DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and spn4

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001342848.1	Gene:	spn4 / 2542193	PomBaseID:	SPAC9G1.11c	Length:	380	Species:	Schizosaccharomyces pombe

Alignment Length:	382	Identity:	143/382 - (37%)
Similarity:	228/382 - (59%)	Gaps:	23/382 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 EIAGYVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGP-SLRKK 181
            |...:||.|:||||.::...:.|..||||:.|.|||||:|..|::|.:.|   :.:.|| .:|.|
pombe     4 EETNFVGIADLPNQRHKIVSRNGVAFTLMLCGESGLGKTTFCNTLFSTTI---KSHMGPEKVRAK 65

  Fly   182 ---KTVAVEATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYR 243
               |||.:|.||..|:|...:|.|||:|||||||.::||.||..::|:::.::|.|:..:.:..|
pombe    66 HAEKTVEIEITKAELEEKNFHLRLTVIDTPGFGDFINNSGCWESVVEFIEDQHESYMRQDQQPDR 130

  Fly   244 KTISDSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEI 308
            :.|.|.|:|.||||:.|..:|:.|:|:..|:.:|.:|||:|||||||..|..::.|:|.:|...:
pombe   131 RKIIDMRIHACLYFLRPVRNGVRPMDLEAMKHISKRVNLIPVIAKADMYTRRDLALYKTRISQVL 195

  Fly   309 AQHKIKIYDFPATLEDAAEEAKTTQNLRSRVPFAVVGA-NTIIEQDGKKVRGRRYPWGLVEVENL 372
            ..|::.:|. |...|......:..|.:.:.:|||:||: :.|...||:.|:||.||||:||:||.
pombe   196 EYHQVNVYK-PNMDEGDPVFHRQIQGIINCMPFAIVGSEDDIRTPDGRVVKGREYPWGIVEIENE 259

  Fly   373 THCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSELGLVDGKARLSNKNPLTQMEEEK-RE 436
            .||||..|||::||:.:.||...|....||.||..::        |.|...:..|..::..| :|
pombe   260 EHCDFKQLRNILIRSCMLDLIQTTEEKLYEQYRQEQM--------KVRQYGEPKLRTIDNAKFKE 316

  Fly   437 HEQKMKKMEAEMEQVFDMKVKEKMQKL---RDS-ELELARRHEERKKALELQIRELE 489
            .|:.::|...|..:|.:.:.::..|:|   ||| ..:|..:|.:.|: :||:|..|:
pombe   317 EEENLRKRFTEQVRVEETRFRQWEQRLIAERDSLNKDLEAQHVQIKQ-IELEIERLK 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	138/370 (37%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	114/276 (41%)
spn4	NP_001342848.1	CDC3	6..376	CDD:227352	142/380 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
TreeFam	1	0.960	-	-
	8	7.910