DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnut and sept7b

DIOPT Version :9

Sequence 1:	NP_477064.1	Gene:	pnut / 35801	FlyBaseID:	FBgn0013726	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_009290954.1	Gene:	sept7b / 100000597	ZFINID:	ZDB-GENE-030131-37	Length:	425	Species:	Danio rerio

Alignment Length:	438	Identity:	276/438 - (63%)
Similarity:	339/438 - (77%)	Gaps:	26/438 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RQKPMEIAGYVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPS 177
            :||.:|  ||||||:||||||||:|||||||||||||.|||||||||||:||:|:|:.| |||||
Zfish     3 QQKNLE--GYVGFASLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSGE-YPGPS 64

  Fly   178 LRKKKTVAVEATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVY 242
            .|.||||.||.:||::||.||.|.|::||||||||||||||||.|:::::|||:|:||.|||||.
Zfish    65 NRIKKTVQVEQSKVLMKEGGVQLLLSIVDTPGFGDAVDNSNCWQPVIDHIDSKFEDYLNAESRVN 129

  Fly   243 RKTISDSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNE 307
            |:.:.||||||||||||||||||.||||..|:.|.:|||::|:||||||:||:|...|||||:.|
Zfish   130 RRQMPDSRVHCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMRE 194

  Fly   308 IAQHKIKIYDFPATLEDAAEEAKTTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENL 372
            |.:||||||:||.|  |..||.|..:.::.|:|.||||:|||||.:|||||||:||||:.||||.
Zfish   195 ILEHKIKIYEFPET--DDEEENKIVKTIKDRLPLAVVGSNTIIEANGKKVRGRQYPWGVAEVENG 257

  Fly   373 THCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSEL---GLVDGKAR--------LSNKNP 426
            .||||..||||:||||:||||||||||||||||.|||:.:   |:.:.||:        :...:|
Zfish   258 DHCDFTLLRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTCNGIDNNKAKGQLTKVDTVEGMSP 322

  Fly   427 LTQMEEEKREHEQKMKKMEAEMEQVFDMKVKEKMQKLRDSELELARRHEERKKALELQIRELEEK 491
            |.|||||:|||..||||||.||||||:||||||:|||:|||.||.||||:.||.||.|.:||||:
Zfish   323 LAQMEEERREHVTKMKKMEMEMEQVFEMKVKEKVQKLKDSEGELQRRHEQMKKNLEAQHKELEER 387

  Fly   492 RREFEREKKEWEDVNHVTLEELKRRSLGANSSTDNVDGKKEKKKKGLF 539
            ||:||.|:..||....: ||:.|...:..         :|.|||..:|
Zfish   388 RRQFEEERSTWETQQRI-LEQQKMYVMTL---------EKNKKKGKIF 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnut	NP_477064.1	CDC3	121..482	CDD:227352	251/371 (68%)
pnut	NP_477064.1	Septin	139..411	CDD:279124	190/271 (70%)
sept7b	XP_009290954.1	CDC3	9..382	CDD:227352	254/375 (68%)
sept7b	XP_009290954.1	CDC_Septin	27..297	CDD:206649	190/272 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	399	1.000	Domainoid score	I702
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1354
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1116
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm25008
orthoMCL	1	0.900	-	-		OOG6_104146
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870