DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and helt

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_996948.1	Gene:	helt / 404275	ZFINID:	ZDB-GENE-040824-6	Length:	270	Species:	Danio rerio

Alignment Length:	257	Identity:	66/257 - (25%)
Similarity:	100/257 - (38%)	Gaps:	72/257 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SKAELRK---TNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSV 97
            ||.:.||   .:..::|||||.|||.|||||...:..|:.|.  ...|||||:||||||::|:::
Zfish    52 SKMKDRKKTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQ--NSGKLEKAEILEMTVQYLRAL 114

  Fly    98 QRQQLNMAIQSDPSVVQ---KFKTGFVECAEEVNRYVSQMDGIDTGVRQ--RLSAHLNQCANSLE 157
            .........:....:.:   .|..|:.||.:.:..|::.::.::|...:  |:.|.|.....:..
Zfish   115 HSADFPRGREKGELLTEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKVVTEP 179

  Fly   158 QIGSMSNFSNGYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGGLQLIPSRLPSG 222
            ..||:.              .::..||.|...|  :..:.|.|||   ..|..
Zfish   180 VFGSLG--------------TISPDPTDLLCQL--EYQSPSPTES---VFQQS------------ 213

  Fly   223 EFALIMPNTGSAAPPPGPFAWPGSAAGVAAGTASAALASIANPTHLNDYTQSFRMSAFSKPV 284
                          |||.|:|..|       |.|..||..|...|          |.:..||
Zfish   214 --------------PPGHFSWHSS-------TRSPTLAYPAMSQH----------SGYLSPV 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	29/64 (45%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	9/48 (19%)
helt	NP_996948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		HLH	62..115	CDD:278439	27/54 (50%)
		Hairy_orange	136..173	CDD:284859	9/36 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810