DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30371 and MASP2

DIOPT Version :9

Sequence 1:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens

Alignment Length:	417	Identity:	112/417 - (26%)
Similarity:	175/417 - (41%)	Gaps:	97/417 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HLPLISLLLFAPTVLAYFEGC-DNTFNLSPGTTYVE-SPYYPNNYPGGTSCRYKF-TAP-LDYY- 63
            ||||.|.     |.:...:|. |...   |..:.|: .|  |::.|.|   |.:: |.| :..|
Human   338 HLPLKSF-----TAVCQKDGSWDRPM---PACSIVDCGP--PDDLPSG---RVEYITGPGVTTYK 389

  Fly    64 --IQVQC-----SLGIPKGNGQCTTDNFWLDTEGDLLMRGAENFCGSGTLSRESLFTELVFAYIS 121
              ||..|     ::.:..|...|..|.||..::|:..:...|..||                 :|
Human   390 AVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCG-----------------LS 437

  Fly   122 TGTKGGSFKCTLTTVKQNCNCGWSATTRIANGQQAAANEFPSMAALKDVTKNQASFCGGTIVA-- 184
            ..|.||                     ||..||:|...:||.          |....|||..|
Human   438 ARTTGG---------------------RIYGGQKAKPGDFPW----------QVLILGGTTAAGA 471

  Fly   185 ---HRYILTAAHCIYQVSRATNIVAI-VGTNDLGNPSSSRYYQQYNIQQMIPHEQYVSDPDVNND 245
               ..::|||||.:|:.....:.:.| :||....:|    :|.|...:.:..||.|..|...:||
Human   472 LLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSP----HYTQAWSEAVFIHEGYTHDAGFDND 532

  Fly   246 IAVLITASNIQWSRGVGPICLP-PVGTSTPFTYDLVDVIGYGTVFFAGPTSTSLQKINLNVVTNQ 309
            ||::...:.:..:..:.||||| ....|...|.|:....|:| :...|..:.:|..:::.:|.:|
Human   533 IALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWG-LTQRGFLARNLMYVDIPIVDHQ 596

  Fly   310 DCQTEYNNV----ATIYTGQMCTYDYSGTGRDSCQFDSGGPVILRKS---RQFLVGIISYGK-SC 366
            .|...|...    .::....:|....|| |:|||:.||||.::...|   |.|:.||:|:|. :|
Human   597 KCTAAYEKPPYPRGSVTANMLCAGLESG-GKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC 660

  Fly   367 AES-QYPMGVNTRITSYISWIRQKIGN 392
            .|: ||  ||.|::.:||.||...|.:
Human   661 GEAGQY--GVYTKVINYIPWIENIISD 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30371	NP_610370.1	CUB	24..>67	CDD:294042	13/49 (27%)
		Tryp_SPc	149..386	CDD:214473	75/252 (30%)
		Tryp_SPc	150..389	CDD:238113	76/254 (30%)
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839
		CCP	300..361	CDD:214478	9/30 (30%)
		Sushi	366..430	CDD:278512	17/68 (25%)
		Tryp_SPc	444..679	CDD:214473	75/252 (30%)
		Tryp_SPc	445..682	CDD:238113	76/254 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910