Protein Alignment CG14760 and TMPRSS6

DIOPT Version :9

• Sequence 1: NP_610366.1
• Gene: CG14760 / 35802
• FlyBaseID: FBgn0033277
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001275929.1
• Gene: TMPRSS6 / 164656
• HGNCID: 16517
• Length: 824
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 125/566 - (22%)
• Similarity: 205/566 - (36%)
• Gaps: 135/566 - (23%)

  Fly    19 IFEQCNHQVKLQSGQKL----LINSPYYPALYPVGTSCRYAVEAPK-DHVLQFKCE-LQLRTLST 77
            :|:.|  :|.|....:|    ::::||:|:.|...|.|.:.:..|. |:.|....: ..||....
Human   322 VFQAC--EVNLTLDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKY 384

  Fly    78 DLKCRTEVFHFNSEGDEVLTSSEYFCGSGKFERKSFLNRAVISYISSGHSEPPSAVKLKDKLHAV 142
            ||.|        ::|...: .:...||.          |.:..|              .:::..|
Human   385 DLPC--------TQGQWTI-QNRRLCGL----------RILQPY--------------AERIPVV 416

  Fly   143 PTTSTTTEAPQAVSIEEQDAEEEQ--EEEEEPEEADEDLSDEVLHVLQDVGVSD---ALAYVASL 202
            .|...|......:|:.........  ..:.:|...:...|...|.|....||.|   .|.....:
Human   417 ATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDCPNGLDERNCV 481

  Fly   203 LYDVEESRKSSTTIYLDKL----P--IRSSSKTSAKRARIVSSYP--------TAAPSPGHGGGR 253
            .....:.::.||.|.|.|:    |  :..|.:...:......::.        ...|:| ...||
Human   482 CRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNP-QCDGR 545

  Fly   254 FSCLVEAFQPTCSCGW----SRIPRIASPTNEEAVLHEFPPMAGVLTKKHGKVFCGAAIIHHRYL 314
            ..|...:.:..|.||.    |||  :....:.|.   |:|..|.:..:  |:..||.|:|..|::
Human   546 PDCRDGSDEEHCDCGLQGPSSRI--VGGAVSSEG---EWPWQASLQVR--GRHICGGALIADRWV 603

  Fly   315 LSAAHCFLGPETNSAAKLRVVVGEHDLASSFETFATQR------YDLDALILHEDFSQASGQPKN 373
            ::|||||......|.....|.:|        :.:...|      :.:..|:||....:.|..  .
Human   604 ITAAHCFQEDSMASTVLWTVFLG--------KVWQNSRWPGEVSFKVSRLLLHPYHEEDSHD--Y 658

  Fly   374 DIAMLKTRMAIVWSQHVGPACLP-----LQPGEDGQKLPLAGHQVVAAGWGTTSYGG-------- 425
            |:|:|:....:|.|..|.|.|||     .:||.         |..: .|||....|.
Human   659 DVALLQLDHPVVRSAAVRPVCLPARSHFFEPGL---------HCWI-TGWGALREGALRADAVAL 713

  Fly   426 --------------PQTHRLLKATLDVIDGRRCRQALSSAGGLPPHTFCT-YTPG-RDTCQYDSG 474
                          |.::.|.|..:.:|....|.:.....  :.|...|. |..| :|.||.|||
Human   714 FYGWRNQGSETCCCPISNALQKVDVQLIPQDLCSEVYRYQ--VTPRMLCAGYRKGKKDACQGDSG 776

  Fly   475 GALY-ERINGRLMAVGIVSFGQACAAQQPS---VNTRVASFIKWIR 516
            |.|. :.::||....|:||:|..|.  :|:   |.||:...|.||:
Human   777 GPLVCKALSGRWFLAGLVSWGLGCG--RPNYFGVYTRITGVISWIQ 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14760	NP_610366.1	CUB	37..126	CDD:294042	19/90 (21%)
		Tryp_SPc	281..516	CDD:238113	70/273 (26%)
		Tryp_SPc	281..515	CDD:214473	69/272 (25%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001	27/148 (18%)
		LDLa	450..480	CDD:238060	7/29 (24%)
		LDLa	486..516	CDD:238060	7/29 (24%)
		Ldl_recept_a	520..557	CDD:278486	5/37 (14%)
		Tryp_SPc	568..822	CDD:238113	72/284 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4403
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960