DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30371 and Masp2

DIOPT Version :9

Sequence 1:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001003893.1	Gene:	Masp2 / 17175	MGIID:	1330832	Length:	685	Species:	Mus musculus

Alignment Length:	378	Identity:	97/378 - (25%)
Similarity:	155/378 - (41%)	Gaps:	90/378 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PNNYPGGTSCRYKFTAPLDY-----------YIQVQC--SLGIPKGNGQ--CTTDNFWLDTEGDL 92
            |::.|.|         .:||           .||..|  :......||:  |..|.||..::|:.
Mouse   369 PDDLPNG---------HVDYITGPEVTTYKAVIQYSCEETFYTMSSNGKYVCEADGFWTSSKGEK 424

  Fly    93 LMRGAENFCGSGTLSRESLFTELVFAYISTGTKGGSFKCTLTTVKQNCNCGWSATTRIANGQQAA 157
            |....|..||                 :||.|.||                     ||..||.|.
Mouse   425 LPPVCEPVCG-----------------LSTHTIGG---------------------RIVGGQPAK 451

  Fly   158 ANEFPSMAALKDVTKNQASFCGGTIVAHRYILTAAHCIYQVSRATNIVAI-VGTNDLGNPSSSRY 221
            ..:||....|    ..|.:...|.::...::|||||.:|:...|.:.:.| :|.....:|    :
Mouse   452 PGDFPWQVLL----LGQTTAAAGALIHDNWVLTAAHAVYEKRMAASSLNIRMGILKRLSP----H 508

  Fly   222 YQQYNIQQMIPHEQYVSDPDVNNDIAVLITASNIQWSRGVGPICLPPVGTSTPFTYDLV-DVIGY 285
            |.|...:::..||.|......:||||::...:.:..:..:.|:|||....::....|.. .|.|:
Mouse   509 YTQAWPEEIFIHEGYTHGAGFDNDIALIKLKNKVTINGSIMPVCLPRKEAASLMRTDFTGTVAGW 573

  Fly   286 GTVFFAGPTSTSLQKINLNVVTNQDCQTEYNNVATIYTG------QMCTYDYSGTGRDSCQFDSG 344
            | :...|..:.:|..:::.:..:|.|...|..   :|.|      .:|....:| |:|||:.|||
Mouse   574 G-LTQKGLLARNLMFVDIPIADHQKCTAVYEK---LYPGVRVSANMLCAGLETG-GKDSCRGDSG 633

  Fly   345 GPVIL---RKSRQFLVGIISYGK-SC-AESQYPMGVNTRITSYISWIRQKIGN 392
            |.::.   ...|.|:.||:|:|. :| |..||  ||.|::.:||.||...|.|
Mouse   634 GALVFLDNETQRWFVGGIVSWGSINCGAADQY--GVYTKVINYIPWIENIISN 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30371	NP_610370.1	CUB	24..>67	CDD:294042	7/34 (21%)
		Tryp_SPc	149..386	CDD:214473	69/249 (28%)
		Tryp_SPc	150..389	CDD:238113	70/251 (28%)
Masp2	NP_001003893.1	CUB	19..136	CDD:238001
		FXa_inhibition	152..180	CDD:291342
		CUB	184..293	CDD:278839
		Sushi	300..361	CDD:278512
		Sushi	366..429	CDD:278512	16/68 (24%)
		Tryp_SPc	443..678	CDD:214473	69/249 (28%)
		Tryp_SPc	444..681	CDD:238113	70/251 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910