DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14760 and C1rl

DIOPT Version :9

Sequence 1:	NP_610366.1	Gene:	CG14760 / 35802	FlyBaseID:	FBgn0033277	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001002804.2	Gene:	C1rl / 408246	RGDID:	1302936	Length:	488	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	118/545 - (21%)
Similarity:	186/545 - (34%)	Gaps:	129/545 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WLLFLPLLKASSTNA---IFEQCNHQVKLQSGQKLLINSPYYPALYPVGTSCRYAVEAPKDHVLQ 65
            |||...:|....|.|   :.:|...|          :.||.||..|..|......:|||:.
  Rat    29 WLLLWGILHTCPTQASVLLAQQFPQQ----------LTSPGYPEPYIKGQESHADIEAPEG---- 79

  Fly    66 FKCELQLRTLSTDLKCRTEVFHFNSEGDEVL-----TSSEYFCGSGKFERKSFLNRAVISYISSG 125
                ..:|.:..|.......   ..|||.|.     |.:...||.......|..|:  :.::|||
  Rat    80 ----FAVRLIFQDFDLEPSP---GCEGDSVTISTRGTDATRLCGQQGSSLGSPPNQ--MEFVSSG 135

  Fly   126 HSEPPSAVKLKDKLHAVPTTSTTTEAP-----QAVSIEEQ--DAEEEQEEEEEPEEADEDLSDEV 183
            .|     ::|..:.|:.....|.....     ||:::.:.  |||........|.|...
  Rat   136 RS-----LRLTFRAHSSKNKVTHLHKGFLALYQAIAVSQPNGDAEAFTTPGANPPEIQN------ 189

  Fly   184 LHVLQDVGVSDALAYVASLLYDVEESRKSSTTIYLDKLPIRSSSKTSAKRARIVSSYPTAAPSPG 248
                          :.....|..|::...|.          .||:....|.| ....|...|
  Rat   190 --------------HCPGPYYKEEQTGTLSC----------PSSRKWKDRQR-GEEVPECVP--- 226

  Fly   249 HGGGRFSCLVEAFQPTCSCGWSRIPRIASPT---NEEAVLHEFPPMAGVLTKKHGKVFCGAAIIH 310
                             .||...:|...:|.   :..|....||..|  .|..:|:  .|.|::.
  Rat   227 -----------------VCGRPVVPIAENPNTFGSSRAKPGNFPWQA--FTSIYGR--GGGALLG 270

  Fly   311 HRYLLSAAHCFLGPETNSAAK---LRVVVGEHDLASSFETFATQRYDLDALILHEDFSQ-ASGQP 371
            .|::|:|||.....::....|   :.|.:|..|:.   |......:.:..:::|.|:.| .|...
  Rat   271 DRWILTAAHTIFPKDSIYLRKNKTVNVFLGHTDVD---ELLKLGNHPVRRVVVHPDYRQEESHNF 332

  Fly   372 KNDIAMLKTRMAIVWSQHVGPACLPLQPGEDGQKLPLAGHQVVAAGWGTTSYGGPQTHRLLKATL 436
            ..|||:|:....:.....:.|.|||     |.:.|..:|.....:|:|...  |..|.:|..:.|
  Rat   333 DGDIALLELEHRVPLGPSLLPVCLP-----DNETLYHSGLWGYISGFGVEM--GWLTTKLKYSKL 390

  Fly   437 DVIDGRRCRQAL---SSAGGLPPHTFCTYTPGRD-----TCQYDSGG--ALYERINGRLMAVGIV 491
            .|.....|...|   ........:.||.   |.:     .||.|||.  .:::....|.:|.|||
  Rat   391 PVAPREACEAWLRQRQRTEVFSDNMFCV---GEEMQVNSVCQGDSGSVYVVWDDRALRWVATGIV 452

  Fly   492 SFGQACAAQQPSVNTRVASFIKWIR 516
            |:|..| .:.....|:|.|::.||:
  Rat   453 SWGVGC-GKGYGFYTKVLSYVDWIK 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14760	NP_610366.1	CUB	37..126	CDD:294042	22/93 (24%)
		Tryp_SPc	281..516	CDD:238113	62/248 (25%)
		Tryp_SPc	281..515	CDD:214473	61/247 (25%)
C1rl	NP_001002804.2	CUB	55..164	CDD:238001	27/126 (21%)
C1rl	NP_001002804.2	Tryp_SPc	243..476	CDD:238113	62/250 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000