DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and Hes6

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_062352.1	Gene:	Hes6 / 55927	MGIID:	1859852	Length:	224	Species:	Mus musculus

Alignment Length:	206	Identity:	59/206 - (28%)
Similarity:	90/206 - (43%)	Gaps:	34/206 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMA 105
            ||..||::||:||||||..|.||:.|:.....:     .|||.|::||:||:.:|...|.:....
Mouse    26 RKARKPLVEKKRRARINESLQELRLLLAGTEVQ-----AKLENAEVLELTVRRVQGALRGRARER 85

  Fly   106 IQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHL-------------NQCANSLE 157
            .|......::|..|:::|..||:.:||....||..|...|..||             :...:||.
Mouse    86 EQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVSAELLNHLLESMPLREGSSFQDLLGDSLA 150

  Fly   158 QIGSMSNFSNGYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGGLQLIPSRLPSG 222
            .:...|..|:...|| .|.:.:::.|.| ...|..||......|          |..:|:..|.
Mouse   151 GLPGGSGRSSWPPGG-SPESPLSSPPGP-GDDLCSDLEEIPEAE----------LNRVPAEGPD- 202

  Fly   223 EFALIMPNTGS 233
               |:..:.||
Mouse   203 ---LVSTSLGS 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	26/59 (44%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	15/56 (27%)
Hes6	NP_062352.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		2/4 (50%)
		bHLH_SF	24..81	CDD:412148	26/59 (44%)
		Hairy_orange	96..134	CDD:400076	13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..209		17/78 (22%)
		WRPW motif	221..224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810