DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and SEPTIN5

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_002679.2	Gene:	SEPTIN5 / 5413	HGNCID:	9164	Length:	369	Species:	Homo sapiens

Alignment Length:	344	Identity:	169/344 - (49%)
Similarity:	241/344 - (70%)	Gaps:	4/344 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 YVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSLRKKKTVAV 186
            |||||.|||||:||:||:||:|||||.|.||||||||::|:||:|:|...:......|..:||.:
Human    24 YVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEI 88

  Fly   187 EATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYRKTISDSRV 251
            ....|.::|.||.|.||:||||||||||:|:.||.||.:|||.::|:|...||.:.||.|.|:||
Human    89 LKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRV 153

  Fly   252 HCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIY 316
            |||||||:|.||||.|:|:..|::|.:|||:||:|||||.:.|.|:...|::|..||.:..|.:|
Human   154 HCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVY 218

  Fly   317 DFPATLEDAAEEAK-TTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENLTHCDFIAL 380
            .||....|..|:.| ..:.|:...||||:|:||::|..|::||||.||||:|||||..||||:.|
Human   219 QFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKL 283

  Fly   381 RNMVIRTHLQDLKDVTNNVHYENYRCRKLSEL-GLVDGKARLSNKNPLTQMEEEKREHEQKMKKM 444
            |||:||||:.||||||.:|||||||...:.:: ..:...:|:.:..|:..:.....|.|:.::..
Human   284 RNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMK 348

  Fly   445 EAEMEQVFDM--KVKEKMQ 461
            :.|:.::.:|  ::|::||
Human   349 DEELRRMQEMLQRMKQQMQ 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	169/344 (49%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	146/272 (54%)
SEPTIN5	NP_002679.2	Septin	42..313	CDD:395596	146/270 (54%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	51..58		5/6 (83%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	108..111		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	189..192		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860