DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpn and hey1

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_997726.1	Gene:	hey1 / 58008	ZFINID:	ZDB-GENE-000607-70	Length:	317	Species:	Danio rerio

Alignment Length:	319	Identity:	95/319 - (29%)
Similarity:	141/319 - (44%)	Gaps:	62/319 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NDINSDDDFDCSNGYSD-SYGSN---GRMSNPNGLSKAELRKTNKPIMEKRRRARINHCLNELKS 65
            :|...|::.:.....:| :.|:|   |.|| |:..|:.:.||..:.|:|||||.|||:.|:||:.
Zfish    10 SDSELDENIEVEKESADENAGANSPLGSMS-PSTTSQVQARKRRRGIIEKRRRDRINNSLSELRR 73

  Fly    66 LILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRY 130
            |:..|.:|..:  .|||||:||:|||.||:.:..........:....:.....||.||..|..||
Zfish    74 LVPSAFEKQGS--AKLEKAEILQMTVDHLKMLHAAGGKGYFDAHALAMDYRGLGFRECLAETARY 136

  Fly   131 VSQMDGIDT--GVRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGLFPATAV----------TAAP 183
            :|.::|:|.  .:|.||.:|||..|:..|....:.:.:.|...|..|:...          ..||
Zfish   137 LSIIEGLDNTDPLRIRLVSHLNSYASQREAHSGLGHLAWGSAFGTPPSHLAHHLLLQQQQQQGAP 201

  Fly   184 TPLFPSLPQDLNNNSRTES--SAP-------------AIQMGGLQLIPS-RLPSGEFALIMPNTG 232
            .....|.|...|::|.:.|  |||             |.|.|.|::.|| .||.|    :.|.|.
Zfish   202 LARSTSSPPSSNSSSPSSSSPSAPSTEPRLSGTVISEAGQTGPLRVPPSTSLPPG----LTPPTA 262

  Fly   233 SAAPPP--------GPFAWPGSAAGVAAGTASAALASIANPTHLNDYTQSFRMSAFSKP 283
            |...||        ..|.:|.||            ..:.:|:.|...|.|   |:..||
Zfish   263 SKLSPPLLTSLSSLSAFPFPLSA------------FPLLSPSSLGPATPS---SSLGKP 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	29/61 (48%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	17/45 (38%)
hey1	NP_997726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		14/49 (29%)
		HLH	49..106	CDD:238036	29/58 (50%)
		ORANGE	119..165	CDD:128787	17/45 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..264		21/74 (28%)
		YRPW motif	307..310		95/319 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810