DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and Septin4

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_006532556.1	Gene:	Septin4 / 18952	MGIID:	1270156	Length:	971	Species:	Mus musculus

Alignment Length:	461	Identity:	199/461 - (43%)
Similarity:	265/461 - (57%)	Gaps:	81/461 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GAISALPSTLAQLALRDKQQAASASASSATNGSSGSESLVGVGGRPPNQPPSVPVAASGKLDTSG 79
            |::...||        |.||..||.|                    |..|.|.|.:..||||
Mouse   573 GSLWPQPS--------DSQQYFSAPA--------------------PLSPSSRPRSPWGKLD--- 606

  Fly    80 GGASNGDSNKLTHDLQEKEHQQAQKPQKPPLPVRQKPMEIAGYVGFANLPNQVYRKAVKRGFEFT 144
                       .:|..|.:.:                     |||||.|||||:||:||:||:||
Mouse   607 -----------PYDSSEDDKE---------------------YVGFATLPNQVHRKSVKKGFDFT 639

  Fly   145 LMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSLRKKKTVAVEATKVMLKENGVNLTLTVVDTPG 209
            |||.|.||||||||:||:||:|:|...:..|...|..:||.:....|.::|.||.|.||:|||||
Mouse   640 LMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPG 704

  Fly   210 FGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYRKTISDSRVHCCLYFIAPSGHGLLPLDIACMQ 274
            |||||:|:.||.|:.||:|.::|:|...||.:.||.|.|:|||||||||:|.||||.|||:..|:
Mouse   705 FGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMK 769

  Fly   275 SLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIYDFPATLEDAAEEAK-TTQNLRSR 338
            :|..:||:||::|||||:||.||...|.:|..||....||||.||....|..|:.| ..|.|:..
Mouse   770 ALHQRVNIVPILAKADTLTPPEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKES 834

  Fly   339 VPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENLTHCDFIALRNMVIRTHLQDLKDVTNNVHYEN 403
            :||||:|:||::|..|::||||.||||:|||||..||||:.||.|::|||:|||||||...||||
Mouse   835 IPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYEN 899

  Fly   404 YRCRKLSELGLVDGKARLSNK--------------NPLTQMEEEK--REHEQKMKKMEAEMEQVF 452
            ||.:.:..:..:..|.|..||              .|.|..|.||  ||.::::::|: ||....
Mouse   900 YRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQ-EMLHKI 963

  Fly   453 DMKVKE 458
            ..::||
Mouse   964 QRQMKE 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	180/355 (51%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	150/272 (55%)
Septin4	XP_006532556.1	DUF4655	14..509	CDD:373934
Septin4	XP_006532556.1	Septin	634..914	CDD:366275	150/279 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860