DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and sept4b

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_021336990.1	Gene:	sept4b / 100003446	ZFINID:	ZDB-GENE-071127-1	Length:	508	Species:	Danio rerio

Alignment Length:	490	Identity:	215/490 - (43%)
Similarity:	289/490 - (58%)	Gaps:	79/490 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DKQQAASASASSATNG--------SSGSESLVGVGGRPP-----NQP-----PSVPVAAS----G 73
            |:|.:..||.......        .|....|..:.||||     |:|     |::..||:    |
Zfish    38 DEQDSMPASPEPRARAVEKHLPKEDSEDSELEHIMGRPPPPEGHNRPHTPGTPTLRPAAAPRGPG 102

  Fly    74 KLDTSGGGASNGDSNKLTHDLQEKEHQQAQKPQKPPLP-VRQKPMEIA-----GYVGFANLPNQV 132
            :.::..||........|...:         .|.:|..| .|..|.:..     .|||||.|||||
Zfish   103 EHESRTGGQRGRVEFSLPSPI---------SPSRPKSPWGRYDPYDATEDQDKEYVGFATLPNQV 158

  Fly   133 YRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIY------NAEQYPGPSLRKKKTVAVEATK- 190
            :||:||:||:|||||.|.||||||||:||:||:|:|      |||:        :.|..||.||
Zfish   159 HRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYKDRKLLNAEE--------RITQTVEITKH 215

  Fly   191 -VMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYRKTISDSRVHCC 254
             |.::|.||.|.||:||||||||||:|:.||..:.:|:|.::|:|...||.:.||.|.|:|||||
Zfish   216 TVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKSVADYIDQQFEQYFRDESGLNRKNIQDNRVHCC 280

  Fly   255 LYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIYDFP 319
            ||||:|.||||.|||:..|::|.:|||:|||:|||||:||.||...|.:|..||.|:.||||.||
Zfish   281 LYFISPFGHGLRPLDVEFMKALHEKVNIVPVLAKADTLTPLEVKKKKIKIREEIEQYGIKIYQFP 345

  Fly   320 ATLEDAAEEAK-TTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENLTHCDFIALRNM 383
            ....|..||.| ..|.|:..:||||:|:||::|..||:||||.||||:|||||..||||:.||||
Zfish   346 DCDSDEDEEFKQQDQELKDSIPFAVIGSNTVVEAKGKRVRGRLYPWGIVEVENPAHCDFVKLRNM 410

  Fly   384 VIRTHLQDLKDVTNNVHYENYRCRKLSELGLVDGKARLSNKNPLTQ----------------MEE 432
            ::|||:|||||||...||||||...:..:..:..|.|  |:|.||:                .|.
Zfish   411 LVRTHMQDLKDVTRETHYENYRAHCIQSMTRMVVKER--NRNKLTRESGTDFPIPTAPGVSDSET 473

  Fly   433 EK--REHEQKMKKMEAEMEQVFDMKVKEKMQKLRD 465
            ||  ||.::::::|: ||.|    |::|:|...|:
Zfish   474 EKLIREKDEELRRMQ-EMLQ----KIQEQMHSQRE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	191/372 (51%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	158/280 (56%)
sept4b	XP_021336990.1	Atrophin-1	<12..130	CDD:331285	21/100 (21%)
sept4b	XP_021336990.1	Septin	166..438	CDD:307057	158/279 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930