Protein Alignment dpn and HES2

DIOPT Version :10

• Sequence 1: NP_476923.1
• Gene: dpn / 35800
• FlyBaseID: FBgn0010109
• Length: 435
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 206
• Identity: 68/206 - (33%)
• Similarity: 94/206 - (45%)
• Gaps: 46/206 - (22%)

  Fly    38 AELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQL 102
            |||||:.||::|||||||||..|::||.|||..:.::.:..:||||||:|||||:.||.:.....
Human    11 AELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSW 75

  Fly   103 NMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSN 167
            ..|.   |.....::.|:..|...:.|.:.....::..|..||..||.:.|.|....|..:..|:
Human    76 PTAA---PLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSS 137

  Fly   168 GYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGGLQLIPSRLPSGEFALIMPNTG 232
            |...   ||.|..:||.|                :|||         :||. ||
Human   138 GPSA---PAPAPASAPEP----------------ASAP---------VPSP-PS----------- 162

  Fly   233 SAAPPPGPFAW 243
               ||.||..|
Human   163 ---PPCGPGLW 170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	bHLH-O_hairy_like	39..105	CDD:381483	34/65 (52%)
		ORANGE	114..158	CDD:128787	10/43 (23%)
HES2	NP_061962.2	bHLH-O_HES2	10..74	CDD:381469	35/62 (56%)
		ORANGE	84..127	CDD:128787	10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		21/86 (24%)
		WRPW motif	170..173		1/1 (100%)