Protein Alignment pnut and SEPTIN1

DIOPT Version :10

• Sequence 1: NP_477064.1
• Gene: pnut / 35801
• FlyBaseID: FBgn0013726
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_443070.6
• Gene: SEPTIN1 / 1731
• HGNCID: 2879
• Length: 372
• Species: Homo sapiens
• Alignment Length: 352
• Identity: 168/352 - (47%)
• Similarity: 242/352 - (68%)
• Gaps: 23/352 - (6%)

  Fly   122 YVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSLRKKKTVAV 186
            |||||.||||::||:||:||:|||||.|.|||||||||||:||:::|...|.|..|.|..:|:|:
Human    10 YVGFAALPNQLHRKSVKKGFDFTLMVAGESGLGKSTLINSLFLTNLYEDRQVPEASARLTQTLAI 74

  Fly   187 EATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYRKTISDSRV 251
            |...|.::|.||.:.||:||||||||:||.|:||:|::::::.::|:||..||.:.||.|.||||
Human    75 ERRGVEIEEGGVKVKLTLVDTPGFGDSVDCSDCWLPVVKFIEEQFEQYLRDESGLNRKNIQDSRV 139

  Fly   252 HCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIY 316
            |||||||:|.|.||.|||:|.::::.:|||::|||.|||.:.|.|....|::|.:::.:.:|.||
Human   140 HCCLYFISPFGRGLRPLDVAFLRAVHEKVNIIPVIGKADALMPQETQALKQKIRDQLKEEEIHIY 204

  Fly   317 DFPATLEDAAEEAKTTQ-NLRSRVPFAVVGANTIIEQDGKK-VRGRRYPWGLVEVENLTHCDFIA 379
            .||....|..|:.|... .::..:||||||:..::...|.: ||||||.||.|||||..||||:.
Human   205 QFPECDSDEDEDFKRQDAEMKESIPFAVVGSCEVVRDGGNRPVRGRRYSWGTVEVENPHHCDFLN 269

  Fly   380 LRNMVIRTHLQDLKDVTNNVHYENYRCRKLSEL---GLVD--GKARLSNKN---------PLTQM 430
            ||.|:::|||||||:||:::.||.||.|.|..|   |..|  .:::||.::         ||...
Human   270 LRRMLVQTHLQDLKEVTHDLLYEGYRARCLQSLARPGARDRASRSKLSRQSATEIPLPMLPLADT 334

  Fly   431 E-------EEKREHEQKMKKMEAEMEQ 450
            |       ||.|..::.::||:|:|:|
Human   335 EKLIREKDEELRRMQEMLEKMQAQMQQ 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	3a0901s04IAP86	58..>210	CDD:273381	52/87 (60%)
		Septin	140..411	CDD:395596	139/272 (51%)
		UDM1_RNF168	427..484	CDD:409018	10/31 (32%)
SEPTIN1	NP_443070.6	Septin	28..301	CDD:395596	139/272 (51%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	37..44		5/6 (83%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	94..97		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	175..178		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..372		5/10 (50%)