Protein Alignment CG14760 and C1R

DIOPT Version :9

• Sequence 1: NP_610366.1
• Gene: CG14760 / 35802
• FlyBaseID: FBgn0033277
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001341275.1
• Gene: C1R / 715
• HGNCID: 1246
• Length: 719
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 124/575 - (21%)
• Similarity: 211/575 - (36%)
• Gaps: 138/575 - (24%)

  Fly    22 QCNHQVKLQ-SGQKLLINSPYYPALYPVGTSCRYAVEAPKDHVLQFKCELQLRTLSTD----LKC 81
            :|:.::..: ||   .|:|..||..||....|.|::...:...|..|.   |.....|    :.|
Human   206 ECSSELYTEASG---YISSLEYPRSYPPDLRCNYSIRVERGLTLHLKF---LEPFDIDDHQQVHC 264

  Fly    82 RTEVFHFNSEGDEVLTSSEYFCGSGKFERKSFLNRAVISYISSGHSEPPSAVKLKDKLHAVPTTS 146
            ..:.....:.|..:    ..|||..:.......:.||.....:..|......||:       .|:
Human   265 PYDQLQIYANGKNI----GEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLR-------YTT 318

  Fly   147 TTTEAPQAVSIEEQDAEEEQEEEEEPEEADEDL-------------SDEVLH----VLQDVGVSD 194
            ...:.||..:::|....:..    :|:....|.             .::|||    |.||.|...
Human   319 EIIKCPQPKTLDEFTIIQNL----QPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWH 379

  Fly   195 ALAYVASLLYDVEESR-------KSSTTIYLD---------------KLPIRSSSKTSAKRARIV 237
            . |.....:.|..:.|       :.:||:.::               |:..|:.|:.|.:
Human   380 R-AMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQ----- 438

  Fly   238 SSYPTAAPSPGHGGGRFSCLVEAFQ---------PTCSCGWSRIPRIASPTN-----------EE 282
                          |.::|..:...         |.|      :|....|.|           ::
Human   439 --------------GVYTCTAQGIWKNEQKGEKIPRC------LPVCGKPVNPVEQRQRIIGGQK 483

  Fly   283 AVLHEFPPMAGVLTKKHGKVFCGAAIIHHRYLLSAAHCFLGP---ETNSAAKLRVVVGEHDLASS 344
            |.:..||..  |.|..||:  .|.|::..|::|:|||. |.|   |..|.|.|.|.:|..::.
Human   484 AKMGNFPWQ--VFTNIHGR--GGGALLGDRWILTAAHT-LYPKEHEAQSNASLDVFLGHTNVE-- 541

  Fly   345 FETFATQRYDLDALILHEDFSQ-ASGQPKNDIAMLKTRMAIVWSQHVGPACLPLQPGEDGQKLPL 408
             |......:.:..:.:|.|:.| .|...:.|||:|:...::....::.|.|||  ..:....|.|
Human   542 -ELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLP--DNDTFYDLGL 603

  Fly   409 AGHQVVAAGWGTTSYGGPQTHRLLKATLDVIDGRRCRQALSSAGGL---PPHTFCTYTPG--RDT 468
            .|:   .:|:|...  ....|.|....|.|.:.:.|...|.....:   ..:.||...|.  :|.
Human   604 MGY---VSGFGVME--EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDA 663

  Fly   469 CQYDSGG--ALYERINGRLMAVGIVSFGQACAAQQPSVNTRVASFIKWIRTKSPE 521
            ||.||||  |:.:....|.:|.||||:|..| ::.....|:|.:::.||:.:..|
Human   664 CQGDSGGVFAVRDPNTDRWVATGIVSWGIGC-SRGYGFYTKVLNYVDWIKKEMEE 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14760	NP_610366.1	CUB	37..126	CDD:294042	19/92 (21%)
		Tryp_SPc	281..516	CDD:238113	68/245 (28%)
		Tryp_SPc	281..515	CDD:214473	67/244 (27%)
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839	25/125 (20%)
		Sushi	323..385	CDD:306569	13/66 (20%)
		Sushi	390..461	CDD:306569	10/89 (11%)
		Tryp_SPc	477..711	CDD:214473	67/249 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910