DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and BHLHE40

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_003661.1	Gene:	BHLHE40 / 8553	HGNCID:	1046	Length:	412	Species:	Homo sapiens

Alignment Length:	412	Identity:	91/412 - (22%)
Similarity:	143/412 - (34%)	Gaps:	174/412 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GLSKAE-LRKTNK---PIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHL 94
            |:.::| .::|.|   .::||:||.|||.|:.:||.|:.|.:|.....|  ||||.:||:|:||:
Human    42 GIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLKHV 104

  Fly    95 QSV-----QRQQLNMAIQSD-----------PSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQ 143
            :::     |:||..:|:||.           .:..:.|.:||..||.||.:|:::.:........
Human   105 KALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSS 169

  Fly   144 RLSAHLNQCANSL--------------------------------------------------EQ 158
            :|..||::..:.|                                                  ||
Human   170 QLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQ 234

  Fly   159 IGSMSNFSNGY-----RGGLFPATAVTAAPTPLFPSLPQDLNNNSR-----------TESSAPAI 207
            .||.::..:||     :|.|       .:..|.|.|     ::..|           .||..|..
Human   235 SGSDTDTDSGYGGESEKGDL-------RSEQPCFKS-----DHGRRFTMGERIGAIKQESEEPPT 287

  Fly   208 QMGGLQLI------------------------PSRLPSGEFALIMPNTGSAAP-------PPG-P 240
            :...:||.                        |..||   |.||.|:..:..|       |.. |
Human   288 KKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLP---FYLIPPSATAYLPMLEKCWYPTSVP 349

  Fly   241 FAWPGSAAGVAAGTASAALASIANPTHLNDYTQSFRMSAFSKPVNTSVPANLPENLIHTLPG--- 302
            ..:||..|..||                        :|:|..|...|.|..:|:.|...||.
Human   350 VLYPGLNASAAA------------------------LSSFMNPDKISAPLLMPQRLPSPLPAHPS 390

  Fly   303 -------QTQLPVKNSTSPPLS 317
                   |...|:     |||:
Human   391 VDSSVLLQALKPI-----PPLN 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	27/70 (39%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	12/93 (13%)
BHLHE40	NP_003661.1	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer	1..139		33/98 (34%)
		bHLH-O_DEC1	40..129	CDD:381592	33/88 (38%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269\|PubMed:19786558	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..303		18/132 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910