DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and SEPTIN4

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001355700.1	Gene:	SEPTIN4 / 5414	HGNCID:	9165	Length:	996	Species:	Homo sapiens

Alignment Length:	427	Identity:	192/427 - (44%)
Similarity:	262/427 - (61%)	Gaps:	56/427 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RPPNQPPS----------VPVAASGKLDTSGGGASNGDSNKLTHDLQEKEHQQAQKPQKPPLPVR 113
            |||::|.|          .|::.|.:..:..|.....||::     .:||
Human   597 RPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSE-----DDKE--------------- 641

  Fly   114 QKPMEIAGYVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSL 178
                    |||||.|||||:||:||:||:|||||.|.||||||||:||:||:|:|...:..|...
Human   642 --------YVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEE 698

  Fly   179 RKKKTVAVEATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYR 243
            |..:||.:....|.::|.||.|.||:||||||||||:|:.||.|:.||:|.::|:|...||.:.|
Human   699 RIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNR 763

  Fly   244 KTISDSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEI 308
            |.|.|:|||||||||:|.||||.|||:..|::|..:||:||::|||||:||.||...|::|..||
Human   764 KNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEI 828

  Fly   309 AQHKIKIYDFPATLEDAAEEAK-TTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENL 372
            ....||||.||....|..|:.| ..|.|:..:||||:|:||::|..|::||||.||||:|||||.
Human   829 EHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENP 893

  Fly   373 THCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSELGLVDGKARLSNK------------- 424
            .||||:.||.|::|||:|||||||...||||||.:.:..:..:..|.|..||
Human   894 GHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPA 958

  Fly   425 -NPLTQMEEEK--REHEQKMKKMEAEMEQVFDMKVKE 458
             .|.|..|.||  ||.::::::|: ||......::||
Human   959 VPPGTDPETEKLIREKDEELRRMQ-EMLHKIQKQMKE 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	180/355 (51%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	150/272 (55%)
SEPTIN4	NP_001355700.1	DUF4655	2..534	CDD:317882
SEPTIN4	NP_001355700.1	Septin	660..932	CDD:307057	150/271 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860