DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpn and Hes1

DIOPT Version :9

Sequence 1:NP_476923.1 Gene:dpn / 35800 FlyBaseID:FBgn0010109 Length:435 Species:Drosophila melanogaster
Sequence 2:NP_032261.1 Gene:Hes1 / 15205 MGIID:104853 Length:282 Species:Mus musculus


Alignment Length:254 Identity:104/254 - (40%)
Similarity:144/254 - (56%) Gaps:48/254 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 AELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQL 102
            :|.||::|||||||||||||..|::||:|||:|:|||.:||:|||||||||||||||:::||.|:
Mouse    32 SEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQM 96

  Fly   103 NMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSN 167
            ..|:.:||||:.|::.||.||..||.|::|..:|::|.||.||..||   ||.:.||.:|:    
Mouse    97 TAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHL---ANCMTQINAMT---- 154

  Fly   168 GYRGGLFPATAVTAAPTPLFPSLPQDL-------------NNNSRTESSAP----------AIQM 209
             |.|...||......|.|..|:.||..             ...:....|||          |...
Mouse   155 -YPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVF 218

  Fly   210 GGLQLIPSRLPSGEFALIMPNTGSAAPPPGPFAWPG-------SAAGVAAGTASAALAS 261
            ||.|::|:  |.|:||.::||        |.||..|       |.:|.:.|..:.:.:|
Mouse   219 GGFQVVPA--PDGQFAFLIPN--------GAFAHSGPVIPVYTSNSGTSVGPNAVSPSS 267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpnNP_476923.1 HLH 39..101 CDD:238036 45/61 (74%)
ORANGE 114..158 CDD:128787 19/43 (44%)
Hes1NP_032261.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44 7/11 (64%)
HLH 32..95 CDD:238036 45/62 (73%)
Hairy_orange 110..148 CDD:284859 18/40 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 158..204 8/45 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 256..282 2/12 (17%)
WRPW motif 277..280
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 92 1.000 Domainoid score I7591
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4933
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1427802at2759
OrthoFinder 1 1.000 - - FOG0000785
OrthoInspector 1 1.000 - - oto95339
orthoMCL 1 0.900 - - OOG6_105205
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3263
SonicParanoid 1 1.000 - - X3450
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.800

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