DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and Septin12

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001094335.1	Gene:	Septin12 / 363542	RGDID:	1565511	Length:	356	Species:	Rattus norvegicus

Alignment Length:	316	Identity:	141/316 - (44%)
Similarity:	209/316 - (66%)	Gaps:	17/316 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 AQKPQKPPLPVRQKPMEIAGYVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSD 166
            :.:|..|..|    |.|:.|.||...:.:|:..||:|.||||.:||||.|||||||::|::|.|.
  Rat    11 SSRPSSPRTP----PCEMFGPVGIEAVLDQLRIKAMKTGFEFNIMVVGQSGLGKSTMVNTLFKSK 71

  Fly   167 IYNAEQYPGPSL--RKKKTVAVEATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDS 229
            ::   |.|.|:|  ...:|:.:.:...:::|.|:.|.|||.|||||||.::|..||.|||.|::.
  Rat    72 VW---QSPAPNLDVPMPQTLELHSVTHVIEEKGLKLKLTVTDTPGFGDQINNDKCWDPILSYINQ 133

  Fly   230 KYEEYLTAESRVYR-KTISDSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMT 293
            :||:||..|..:.| :.|.|:|||||:||:.|:||.|.||||..::.|...||:|||||:||::|
  Rat   134 QYEQYLQEELLITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLRRLCRTVNVVPVIARADSLT 198

  Fly   294 PDEVHLFKKQILNEIAQHKIKIYD---FPATLEDAAEEAKTTQNLRSRVPFAVVGANTIIEQDGK 355
            .:|...|:.:|...:..|.|.:|.   |...:.|....:|    :|.::|||||||:.....:|:
  Rat   199 IEERDAFRSRIQQNLKNHCIDVYPQQCFDEDINDRLLNSK----IREQIPFAVVGADREHIVNGR 259

  Fly   356 KVRGRRYPWGLVEVENLTHCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSE 411
            .|.||:..||::||||:.||:|:.||:::||:|||||||:|:||||||||..:|:|
  Rat   260 CVLGRKTKWGIIEVENMAHCEFLLLRDLLIRSHLQDLKDITHNVHYENYRVLRLNE 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	136/297 (46%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	128/277 (46%)
Septin12	NP_001094335.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		4/15 (27%)
		Interaction with SEPTIN7. /evidence=ECO:0000250\|UniProtKB:Q8IYM1	44..317		129/279 (46%)
		CDC_Septin	45..315	CDD:206649	128/276 (46%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	54..61		5/6 (83%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	110..113		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	192..195		1/2 (50%)
		Self-association (via N-terminus) to polymerize octomeric septin 12-7-6-2/4-2/4-6-7-12 filaments. /evidence=ECO:0000250\|UniProtKB:Q8IYM1	256..356		35/60 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820