DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30371 and Corin

DIOPT Version :9

Sequence 1:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_872279.2	Gene:	Corin / 289596	RGDID:	727887	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	95/398 - (23%)
Similarity:	161/398 - (40%)	Gaps:	95/398 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QVQCSLGIPKGNGQCTTDNFWLDTEGD-----------------------LLMRGA--ENFCGSG 104
            :::|:      |.:|...:.|.|...|                       .:.|.|  .:.|..|
  Rat   725 ELECA------NHECVPRDLWCDGWTDCSDSSDEWGCVTLSKNGNSSSFLTVHRSARDHHVCADG 783

  Fly   105 ---TLSR---------ESLFTELVFAYISTGTKG------------------------------G 127
               |||:         |...||||     .|.:|                              |
  Rat   784 WQETLSQLACRQMGLGEPSVTELV-----QGQEGQQWLRLHSSWENLNGSTLQELLVHRRSCPSG 843

  Fly   128 SFKCTLTTVKQNCNCGWSA--TTRIANGQQAAANEFPSMAALKDVTKNQASFCGGTIVAHRYILT 190
            | :.:|...||:|....:|  ..||..|:.:....:|...:|:  ::.....||..::|.:::||
  Rat   844 S-EISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQ--SEPSGHICGCVLIAKKWVLT 905

  Fly   191 AAHCIYQVSRATNIVAIVGTNDLGNPSSSRYYQQYNIQQMIPHEQYVSDPDVNNDIAVLITASNI 255
            .|||......|.....:.|.|:|.:||.  :.|...::.::.|.:| |...|:.||:|:..:.:|
  Rat   906 VAHCFEGREDADVWKVVFGINNLDHPSG--FMQTRFVKTILLHPRY-SRAVVDYDISVVELSDDI 967

  Fly   256 QWSRGVGPICLP-PVGTSTPFTYDLVDVIGYGTVFFAGPTSTSLQKINLNVVTNQDCQTEYNNVA 319
            ..:..|.|:||| |.....|.||  ..:.|:|  .........||:..:.::..:.||: |.::.
  Rat   968 NETSYVRPVCLPSPREFLEPDTY--CYITGWG--HMGNKMPFKLQEGEVRIIPLEQCQS-YFDMK 1027

  Fly   320 TIYTGQMCTYDYSGTGRDSCQFDSGGPVILRK--SRQFLVGIISYGKSCAESQYPMGVNTRITSY 382
            ||....:|....||| .|||..|||||::..:  .:..|.|:.|:|..|.......||.:.::.:
  Rat  1028 TITNRMICAGYESGT-VDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNVSYF 1091

  Fly   383 ISWIRQKI 390
            :.||.::|
  Rat  1092 VDWIERQI 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30371	NP_610370.1	CUB	24..>67	CDD:294042	0/1 (0%)
		Tryp_SPc	149..386	CDD:214473	65/239 (27%)
		Tryp_SPc	150..389	CDD:238113	66/241 (27%)
Corin	NP_872279.2	DDNN motif	93..96
		CRD_corin_1	200..329	CDD:143554
		LDLa	335..370	CDD:238060
		LDLa	372..406	CDD:238060
		Ldl_recept_a	413..443	CDD:395011
		LDLa	453..480	CDD:238060
		CRD_corin_2	521..641	CDD:143579
		Ldl_recept_a	646..680	CDD:395011
		LDLa	<693..718	CDD:238060
		LDLa	721..755	CDD:238060	6/35 (17%)
		SRCR_2	779..859	CDD:413346	18/85 (21%)
		Tryp_SPc	867..1098	CDD:238113	66/241 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910