWGIGCGEG--- 685

  Fly   373 MGVNTRITSYISWIRQKIGNSN 394
            .|..|::.:|:.||:::||:.|
  Rat   686 YGFYTKLLNYVDWIKKEIGDEN 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30371	NP_610370.1	CUB	24..>67	CDD:294042	15/56 (27%)
		Tryp_SPc	149..386	CDD:214473	78/254 (31%)
		Tryp_SPc	150..389	CDD:238113	79/256 (31%)
C1r	NP_001128027.1	CUB	27..138	CDD:214483
		FXa_inhibition	161..189	CDD:291342
		CUB	195..302	CDD:278839	26/108 (24%)
		Sushi	309..371	CDD:278512	3/61 (5%)
		Sushi	376..447	CDD:278512	13/76 (17%)
		Tryp_SPc	463..699	CDD:214473	78/254 (31%)
		Tryp_SPc	464..701	CDD:238113	79/255 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000