DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and Hes3

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_073178.1	Gene:	Hes3 / 64628	RGDID:	621339	Length:	175	Species:	Rattus norvegicus

Alignment Length:	200	Identity:	65/200 - (32%)
Similarity:	87/200 - (43%)	Gaps:	53/200 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 MEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSV 112
            |||:||||||..|.:|:|| ||.......|..|||||||||::||:::|:|.....:.:.  ||.
  Rat     1 MEKKRRARINLSLEQLRSL-LERHYSHQIRKRKLEKADILELSVKYVRSLQNSLQGLWLV--PSG 62

  Fly   113 VQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLN----QCANSLE-QIGSMSNFSNGYRGG 172
            |.               |.|...|...|..|||....:    :|...|: :.||.::.:|
  Rat    63 VD---------------YPSGFRGGLPGSSQRLRPGEDDSGLRCPLLLQRRAGSTTDSAN----- 107

  Fly   173 LFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGGLQLIPSRLPSGEF----ALIMPNTGS 233
              |.||     :.|.|.||         ...||....||     |:.|...|    .|:..:||.
  Rat   108 --PQTA-----SVLSPCLP---------AIWAPGPPAGG-----SQSPQSPFPPLGGLLESSTGI 151

  Fly   234 AAPPP 238
            .||||
  Rat   152 LAPPP 156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	29/52 (56%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	9/48 (19%)
Hes3	NP_073178.1	bHLH-O_HES3	1..55	CDD:381503	29/54 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..175		12/37 (32%)
		WRPW motif	172..175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910