DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpn and HEY2

DIOPT Version :9

Sequence 1:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_036391.1	Gene:	HEY2 / 23493	HGNCID:	4881	Length:	337	Species:	Homo sapiens

Alignment Length:	336	Identity:	106/336 - (31%)
Similarity:	157/336 - (46%)	Gaps:	47/336 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNDINSDDDFDCSNGYS-DSYGSNGRMSNPNGLSKAELRKTNKPIMEKRRRARINHCLNELKSLI 67
            ::|::...|....|.|| .|..|..|:::|...|:...||..:.|:|||||.|||:.|:||:.|:
Human    11 ESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLV 75

  Fly    68 LEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVS 132
            ..|.:|..:  .|||||:||:|||.||:.:|.........:....:.....||.||..||.||:|
Human    76 PTAFEKQGS--AKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLS 138

  Fly   133 QMDGIDTG--VRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGLFP---ATAVTAAPTPLFPSLPQ 192
            .::|:|:.  :|.||.:||:.||...|.....|:.:: :...|.|   |.|....|..|..  |.
Human   139 SVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAH-HHHPLHPHHWAAAFHHLPAALLQ--PN 200

  Fly   193 DLNNN-------SRTESSAPAIQMGGLQLIPSRLPSGEFALIMPNTGSAAP--PPGPFAWPGSAA 248
            .|:.:       |.|....||   .|..|:.:.....:.||.||:|||.||  ||...:....:|
Human   201 GLHASESTPCRLSTTSEVPPA---HGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSA 262

  Fly   249 GVAAGTASAALASIANPTHLNDYTQSFRMSAFSKPVNTSVPANLPENLIHTLPGQTQLPVKNSTS 313
            .|.|..|:|..|:.:.|.   .:..:|.|              ||.|....:...|.:      |
Human   263 TVHAAAAAATAAAHSFPL---SFAGAFPM--------------LPPNAAAAVAAATAI------S 304

  Fly   314 PPLSPISSISS 324
            |||| :|:.||
Human   305 PPLS-VSATSS 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpn	NP_476923.1	HLH	39..101	CDD:238036	30/61 (49%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	18/45 (40%)
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		12/40 (30%)
		bHLH-O_HEY2	40..121	CDD:381490	32/82 (39%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		30/70 (43%)
		ORANGE	119..165	CDD:128787	18/45 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..337		5/9 (56%)
		YRPW motif	327..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810