DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and h

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	406	Identity:	130/406 - (32%)
Similarity:	178/406 - (43%)	Gaps:	111/406 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMA 105
            |::||||||||||||||:||||||:|||:|.|||||||:|||||||||.||||||.:||||..|.
  Fly    32 RRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQ 96

  Fly   106 IQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSNGYR 170
            ..:||.:|.|||.||.:|..||:|:    .||:...|:||..||:.|.|     |..:......|
  Fly    97 QAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQRRRLLQHLSNCIN-----GVKTELHQQQR 152

  Fly   171 GGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAP---AIQM--------GGLQLIPSRLPSGEF 224
            .....:......|:|  ||.|:   .:|:..::||   .||.        .|:|:||::||:|..
  Fly   153 QQQQQSIHAQMLPSP--PSSPE---QDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSI 212

  Fly   225 ALIMPNTGSAAPPPGPFAWPGSAAGVAAGTASAALASIANPTHLNDYTQSFRMSAFSKPVNTSVP 289
            ||::|.:..................:|...|:||.|                 :|..:|:..|:|
  Fly   213 ALVLPQSLPQQQQQQLLQHQQQQQQLAVAAAAAAAA-----------------AAQQQPMLVSMP 260

  Fly   290 ANLPENLIHTLPGQTQLPVKNSTSPPLSPISSISSHCEESRAASPTVDVMSKHSFAGVFSTPPPT 354
                                                   .|.||  ....|.||.|| :.:.|.:
  Fly   261 ---------------------------------------QRTAS--TGSASSHSSAG-YESAPGS 283

  Fly   355 SAETSFNTSGSLNLSAGSHDSSGCSRPLAHLQQQQVSSTSGIAKRDREAEAESSDCSLDEPSSKK 419
            |:..|:......|.|....|..........::||.:|..  |.|:.:|.|         :|
  Fly   284 SSSCSYAPPSPANSSYEPMDIKPSVIQRVPMEQQPLSLV--IKKQIKEEE---------QP---- 333

  Fly   420 FLAGAIEKSSSAWRPW 435
                        ||||
  Fly   334 ------------WRPW 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	49/59 (83%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	18/43 (42%)
h	NP_001014577.1	HLH	29..88	CDD:238036	47/55 (85%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	17/38 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445399
Domainoid	1	1.000	45	1.000	Domainoid score	I4621
eggNOG	1	0.900	-	-		E1_KOG4304
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4933
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105111at33392
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105205
Panther	1	1.100	-	-	P	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3450
	10	9.700