DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and sept15

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_021326214.1	Gene:	sept15 / 792259	ZFINID:	ZDB-GENE-061103-265	Length:	468	Species:	Danio rerio

Alignment Length:	435	Identity:	275/435 - (63%)
Similarity:	340/435 - (78%)	Gaps:	22/435 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 QKPMEIAGYVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSL 178
            |....:.|||||||||||||||:|||||||||||||.|||||||||||:||:|:| ::.|||||.
Zfish    47 QNQRNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLY-SKDYPGPSQ 110

  Fly   179 RKKKTVAVEATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYR 243
            |.||||.||.:||::||.||.||||:||||||||||||||||.|::.|:|||:|::|.|||||.|
Zfish   111 RIKKTVQVEQSKVLIKEGGVQLTLTIVDTPGFGDAVDNSNCWQPVINYIDSKFEDFLNAESRVNR 175

  Fly   244 KTISDSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEI 308
            :.:.|:||||||||||||||||.||||..|:.|.||||::|:||||||:||:|..||||||:.||
Zfish   176 RQMPDNRVHCCLYFIAPSGHGLKPLDIEFMKRLHDKVNVIPLIAKADTLTPEECQLFKKQIMKEI 240

  Fly   309 AQHKIKIYDFPATLEDAAEEAKTTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVE----V 369
            .:||||||:||.|.:|  |::|..:.::.::|.||||:|.:||.:|:|||||:||||:.|    |
Zfish   241 QEHKIKIYEFPDTEDD--EDSKLIRKIKEKMPLAVVGSNVVIEVNGRKVRGRQYPWGVAEEGIVV 303

  Fly   370 ENLTHCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSELGL--VD---GKARLSNKNPLTQ 429
            ||..||||..||||:||||:||||||||||||||||.:||:.:..  ||   .|.:|: |:||.|
Zfish   304 ENGEHCDFTVLRNMLIRTHMQDLKDVTNNVHYENYRSKKLAAVTCNGVDATKNKGQLT-KSPLAQ 367

  Fly   430 MEEEKREHEQKMKKMEAEMEQVFDMKVKEKMQKLRDSELELARRHEERKKALELQIRELEEKRRE 494
            ||||:|||..||||||.||||||:||||||.|||:|||.||.||||:.||.||.|.:|||||||:
Zfish   368 MEEERREHVMKMKKMETEMEQVFEMKVKEKKQKLKDSEAELERRHEQMKKNLEAQYKELEEKRRQ 432

  Fly   495 FEREKKEWEDVNHVTLEELKRRSLGANSSTDNVDGKKEKKKKGLF 539
            ||.||..||....:    |:::.|.|:.:.:     |.|||..:|
Zfish   433 FEDEKANWEAQQRI----LEQQKLDASKTME-----KNKKKGKIF 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	250/369 (68%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	186/275 (68%)
sept15	XP_021326214.1	CDC_Septin	72..346	CDD:206649	186/276 (67%)
sept15	XP_021326214.1	V-ATPase_G_2	367..>466	CDD:330366	63/107 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592781
Domainoid	1	1.000	399	1.000	Domainoid score	I702
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1116
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm25008
orthoMCL	1	0.900	-	-		OOG6_104146
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940