DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and Septin6

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_017457646.1	Gene:	Septin6 / 691335	RGDID:	1585082	Length:	490	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	170/465 - (36%)
Similarity:	269/465 - (57%)	Gaps:	45/465 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 LQEKEHQQAQKPQKPPLPVRQKP----------MEIAGYVGFANLPNQVYRKAVKRGFEFTLMVV 148
            |.|...:| ::.|.|...|...|          :.:||:|||.:||:|:..|:|.:||.|.::.|
  Rat    41 LNETRWRQ-RRIQAPKRAVGHSPRGLWGEDCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFNILCV 104

  Fly   149 GASGLGKSTLINSMFLSDIYNAEQYPGPSLRKKKTVAVEATKVMLKENGVNLTLTVVDTPGFGDA 213
            |.:|||||||::::|     |.:....|:...:..|.:.::...|:|:.|.|.||:|.|.||||.
  Rat   105 GETGLGKSTLMDTLF-----NTKFEGEPTTHTQPGVQLRSSTYDLQESNVGLKLTIVSTVGFGDQ 164

  Fly   214 VDNSNCWVPILEYVDSKYEEYLTAESRVYR--KTISDSRVHCCLYFIAPSGHGLLPLDIACMQSL 276
            ::..:.:.||:|::|:::|.||..|.::.|  .:..|||:|.|||||||:||.|..||:..|:.|
  Rat   165 INKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHSYHDSRIHACLYFIAPTGHSLKSLDLVTMKKL 229

  Fly   277 SDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIYDFPATLEDAAEEAKTTQNLRSRVPF 341
            ..|||::|:|||:|.::..|:..||.:|.:|:..:.::||.||...|..||...|   :.:.:||
  Rat   230 DSKVNIIPIIAKSDAISKSELAKFKIKITSELVSNGVQIYQFPTDDESVAEINGT---MNAHLPF 291

  Fly   342 AVVGANTIIEQDGKKVRGRRYPWGLVEVENLTHCDFIALRNMVIRTHLQDLKDVTNNVHYENYRC 406
            ||||:...::...|.:|.|:||||.|:|||..||||:.||.|:||.:::||::.|:..|||.||.
  Rat   292 AVVGSTEEVKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIRINMEDLREQTHARHYELYRR 356

  Fly   407 RKLSELGLVDGKARLSNKNPLTQME--EEKR-EHEQKMKKMEAEMEQVFDMKVKEKMQKLRDSEL 468
            .||.|:|..|..   .:..|.:..|  |.|| |...:::|.|.||.|:|..:||||..:|:::|.
  Rat   357 CKLEEMGFKDTD---PDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKEAEK 418

  Fly   469 ELARR-------HEERKKALELQIRELEEKRREFEREKKEWEDVNHVTLEELKRRSLGANSSTDN 526
            ||..:       |:|.||.||.:.:.|:|:...|::.|        ...|.|:.:...|..|...
  Rat   419 ELHEKFDRLKKLHQEEKKKLEDKKKCLDEEMNAFKQRK--------AAAELLQSQGSQAGGSQTL 475

  Fly   527 VDGKKEKKKK 536
               |::|:||
  Rat   476 ---KRDKEKK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	148/372 (40%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	112/273 (41%)
Septin6	XP_017457646.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820