DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and hes1

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001011194.1	Gene:	hes1 / 496617	XenbaseID:	XB-GENE-487995	Length:	267	Species:	Xenopus tropicalis

Alignment Length:	264	Identity:	109/264 - (41%)
Similarity:	144/264 - (54%)	Gaps:	44/264 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NGYSDSYGSNGRMSNPNGLSK--AELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHT 79
            |..|....:...|||.....|  :|.||::|||||||||||||..|.:||:|||:|:|||.:||:
Frog     9 NSSSPVAATPASMSNTPDKPKTASEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHS 73

  Fly    80 KLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQR 144
            |||||||||||||||:::||.|:..|:.:||||:.|::.||.||..||.|::|..:|::|.||.|
Frog    74 KLEKADILEMTVKHLRNLQRVQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTDVRTR 138

  Fly   145 LSAHLNQCANSLEQIGSMSNFSNGYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAP-AIQ 208
            |..||..|.|   ||.:| |:...      |.....|||.|.:......|...:...|.|| |.:
Frog   139 LLGHLANCMN---QINAM-NYPTQ------PQIPAAAAPHPAYGQPLVQLQGAAPQSSPAPIACK 193

  Fly   209 M-----------GGLQLIPSRLPSGEFALIM-----PNTGSAAP-----------PP--GPFAWP 244
            |           ||.||:|:  |.|:||.::     |:.||..|           ||  .|...|
Frog   194 MGGPPVEAAKVYGGFQLVPA--PDGQFAFLITNPAFPHNGSVIPVYTNSNVGTALPPSVSPSVMP 256

  Fly   245 GSAA 248
            ...|
Frog   257 SVTA 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	45/61 (74%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	19/43 (44%)
hes1	NP_001011194.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		14/35 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	45/61 (74%)
		Hairy_orange	110..148	CDD:369405	17/37 (46%)
		WRPW motif. /evidence=ECO:0000255	264..267
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7479
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4097
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	1	1.000	-	-		otm49492
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3263
SonicParanoid	1	1.000	-	-		X3450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100