Protein Alignment CG14760 and MASP2

DIOPT Version :9

• Sequence 1: NP_610366.1
• Gene: CG14760 / 35802
• FlyBaseID: FBgn0033277
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_006601.2
• Gene: MASP2 / 10747
• HGNCID: 6902
• Length: 686
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 134/578 - (23%)
• Similarity: 216/578 - (37%)
• Gaps: 167/578 - (28%)

  Fly    23 CNHQVKLQ-SGQKLLINSPYYPALYPVGTSCRYAVEAPK------DHVLQFKCELQLRTLSTDLK 80
            |:.||..| ||:   ::||.||..||..:||.|::...:      |.|..|..|....||
Human   184 CSGQVFTQRSGE---LSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL----- 240

  Fly    81 CRTEVFHFNSEGDEVLTSSEYFCGS---GKFERKSFLNRAVISYIS------------------- 123
            |..:.....::.:|    ...|||.   .:.|.||  |...|::::
Human   241 CPYDFLKIQTDREE----HGPFCGKTLPHRIETKS--NTVTITFVTDESGDHTGWKIHYTSTAQP 299

  Fly   124 --------SGHSEPPSA-VKLKDKLHA------------VPTTSTTTEAPQAVSIEEQDAEEEQE 167
                    :||..|..| ..|||....            :|..|.|       ::.::|...::
Human   300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFT-------AVCQKDGSWDR- 356

  Fly   168 EEEEPEEA--------DEDLSDEVLHVLQDVGVSDALAYVASLLYDVEESRKSSTTIYLDKLPIR 224
                |..|        .:||....:..:...||:   .|.|.:.|..||      |.|..|:
Human   357 ----PMPACSIVDCGPPDDLPSGRVEYITGPGVT---TYKAVIQYSCEE------TFYTMKV--- 405

  Fly   225 SSSKTSAKRARIVSSYPTAAPSPGHGGGRFSCLVEAF---------QPTCS--CGWSRIPRIASP 278
                                     ..|::.|..:.|         .|.|.  ||.|     |..
Human   406 -------------------------NDGKYVCEADGFWTSSKGEKSLPVCEPVCGLS-----ART 440

  Fly   279 T------NEEAVLHEFPPMAGVLTKKHGKVFCGAAIIHHRYLLSAAHCFLGPETNSAAKLRVVVG 337
            |      .::|...:||....:|    |......|:::..::|:|||. :..:.:.|:.|.:.:|
Human   441 TGGRIYGGQKAKPGDFPWQVLIL----GGTTAAGALLYDNWVLTAAHA-VYEQKHDASALDIRMG 500

  Fly   338 EHDLASSFETFATQRYDLDALILHEDFSQASGQPKNDIAMLKTRMAIVWSQHVGPACLPLQPGED 402
            .....|...|.|..    :|:.:||.::..:|. .||||::|....:|.:.::.|.|||.:..|.
Human   501 TLKRLSPHYTQAWS----EAVFIHEGYTHDAGF-DNDIALIKLNNKVVINSNITPICLPRKEAES 560

  Fly   403 GQKLPLAGHQVVAAGWGTTSYGGPQTHRLLKATLDVIDGRRCRQALSS----AGGLPPHTFCT-- 461
            ..:....|   .|:|||.|..|. ....|:...:.::|.::|..|...    .|.:..:..|.
Human   561 FMRTDDIG---TASGWGLTQRGF-LARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGL 621

  Fly   462 YTPGRDTCQYDSGGAL--YERINGRLMAVGIVSFGQA-CA-AQQPSVNTRVASFIKWI 515
            .:.|:|:|:.||||||  .:....|....||||:|.. |. |.|..|.|:|.::|.||
Human   622 ESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWI 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14760	NP_610366.1	CUB	37..126	CDD:294042	25/124 (20%)
		Tryp_SPc	281..516	CDD:238113	68/245 (28%)
		Tryp_SPc	281..515	CDD:214473	66/243 (27%)
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839	31/122 (25%)
		CCP	300..361	CDD:214478	12/72 (17%)
		Sushi	366..430	CDD:278512	16/100 (16%)
		Tryp_SPc	444..679	CDD:214473	66/248 (27%)
		Tryp_SPc	445..682	CDD:238113	68/249 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000