DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpn and HES3

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001019769.1	Gene:	HES3 / 390992	HGNCID:	26226	Length:	186	Species:	Homo sapiens

Alignment Length:	221	Identity:	67/221 - (30%)
Similarity:	88/221 - (39%)	Gaps:	90/221 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 MEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQ----- 107
            |||:||||||..|.:|||| ||.......|..|||||||||::||:::|:|.     ::|
Human     1 MEKKRRARINVSLEQLKSL-LEKHYSHQIRKRKLEKADILELSVKYMRSLQN-----SLQGLWPV 59

  Fly   108 ----SDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRL-----------SAHLNQCANSLE 157
                ..||       ||..|...|::.:.:.|.:.:|:|..|           ||.|.|.|.:|
Human    60 PRGAEQPS-------GFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGLGQEAPAL- 116

  Fly   158 QIGSMSNFSNGYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGG------LQLIP 216
                       :|    |.|....||.|                      ..||      |.|:|
Human   117 -----------FR----PCTPAVWAPAP----------------------AAGGPRSPPPLLLLP 144

  Fly   217 SRLPSGEFALIMPNTGSAA--PPPGP 240
            ..||           ||:|  |||.|
Human   145 ESLP-----------GSSASVPPPQP 159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	30/52 (58%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	14/54 (26%)
HES3	NP_001019769.1	HLH	1..54	CDD:238036	30/58 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..186		15/65 (23%)
		WRPW motif	175..178
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910