DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and HES1

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_005515.1	Gene:	HES1 / 3280	HGNCID:	5192	Length:	280	Species:	Homo sapiens

Alignment Length:	256	Identity:	104/256 - (40%)
Similarity:	145/256 - (56%)	Gaps:	54/256 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQL 102
            :|.||::|||||||||||||..|::||:|||:|:|||.:||:|||||||||||||||:::||.|:
Human    32 SEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQM 96

  Fly   103 NMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSN 167
            ..|:.:||||:.|::.||.||..||.|::|..:|::|.||.||..||   ||.:.||.:|:
Human    97 TAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHL---ANCMTQINAMT---- 154

  Fly   168 GYRGGLFPAT---------------AVTAAPTPLFP----------SLPQDLNNNSRTESSAPAI 207
             |.|...||.               |..|.|.||.|          ..|..|.    :::...|.
Human   155 -YPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLG----SQAGEAAK 214

  Fly   208 QMGGLQLIPSRLPSGEFALIMPNTGSAAPPPGPFAWPG-------SAAGVAAGTASAALAS 261
            ..||.|::|:  |.|:||.::||        |.||..|       |.:|.:.|..:.:.:|
Human   215 VFGGFQVVPA--PDGQFAFLIPN--------GAFAHSGPVIPVYTSNSGTSVGPNAVSPSS 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	45/61 (74%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	19/43 (44%)
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		7/11 (64%)
		bHLH-O_HES1_4	33..95	CDD:381465	45/61 (74%)
		Hairy_orange	110..148	CDD:400076	18/40 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..200		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..280		2/12 (17%)
		WRPW motif	275..278
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7601
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	1	1.000	-	-		otm42263
orthoMCL	1	0.900	-	-		OOG6_105205
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3263
SonicParanoid	1	1.000	-	-		X3450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.850