Protein Alignment dpn and HES4

DIOPT Version :9

• Sequence 1: NP_476923.1
• Gene: dpn / 35800
• FlyBaseID: FBgn0010109
• Length: 435
• Species: Drosophila melanogaster
• Sequence 2: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 87/224 - (38%)
• Similarity: 123/224 - (54%)
• Gaps: 44/224 - (19%)

  Fly    24 GSNGRMSNPNGLSKAELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILE 88
            |..||.:.|     ....:::||:||||||||||..|.:||:|||:|::|:.:||:|||||||||
Human    49 GREGRGTQP-----VPDPQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILE 108

  Fly    89 MTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCA 153
            |||:||:|::|.|:..|:.:||:|:.|::.||.||..||||:::..:|:...||.||..||..|
Human   109 MTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAAC- 172

  Fly   154 NSLEQIGSMSNFSNGYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGGLQLIPSR 218
              |.|:|.                  :..|..|.|:.|        .|:.||.: ..|..|:||.
Human   173 --LRQLGP------------------SRRPASLSPAAP--------AEAPAPEV-YAGRPLLPSL 208

  Fly   219 LPSGEFALIMP-------NTGSAAPPPGP 240
              .|.|.|:.|       ....|||..||
Human   209 --GGPFPLLAPPLLPGLTRALPAAPRAGP 235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	38/61 (62%)
		ORANGE	114..158	CDD:128787	18/43 (42%)
HES4	NP_001135939.1	HLH	62..119	CDD:238036	37/56 (66%)
		Hairy_orange	136..174	CDD:284859	16/40 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7601
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4933
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	1	1.000	-	-		otm42263
orthoMCL	1	0.900	-	-		OOG6_105205
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.770