DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and Septin9

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001106958.1	Gene:	Septin9 / 53860	MGIID:	1858222	Length:	583	Species:	Mus musculus

Alignment Length:	426	Identity:	167/426 - (39%)
Similarity:	250/426 - (58%)	Gaps:	35/426 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RDKQQAASASASSATNGSSGSESLVGVGGRPPNQPPSVPVAASGKLDTSGGGAS----------- 83
            |.:..|:.....||...:..:...|.:....|.:.|:.|: .|..|:.|....|
Mouse   165 RVETPASKIPEGSAVPATDAAPKRVEIQVPKPAEAPNCPL-PSQTLENSEAPMSQLQSRLEPRPS 228

  Fly    84 -------NGDSNKLT----HDLQEKEHQQAQKPQKPPLPVRQKPMEIAGYVGFANLPNQVYRKAV 137
                   |.:.:::|    .|:.:.. :.|...|.|.....:.|||. ||||..::..|:.|||:
Mouse   229 VAEVPYRNQEDSEVTPSCVGDMADNP-RDAMLKQAPASRNEKAPMEF-GYVGIDSILEQMRRKAM 291

  Fly   138 KRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSLRKKKTVAVEATKVMLKENGVNLTL 202
            |:||||.:||||.||||||||||::|.|.|......|....|..||:.:::....::|.||.:.|
Mouse   292 KQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIKSITHDIEEKGVRMKL 356

  Fly   203 TVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYR-KTISDSRVHCCLYFIAPSGHGLL 266
            ||:|||||||.::|.|||.||:::::.:||:||..|..:.| |.|.|:|||||||||..:||.|.
Mouse   357 TVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLR 421

  Fly   267 PLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIYDFPATLEDAAEEAKT 331
            ||||..|:.||..||:|||||||||:|.:|...||::|..::..:.|.:|......|| ||:...
Mouse   422 PLDIEFMKRLSKVVNIVPVIAKADTLTLEERVYFKQRITADLLSNGIDVYPQKEFDED-AEDRLV 485

  Fly   332 TQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENLTHCDFIALRNMVIRTHLQDLKDVT 396
            .:..|..:||||||::...:.:||::.||:..||.:||||.|||:|..||:::||||:|::||:|
Mouse   486 NEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDIT 550

  Fly   397 NNVHYENYRCRKLSELGLVDGKARLSN---KNPLTQ 429
            :|:|:|.||.::|:|     |.:.::|   |.|..|
Mouse   551 SNIHFEAYRVKRLNE-----GNSAMANGIEKEPEAQ 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	146/313 (47%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	131/272 (48%)
Septin9	NP_001106958.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..105
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..252		14/86 (16%)
		CDC3	275..580	CDD:227352	145/310 (47%)
		CDC_Septin	293..567	CDD:206649	132/279 (47%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	303..310		5/6 (83%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	360..363		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	442..445		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850