DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30371 and Tmprss7

DIOPT Version :9

Sequence 1:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001099352.2	Gene:	Tmprss7 / 288118	RGDID:	1304655	Length:	829	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	115/520 - (22%)
Similarity:	189/520 - (36%)	Gaps:	179/520 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VLAYFE-----GCDNTFNLSPGTTY---VESPYYPNNYPGGTSCRYKFTAPLDYYIQVQCSLGIP 73
            :.||||     .|:||..:....::   :.|||||:.||....|.:.|...|.       :|||
  Rat   339 IRAYFEVIPEQKCENTILVKEINSFEGKISSPYYPSYYPPKCKCNWTFQTSLS-------TLGI- 395

  Fly    74 KGNGQCTTDNFWLDTEGDLLMRGAEN---------FCG----------------------SGTLS 107
                .....|:.:..:.   |:|.|:         :||                      |..||
  Rat   396 ----ALKFHNYSITKKS---MKGCEHGWWEINEHMYCGSYMDHETIFRVPSPLVHIQLQCSSRLS 453

  Fly   108 RESLFTELVFAYISTGTKGGSFKCT-------------------------LTTVKQNCN------ 141
            .:.|..|.....||.....|||:|:                         ..|.|..||
  Rat   454 DKPLLVEYGSYNISQPCPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVTAKPACNTSIFRQ 518

  Fly   142 -------------------------------------------------------------CGWS 145
                                                                         ||.|
  Rat   519 HGPLVCDGFQDCEDGQDEQNCTRSIPCTNRTFKCGNDICFRKQNAQCDGIVDCPDRSDEEGCGCS 583

  Fly   146 ATT----RIANGQQAAANEFPSMAALKDVTKNQASFCGGTIVAHRYILTAAHCIY--QVSRATNI 204
            .::    |:..|..:....:|...:|..|   .::.||.::::..::|:||||.:  ::|..|..
  Rat   584 RSSPFLHRVVGGSDSQEGTWPWQVSLHFV---GSAHCGASVISREWLLSAAHCFHGNRLSDPTPW 645

  Fly   205 VAIVGTNDLGNPSSSRYYQQYNIQQMIPHEQYVSDPDVNNDIAVLITASNIQWSRG----VGPIC 265
            .|.:|....||   :::...  :::::.||.|.|. ..:.|||:|  ..:|.|...    :.|||
  Rat   646 TAHLGMYVQGN---AKFVSP--VRRIVVHEYYNSQ-TFDYDIALL--QLSIAWPETLRQLIQPIC 702

  Fly   266 LPPVGTSTPFTYDLVDVIGYGTVFFA-GPTSTSLQKINLNVVTNQDCQTEYNNVATIYTGQM-CT 328
            :||||.... :.:...|.|:|....| ...|..||:..:.::....|.:.|.    |.|.:| |.
  Rat   703 IPPVGQRVR-SGEKCWVTGWGRRHEADSKGSPILQQAEVELIDQTVCVSTYG----IITSRMLCA 762

  Fly   329 YDYSGTGRDSCQFDSGGPVILRK---SRQFLVGIISYGKSCAESQYPMGVNTRITSYISWIRQKI 390
            ...||.. |:|:.|||||:..|:   .:..|.||:|:|..|....:| ||.||:::::.||.:.:
  Rat   763 GVMSGKS-DACKGDSGGPLSCRRKSDGKWILTGIVSWGYGCGRPNFP-GVYTRVSNFVPWIHKYV 825

Fly 391 390
Rat 826 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30371	NP_610370.1	CUB	24..>67	CDD:294042	13/45 (29%)
		Tryp_SPc	149..386	CDD:214473	69/247 (28%)
		Tryp_SPc	150..389	CDD:238113	70/249 (28%)
Tmprss7	NP_001099352.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
		SEA	94..190	CDD:279699
		CUB	<257..345	CDD:238001	3/5 (60%)
		LDLa	470..504	CDD:238060	4/33 (12%)
		LDLa	545..580	CDD:238060	0/34 (0%)
		Tryp_SPc	591..821	CDD:214473	69/247 (28%)
		Tryp_SPc	592..823	CDD:238113	70/248 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I4333
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050