Protein Alignment CG14760 and MASP1

DIOPT Version :9

• Sequence 1: NP_610366.1
• Gene: CG14760 / 35802
• FlyBaseID: FBgn0033277
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: XP_011511291.1
• Gene: MASP1 / 5648
• HGNCID: 6901
• Length: 735
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 131/556 - (23%)
• Similarity: 223/556 - (40%)
• Gaps: 116/556 - (20%)

  Fly    36 LINSPYYPALYPVGTSCRYAVEAPKDHVLQFKCELQLRTLSTDLKCRTEV-----FHFNSEGDEV 95
            :|.||.:|..||..:.|.|.:|..:.    |...||...: .|::...||     :.....|.:|
Human   203 VITSPDFPNPYPKSSECLYTIELEEG----FMVNLQFEDI-FDIEDHPEVPCPYDYIKIKVGPKV 262

  Fly    96 LTSSEYFCGSGKFERKSFLNRAVISYISSGHSEPPSAVKLKDKLHAVPTTSTTTEAPQAVSIEEQ 160
            |..   |||....|..|..:.:|:....|.:|......:|..:       :...|.|
Human   263 LGP---FCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR-------AAGNECP-------- 309

  Fly   161 DAEEEQEEEEEPEEADEDLSDEVL-------HVLQDVGVSDALAYVASLLYDVEESRKSSTTIYL 218
            :.:.....:.||.:|.....|:||       .||:|....|  .:....|.|...|.|..|...:
Human   310 ELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMD--TFQIECLKDGTWSNKIPTCKIV 372

  Fly   219 D-KLP-------IRSSSKTSAKRARIVSSYPTAAP---SPGHGGGRFSCLVEAF---------QP 263
            | :.|       |..|::.:....:....|....|   ...:..|.::|..:..         .|
Human   373 DCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSLP 437

  Fly   264 TC--SCGW------SRIPRIASPTNEEAVLHEFPPMAGVLTKKHGKV-----FCGAAIIHHRYLL 315
            ||  .||.      |.:.||....|.|..|  ||..|.::.:...:|     |...|::...::|
Human   438 TCLPECGQPSRSLPSLVKRIIGGRNAEPGL--FPWQALIVVEDTSRVPNDKWFGSGALLSASWIL 500

  Fly   316 SAAHCFLGPETN------SAAKLRVVVGEHDL---ASSFETFATQRYDLDALILHEDFSQASGQP 371
            :|||.......:      |...:.|.:|.||:   :.:..:.|.:      ::||.||:..:  .
Human   501 TAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAAR------VVLHPDFNIQN--Y 557

  Fly   372 KNDIAMLKTRMAIVWSQHVGPACLP-LQPGEDGQKLPLAGHQVVAAGWGTTS---------YGGP 426
            .:|||:::.:..:....||.|.||| |:|  :|....:.|   :.||||.::         ..|.
Human   558 NHDIALVQLQEPVPLGPHVMPVCLPRLEP--EGPAPHMLG---LVAGWGISNPNVTVDEIISSGT 617

  Fly   427 QT--HRLLKATLDVIDGRRCRQALSSAGG---LPPHTFCT--YTPGRDTCQYDSGGA--LYERIN 482
            :|  ..|....|.|:....|:.:..|..|   :..:.||.  |..|:|||..|||||  :::.::
Human   618 RTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLS 682

  Fly   483 GRLMAVGIVSFG--QACAAQQP-SVNTRVASFIKWI 515
            .|.:..|:||:|  :.|.::|. .|.|:|::::.|:
Human   683 QRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14760	NP_610366.1	CUB	37..126	CDD:294042	25/93 (27%)
		Tryp_SPc	281..516	CDD:238113	70/271 (26%)
		Tryp_SPc	281..515	CDD:214473	69/269 (26%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839	27/105 (26%)
		Sushi	308..369	CDD:278512	15/70 (21%)
		CCP	374..439	CDD:153056	8/64 (13%)
		Tryp_SPc	456..718	CDD:214473	72/276 (26%)
		Tryp_SPc	457..718	CDD:238113	71/275 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910