DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and her6

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_571154.2	Gene:	her6 / 30288	ZFINID:	ZDB-GENE-980526-144	Length:	270	Species:	Danio rerio

Alignment Length:	248	Identity:	102/248 - (41%)
Similarity:	143/248 - (57%)	Gaps:	30/248 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQL 102
            :|.||::|||||||||||||..|.:||:|||:|:|||.:||:|||||||||||||||:::||.|:
Zfish    32 SEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNMQRAQM 96

  Fly   103 NMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSN 167
            ..|:.:||:|:.|::.||.||..||.|::|..:|::|.||.||..||..|   :.||.:| |:..
Zfish    97 TAALNTDPTVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLASC---MTQINAM-NYPT 157

  Fly   168 GYRGGLFPATAVTAAPTPLFPSLPQDLN------------NNSRTESSAPAIQMGGLQLIPSRLP 220
            .::....|.....:.|....||..|..|            ::|...|.|..: .||.||:|:  .
Zfish   158 QHQIPAGPPHPSFSQPMVQIPSATQQANVVPLSGVPCKSGSSSNLTSDATKV-YGGFQLVPA--T 219

  Fly   221 SGEFALIMPNTGSAAPPPGPFAWPGSA--------AGVAAGTASAALASIANP 265
            .|:||.::||  :|..|.||.. |..|        ..|:.|..|....|:..|
Zfish   220 DGQFAFLIPN--AAFAPNGPVI-PVYANNSNTPVPVAVSPGAPSVTSDSVWRP 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	45/61 (74%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	18/43 (42%)
her6	NP_571154.2	HLH	32..95	CDD:238036	45/62 (73%)
her6	NP_571154.2	Hairy_orange	110..148	CDD:284859	17/40 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7581
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4258
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	1	1.000	-	-		otm26383
orthoMCL	1	0.900	-	-		OOG6_105205
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3263
SonicParanoid	1	1.000	-	-		X3450
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.900