Protein Alignment pnut and SEPTIN10

DIOPT Version :9

• Sequence 1: NP_477064.1
• Gene: pnut / 35801
• FlyBaseID: FBgn0013726
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001308427.1
• Gene: SEPTIN10 / 151011
• HGNCID: 14349
• Length: 544
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 167/437 - (38%)
• Similarity: 267/437 - (61%)
• Gaps: 39/437 - (8%)

  Fly   115 KPMEIAGYVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPG---- 175
            :.:.::|:|||.:||:|:..:::::||.|.::.||.:|:||||||:::|.:   |.|.|..
Human    39 RSLTMSGHVGFESLPDQLVNRSIQQGFCFNILCVGETGIGKSTLIDTLFNT---NFEDYESSHFC 100

  Fly   176 PSLRKKKTVAVEATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESR 240
            |:::.|      |....|:|:.|.|.||:|:|.||||.::....:.||::|:|:::|.||..|.:
Human   101 PNVKLK------AQTYELQESNVQLKLTIVNTVGFGDQINKEESYQPIVDYIDAQFEAYLQEELK 159

  Fly   241 VYRK--TISDSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQ 303
            :.|.  |..|||:|.|||||:|:||.|..||:..|::|..|||::||||||||::..|:..||.:
Human   160 IKRSLFTYHDSRIHVCLYFISPTGHSLKTLDLLTMKNLDSKVNIIPVIAKADTVSKTELQKFKIK 224

  Fly   304 ILNEIAQHKIKIYDFPATLEDAAEEAKTTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVE 368
            :::|:..:.::||.|| |.:|..  ||....:..::||||||:...::...|.|:.|:||||:|:
Human   225 LMSELVSNGVQIYQFP-TDDDTI--AKVNAAMNGQLPFAVVGSMDEVKVGNKMVKARQYPWGVVQ 286

  Fly   369 VENLTHCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSELGLVDGKARLSNKNPLTQMEEE 433
            |||..||||:.||.|:|.|:::||::.|:..|||.||..||.|:|..|  ....||....|...|
Human   287 VENENHCDFVKLREMLICTNMEDLREQTHTRHYELYRRCKLEEMGFTD--VGPENKPVSVQETYE 349

  Fly   434 KREHE---QKMKKMEAEMEQVFDMKVKEKMQKLRDSELELARRHEERKKALELQIRELEEKRREF 495
            .:.||   ::.:| |.||:|:|..:||||...|:::|.||..:.|..|:..:.:..:||||||..
Human   350 AKRHEFHGERQRK-EEEMKQMFVQRVKEKEAILKEAERELQAKFEHLKRLHQEERMKLEEKRRLL 413

  Fly   496 ERE------KKEWEDVNHVTLEELKRRSLGANSSTDNVDGKKEKKKK 536
            |.|      ||...::.|       .:|..|..|  |:...|::||:
Human   414 EEEIIAFSKKKATSEIFH-------SQSFLATGS--NLRKDKDRKKE 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	149/369 (40%)
		Septin	139..411	CDD:279124	117/277 (42%)
SEPTIN10	NP_001308427.1	CDC3	44..397	CDD:227352	148/367 (40%)
		CDC_Septin	63..331	CDD:206649	118/279 (42%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	73..80		3/6 (50%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	125..128		1/2 (50%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	208..211		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850