DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pnut and SEPTIN9

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001106963.1	Gene:	SEPTIN9 / 10801	HGNCID:	7323	Length:	586	Species:	Homo sapiens

Alignment Length:	440	Identity:	170/440 - (38%)
Similarity:	258/440 - (58%)	Gaps:	26/440 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSPRSNAVNGGSGGAISALPSTLAQLALRDKQQAASASASSATNGSSGSESLVGVGGR--PPNQ 63
            |..|.|......:..|..|.|..: ::.:....:|.:|.:.:.|..:|....:..:..|  |..|
Human   165 MEPPASKVPEVPTAPATDAAPKRV-EIQMPKPAEAPTAPSPAQTLENSEPAPVSQLQSRLEPKPQ 228

  Fly    64 PPSVPVAASGKLDTSGGGASNGDSNKLTHDLQEKEHQQAQKPQKPPLPVRQKPMEIAGYVGFANL 128
            ||........:..|....:..||......|...|: ..|.:.:|.|:..        ||||..::
Human   229 PPVAEATPRSQEATEAAPSCVGDMADTPRDAGLKQ-APASRNEKAPVDF--------GYVGIDSI 284

  Fly   129 PNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSLRKKKTVAVEATKVML 193
            ..|:.|||:|:||||.:||||.||||||||||::|.|.|......|....|..||:.:::....:
Human   285 LEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIKSITHDI 349

  Fly   194 KENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYR-KTISDSRVHCCLYF 257
            :|.||.:.|||:|||||||.::|.|||.||:::::.:||:||..|..:.| |.|.|:||||||||
Human   350 EEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYF 414

  Fly   258 IAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDE-VHLFKKQILNEIAQHKIKIYDFPAT 321
            |..:||.|.||||..|:.||..||:|||||||||:|.:| || ||::|..::..:.|.:|.....
Human   415 IPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVH-FKQRITADLLSNGIDVYPQKEF 478

  Fly   322 LEDAAEEAKTTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENLTHCDFIALRNMVIR 386
            .|| :|:....:..|..:||||||::...:.:||::.||:..||.:||||.|||:|..||:::||
Human   479 DED-SEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIR 542

  Fly   387 THLQDLKDVTNNVHYENYRCRKLSELGLVDGKARLSNKNPLTQMEEEKRE 436
            ||:|::||:|:::|:|.||.::|:|     |.:.::|     .|||::.|
Human   543 THMQNIKDITSSIHFEAYRVKRLNE-----GSSAMAN-----GMEEKEPE 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	147/318 (46%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	131/273 (48%)
SEPTIN9	NP_001106963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..268		21/104 (20%)
		CDC3	277..583	CDD:227352	147/318 (46%)
		CDC_Septin	295..569	CDD:206649	132/280 (47%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	305..312		5/6 (83%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	362..365		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	444..447		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850