DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP1 and mgl

DIOPT Version :9

Sequence 1:	NP_001260800.2	Gene:	LRP1 / 35799	FlyBaseID:	FBgn0053087	Length:	4752	Species:	Drosophila melanogaster
Sequence 2:	NP_001096924.2	Gene:	mgl / 8674055	FlyBaseID:	FBgn0261260	Length:	4769	Species:	Drosophila melanogaster

Alignment Length:	4822	Identity:	1481/4822 - (30%)
Similarity:	2211/4822 - (45%)	Gaps:	858/4822 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SSNSSGRINSR-----SSSSGYRKVQWQEQQEAP--------------------------TLRPL 55
            ||:||..|..|     |||:..|::|.|:..::|                          ||..:
  Fly    63 SSSSSSPIGDRHSQHHSSSAIDRRLQQQQHHQSPQHHRQRGQLTTLALLLLALVAISNLETLLAV 127

  Fly    56 PDKG--NAHKSRNRIKPTVFIRPNAALTAGGG-------PCPASYFTCNDGFCIPMRWKCDSKAD 111
            ..:|  |.|.|           |..:|.:.||       .||...|.||:|.||...|.|:.:.|
  Fly   128 RTEGPRNRHGS-----------PGGSLASTGGSSSGINTECPTDSFRCNNGKCISHHWVCNYQKD 181

  Fly   112 CPDMSDEGSEC-APKCNEGQFRCG---------VSRH---------------------------- 138
            |.|..||...| .|:|...|..||         :..|
  Fly   182 CDDGEDEMQSCPPPECETPQLNCGQYTFNKTYCIPPHYRCDMIEDCEDKSDEAQCTYRKCQHTDL 246

  Fly   139 ------------------CIPNNWLCDGEFDC--GKGDIS--------DELNCPNG--------- 166
                              |:|....|||..||  |:.::.        |:..|.||
  Fly   247 FCNTPTGAPAEGARLTGPCVPKEKRCDGYLDCRTGRDEVGCSGVACRLDQFRCANGLKCIDAALK 311

  Fly   167 ----------------DTPKCRAFEGQCRNGDCLELSRFCDGRWDC--DNDELQC---------- 203
                            :.|.|...:.:|.|..|:..:..|||..||  .:||..|
  Fly   312 CNHRDDCGDNSDEQGCNFPPCHHAQFRCTNALCIPYNFHCDGYHDCADKSDEANCTAIACPDNKH 376

  Fly   204 ------------------------------DKQN----AACAALNCSFNCKLTPQGARCYCPKDQ 234
                                          |::.    |:|.||:|.|.|..:..|..|||...|
  Fly   377 LCPRGGASGTPKCILKSQLCDGKRDCEDGSDEETNCSIASCPALSCEFKCGPSLTGGVCYCKPGQ 441

  Fly   235 VPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNRCRAINVPPTEPTTLIFL 299
            .....|.| |||.|||:|.|.|||:|.||.|||.|.|..||.....::|.|   |......|||.
  Fly   442 SLAPDNRT-CVDLDECAEWGHCDQLCTNTLGSYTCQCAQGYTLINDSKCIA---PDANNLQLIFA 502

  Fly   300 SRDGVQSVGTNGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLF 364
            ....:..:..:|:|    |....|  .|...||                   .:|..|   :.|:
  Fly   503 HDRAIMRMLPHGSE----PKILAN--ATAAAGV-------------------TFHYAR---NTLY 539

  Fly   365 SWPELQMRCQRVD----DARVNWTLPFSSFVSPQQFFTELRLDW-------------------LS 406
             |.:::.|  :|.    ||:.....||...:........|.:||                   ||
  Fly   540 -WSDIKTR--KVQSLPLDAQNKAVSPFDQTLPGTWAPVALAVDWVGDKIYVADLVGQKIDVFELS 601

  Fly   407 GNWYLVSEDDGLVYLCTNAMTYCRVILQQVDPLSSLDLDPTKGFMFYTDWTPSLSRSLLDGSNRT 471
            |.|:.|                  |:...:...:.|.||||.|.||..|....| |:.:||::..
  Fly   602 GQWHAV------------------VLGSNLTSPADLALDPTAGLMFVADGGQVL-RAHMDGTHAR 647

  Fly   472 VLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFE 536
            .:|::..|..|.||:|:.::.|:|.|...|.:..|||||.:|..:.|....|.|.:    :.:||
  Fly   648 SIVSEAAYKASGVTVDIISKRVFWCDSLLDYIESVDYEGAHRVMVLRGQQVPSPSR----LALFE 708

  Fly   537 NSIYLAAWMDT---AIVALDKF----SLKTHILQSNVSRGANLRIFHRQKQPEVAHPCRDNNAGC 594
            |.||   |.|.   .|:::|||    |::......::.....:...|...||.|::||.:||.||
  Fly   709 NRIY---WTDATKQGIMSVDKFEGPTSIQVTYKAKDIREPKGIIAVHALSQPRVSNPCGNNNGGC 770

  Fly   595 NQICVPQWTKGFASA---KCMCTAGYKLHNQTTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQ 656
            |.:|:....||..:.   :|.|:.||:|..... |...:.:||:||.:..  |.|        :.
  Fly   771 NHMCIVTAVKGAPTGLGFRCACSTGYQLETDLK-LCKPVSEFLMYSQQRF--IKG--------KV 824

  Fly   657 LEQIGEQ-PDVMVPVYN-VSKTLAIDVNVRGKAVFY--VVADSGASPFGNGEPSCSIRSQSLNGS 717
            ||.:.|. .|.::||.: .::.:.:|.:.|.:.::|  |:.|             .|.....||:
  Fly   825 LEPVIEGFSDAIMPVVSRRARFVGLDFDARDEFIYYSDVLQD-------------VIYRVHRNGT 876

  Fly   718 VSRL-LAQGLKRVHAVAFDWINDHLYWTSHKK--MQVAPLRNLSKVLTFNTDCD-AMSLELDPTT 778
            ...: ||...:.|..:|.||.:.:||:...:|  :.|...||::...|...:.. ..::.:.|..
  Fly   877 GREIVLASQNEGVEGLAVDWASKNLYYIDSRKGTLNVLSTRNVTHRRTLLKNLKRPRAIVVHPNR 941

  Fly   779 GLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIE 843
            |.:::|:|:.   .|.|..:..||:  .||.  ..::.:.||..|.:|.:...:||||..|..::
  Fly   942 GFIFFSEWDR---PANITRANTDGS--GLLV--FKNVTLGWPNGLSIDFKEDRVYWCDALLDHVQ 999

  Fly   844 LMRLDGTGREVLFKSDQFHPYSIVQNNGLIYWADNKNSTILRFH---AHQANLSSTFSSTVHLQR 905
            ...||||..:.:......||:|||.:|..:|..|.:...|:|.|   ..|..:      .|...:
  Fly  1000 HANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWRLDAIIRLHKLTGEQEEM------MVREPQ 1058

  Fly   906 TGRAADLRIFDIASQPLPQTPSACAQSK--CPGMCLNTPKGAI-------------------CRC 949
            |.|...::::....|.:..| ..|.::.  |..:|...|.||.                   |.|
  Fly  1059 TNRLYGVKVYSHEVQRIADT-QPCHRNNGGCQKICFAVPIGASNGTDGVTTSSPSFGRLQSRCSC 1122

  Fly   950 PDGFTLNGTGSHCIPQ-LAPSPIRPNCTSG--YMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPK 1011
            |.|..|......|||. .|..|::| |.:.  :.|.:.| |:....:|||.:||.|..||..:
  Fly  1123 PYGERLADDQVSCIPDPSAEPPVQP-CPNSWDFTCNNQR-CIPKSWLCDGDDDCLDNSDEEQN-- 1183

  Fly  1012 GPCNVNTCDKTHNFVC-NGRCYQRSLLCSTIPYCSDGTDQANCHQNTCNSNEFTCHKSGRCIQLT 1075
              |...||. ::.|.| :|||..::..|.....|.|.:|:..|...||.:::|.| .:||||...
  Fly  1184 --CTKPTCG-SNEFQCRSGRCIPQNFRCDQENDCGDNSDEQECGNVTCGTSQFAC-ANGRCIPNM 1244

  Fly  1076 WVNDGVVDCGPDDDSDE----TSET--IFASKCPEFDCNNGRCRQFADVCDGIDNCGNNADEMEC 1134
            |..|...|||  |.|||    ..:|  .|...||    ..|.|...:.||||.|:|.:..||.:|
  Fly  1245 WKCDSENDCG--DSSDEGDFCAEKTCAYFQFTCP----RTGHCIPQSWVCDGDDDCFDKQDEKDC 1303

  Fly  1135 EQ-ECEHGEKYCRPI-GCYGEMHMCDGIHDCLDFSDEANC-----NQTKSDNHPVTEWKELGECA 1192
            .. .|...:..|..: .|..|.:.||||.||.|.|||..|     ||...:.|
  Fly  1304 PPISCLANQFKCADLRQCVEESYKCDGIPDCNDGSDEVGCPSMGPNQCNLEKH------------ 1356

  Fly  1193 PLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTR--FDMNET------VIC------- 1242
               |.|.....|||....|||.:.|.|.:||.:|..|...:  |..|.|      .||
  Fly  1357 ---FRCKSTGFCIPIAWHCDGSNDCSDHSDEQDCGQITCAQNFFKCNNTNCVFKAYICDGKDDCG 1418

  Fly  1243 -------EH----PDRLC--------GFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCD-RGH 1287
                   ||    |...|        |.|::||.:..:||...||.:.:|||..|....|: :..
  Fly  1419 DNSDEGAEHACVPPPFKCPHGQWQCPGVSERCVNITSVCDDTPDCPNGSDEGEGCDLAECEHQAG 1483

  Fly  1288 ECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGF 1352
            :||..|..||.|.:|.||....:..:|..|...:.||....|||.|.::...|.|.|.||:.|..
  Fly  1484 QCSSFCQKTPNGALCVCPPGSEIGEDGYTCIDSNECDPPGLCSQQCTNTKGSYFCSCTDGYVLEP 1548

  Fly  1353 DRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVE---IYWTD 1414
            ::.|||:......::|.:||..|...:||...:......:.|::|      ..||:.   |:|:|
  Fly  1549 NKHTCKAVNHTAAFLIISNRHSILVADLKEQGLERVPIIVENVVA------TASNMHTGTIFWSD 1607

  Fly  1415 VIDDKIYRGHLVGESLRNVE--AVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRR 1477
            :...||.|..      |.:|  .:|::||...||||.||:.:||||:||.|:.|||:..|||.|.
  Fly  1608 MKLKKISRLD------RGMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRL 1666

  Fly  1478 TLIAGNMESPRAIALDPREGL--LFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTL 1540
            .|:..|:..||.:.:||..|.  :|||||.:| ||:||..|.|..|:.|..:   ...|||||||
  Fly  1667 VLVRENITQPRGMCIDPSPGARWIFWTDWGEN-PRVERIGMDGTMRKTIINT---KIYWPNGLTL 1727

  Fly  1541 DYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANK 1605
            |...||||:.|:|.|.|....|:|:....||.:...|.||.::|:||:.:||||.:...|:.|||
  Fly  1728 DIATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANK 1792

  Fly  1606 WNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGT--FKCECPHVMRL 1668
            :.|.:..|:....|||..|.|.|:|.||...|||..:.  |.||||||....  :.|:|....:|
  Fly  1793 FRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCAGSR--CQHLCLLSPSAPEGYSCKCRPGFKL 1855

  Fly  1669 DPANERNCVPNEQVLLFV-----MVD-EIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESR 1727
              .:|..|:..|...|.|     :|| .:.|.|........:..|..|..|      ||......
  Fly  1856 --LSEGRCIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGL------DFDRKGET 1912

  Fly  1728 IFWSDIQQ----------------NEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSG 1776
            ::|...::                |:....||.||:        :..||..|.||:.||:|..
  Fly  1913 LYWVQGREDDDENCTIYTTPYGGGNKTLFLGIENGI--------VGAPYTIAFDWLGRNLYIG-- 1967

  Fly  1777 QIKCNILASNL-------KGEFASII------HEDLNMVDSIVLDPANGKMYWIHSASDGSMS-- 1826
                |.:|||:       |.::.:||      ...::....|.|||..||::||   .:|.:.
  Fly  1968 ----NRVASNIEAVRVDGKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWI---DEGVLEVP 2025

  Fly  1827 -QLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSG-IAYYDIPRNETRKVLV--ASP 1887
             ::.:.:::|.:..:::|...:.:||.:|.:.:.:||:..|.. |...|...::...:|:  :.|
  Fly  2026 IKIGRVDMNGQNPIVVFQEFAHPESLAVDTEKKMVYYSASNPAVIGVMDYNGDDHTLILMKDSHP 2090

  Fly  1888 ITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEW 1952
            :....||.:.:..||:.:.:...|::.:.....|...:..|...::|| |.|.......:.|.
  Fly  2091 MAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSM-MIYKKRALMQHPCQ-- 2152

  Fly  1953 AYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYS-IDVLQGVEMIDPSEQFDT 2016
            ...|||:.||:........|.|.:||..|  |...||....|...| :|:::|..:.|.||
  Fly  2153 TNNGGCKHLCIPGPGATRTCACGIGYRKE--NEINCVAYKIFAVVSQLDMIRGYSLSDSSE---- 2211

  Fly  2017 PSPALVPISRVS-SASFIDYLANTDTLYWGDNELG---SISRVKRDGTQRETILEALNLVGYKQQ 2077
               |:||||... ....:|.:.....:||.:...|   .|.|.:.:||..:.::          :
  Fly  2212 ---AMVPISGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQHVV----------K 2263

  Fly  2078 DWLG-----GIAIDWVAGNIYWSDT--KRNIIEVARLDGSHRYVVV-SNLEKPTALAVDPLQGLL 2134
            |.:|     |:.|||||||:|:::.  ..|.:||..||||:|.|:| :..:.|..|||:|::.||
  Fly  2264 DGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLL 2328

  Fly  2135 FYVTQ-QH--IGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGNL 2196
            :::.. ||  ||:..||||:...||  |........|.:|::...:||.:...|.:.|:.|:|..
  Fly  2329 YWIDYGQHPRIGKALLDGSKWTPLV--TSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISYNGAN 2391

  Fly  2197 REQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIY--S 2259
            | :::...|.||:.:|...:.:||.:.  |...:..|...:.:::...::|..:.:||:.||  :
  Fly  2392 R-KIIRRDLPNPMGIAVYLNDVYWVDR--NLMTVFKASKHSANETATSVRTNLEKLRDIAIYNIN 2453

  Fly  2260 KHLQRGSNPCAH-SNGACEQLCL-------FNGTSA----VCACAHSRLASDGYSCEPYENFLLF 2312
            ...|..:||||| .||.|:|||.       .:|||.    .|.||..:|::|...||....:|:|
  Fly  2454 NQPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTSGGRNFRCECATGKLSADERKCEVVNEYLVF 2518

  Fly  2313 SYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQ-LSTINQVHFNGTG 2376
            :.|:.|.::::..|:.: .|...::|   :.||:.:.:::....:.|:.:: .:.|.....|..|
  Fly  2519 ATRTEIRAVNLDPHSTE-VPFTPLTN---LTNVVGLDFDFAHNRMLYTQIRPWAKIAYTKANKPG 2579

  Fly  2377 H---RVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQ-VHVKKVLSLRED 2437
            |   .|:|.:....||:|||...::::||.::|.:|.::.|       |.:: |.:.:|
  Fly  2580 HDDITVVLNKGINPEGIAYDWTQQKIYWTDSSNNSIYAMNL-------DGSELVMIARV------ 2631

  Fly  2438 DKPRGIAVEPCLGMIYWTNWNE--GSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWA 2500
            ::||.|.::||.|.:::|:|..  .|..|.|:.:.|.....|:..|:..|:.|.:|.::::|||.
  Fly  2632 ERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWT 2696

  Fly  2501 DARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREH 2565
            ||..:||||::.||.||.:|..:| .:.||:.|:.:.::|||..|..|.||.|:||.:::   |.
  Fly  2697 DAVREKIERSDLDGQNRELLVAAT-IYPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMV---EM 2757

  Fly  2566 VTR----PMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGV-LAPDGRRCIAP 2625
            |.|    |..|....:....|:.|.|:|.||.|...|....:|:|.|.|.... :..:||.| ||
  Fly  2758 VKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAECKCDDSTKVVNEGRMC-AP 2821

  Fly  2626 VNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKC 2690
            .|.:|..|::.|.:|.||....:||....|.|.|||..:||.:..|....|.|.|.|||.|..||
  Fly  2822 RNNTCEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKC 2886

  Fly  2691 DGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRD--F 2753
            |.|..|.|||||  |.|        ::|..     :...|.|.:|.|||:..:|:.:.||:|  .
  Fly  2887 DHENDCKDGSDE--LGC--------VYPPC-----VDGEFTCANGRCIPQAQVCNGVNDCKDNAT 2936

  Fly  2754 SDE--KMCAPI--PCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDE--LDCANHTSLSCDP 2812
            |||  :.| |:  .|..|.:   .|..:.||:.|.|.||||.||.|.:||  |.|...|   |..
  Fly  2937 SDETHERC-PMNTTCPANHL---KCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRT---CPT 2994

  Fly  2813 GQFRCASGNCIAGSWHCDGEKDCPDGSDE--INCRTE---CRHNQFACDK-TCIPASWQCDGKSD 2871
            ..|||.:..||..:|:|||:.||.||:||  ..|::|   |..:.|.||. .|||..:.|||.:|
  Fly  2995 NSFRCPNHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDND 3059

  Fly  2872 CEDGSDEG--PQCPNRPCRPHL-FQCKSS-----GRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQ 2928
            |.|.|||.  .||.:|.|.... |.|..:     .:|||:||:|||:.||..|      .||...
  Fly  3060 CLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDG------ADENTT 3118

  Fly  2929 CGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQD 2993
            ....|....|......|.:|.||:..::||.|.||..|.||.:.|...::  :|.....  .||:
  Fly  3119 LHNCATQQPCGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYK--TCSAQEF--TCQN 3179

  Fly  2994 GLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDE 3058
            ..||.....|||:.||||.|||..  ||..........|.|.||.||..:|:|::..||||.|||
  Fly  3180 FKCIRNQSRCDGEDDCGDHSDEVG--CAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADESDE 3242

  Fly  3059 EL-CNVNECLIPDI--CEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQ-PCSQTCIN 3119
            .. |||:||...:|  |.|:|.|.:.||.|.|..|||:|... ..|.|:|||.||. .|||.|.|
  Fly  3243 PAHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADG-KACADVDECLEQPGACSQHCSN 3306

  Fly  3120 TYGSYKCLCAKGY--ALVDHHTCKATSNVSMELIFSNRYYIRQVDMTGNG-SILINELSNAVALD 3181
            |.|.:.|.|.:.|  ...|.||||....:...|||:|:||:|.:.:.|:. :::..:|.|.||||
  Fly  3307 TPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALD 3371

  Fly  3182 YDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNP----DGLAVDWVAKNLYWCDKGLD 3242
            :|...:.:|:.|||:......:|...:::.....:|::::.    :|:|:|||.:.|||.|:...
  Fly  3372 FDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSK 3436

  Fly  3243 TIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMII--RDG 3305
            .::||:|||..||.|.:..: :||.|.:||...:::::.|....:|.|.||||||...|:  .||
  Fly  3437 NLDVSELDGSKRKTLRSGVV-DPRAIVVHPGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDG 3500

  Fly  3306 LGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYW 3370
            :.|||||:|.:.|.:::|.||..|.|:.:||:|.|...:|:.|..|     |:||:::::.:|||
  Fly  3501 IAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSKVP-----HVFALSLFDDYIYW 3560

  Fly  3371 SDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSP- 3432
            |||..|:|...:.|:|.|.|.|..|.|||.||.:.||.| |.|.: |||...|  ||.||:::|
  Fly  3561 SDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLR-QLPYT-NPCGTNNGGCSHLCLIAPP 3623

  Fly  3433 ------------EE--PYYKCMCPTNFILADDGRTCRANCTAAHFEC-VNTYKCIPFYWRCDTQD 3482
                        ||  |.:||.||..|.||.|.:||.|||||....| ....||||::|:||.:.
  Fly  3624 PESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEK 3688

  Fly  3483 DCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGA 3547
            ||.||||||.||.|.||..|.:||.|..||..:.:|||::.|||.|||.||| ..|..:..||
  Fly  3689 DCKDGSDEPATCAPRHCRAGTFQCKNTNCTPSATICDGVDDCGDRSDEQNCD-LPCPLSDFKC-- 3750

  Fly  3548 TANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVC------KKDQFQCGNNRCMPFVWVCDGDID 3606
              .||..|:.:..||||..||..|.||.   |.||      .|.:|.|.|.||:|.:|:||.|.|
  Fly  3751 --KSSGRCILDSWRCDGDADCKDGSDED---PAVCFKRTCDPKTEFSCKNGRCIPQLWMCDFDND 3810

  Fly  3607 CPDKSDEA--NCDNVSCGPNDFQC---DSGRCIPLAWRCDDDHDCPNGEDE-PASCFSSKATCDP 3665
            |.|.|||.  .|...:|.....:|   .:.||||....||...||.:..|| |.:|    ..|:|
  Fly  3811 CGDDSDEPAYMCRQRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENC----PKCNP 3871

  Fly  3666 -TYFKCNNSKCIPGRWRCDYENDCGDGSDELNC----QMRNCSESEFRCGTGKCIKHNYRCDGEI 3725
             |.|||.|::|||.:|.||:.:||||.|||...    :.|.|||||||||.||||...::||.|.
  Fly  3872 ETDFKCGNNRCIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHED 3936

  Fly  3726 HCDDNSDEINC-NITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNCT--------CHSDH 3781
            .|.|||||::| ...||...|:||: ..||...::||||.||.|.||||.|.        |....
  Fly  3937 DCGDNSDEMHCEGYQCKNGTFQCAS-GHCIASYFRCDGDRDCRDMSDEVGCPPRFPGGRYCPESR 4000

  Fly  3782 FSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHA-NAFKCRNQLCVRNSALCDGINDCGE 3845
            |.|.|..|:.....|||.|||.|||||....|:..:|.. ..|:|.|:.||....:|||:::||:
  Fly  4001 FQCNNNLCVSLSDLCDGTDDCGDGSDEDPSVCSDFNCDTLRRFQCSNERCVARYQICDGVDNCGD 4065

  Fly  3846 NEDESD-AVCAALPK-C-RHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNC-QPPVC---GFGS 3903
            ..||:: .:||:..| | .:.|:||.|..||.::..||...:|.|.|||:.| ....|   ..|.
  Fly  4066 GSDENNMTLCASKQKPCDLYTQYQCANKHCIERSQVCDFSDDCGDASDELGCHHTSSCSEANRGG 4130

  Fly  3904 CSQIC---------------------IEKKA---------------------GHYNCKCADGYHK 3926
            |.|.|                     .:||.                     |.|:|.|.:|:|.
  Fly  4131 CQQHCHNLTDGGYICTCYPGYIIAADNKKKCSDVDECLTRQHTCSHQCHNLNGTYSCSCREGFHL 4195

  Fly  3927 GPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFW 3991
            ....:..|.|...|.|||..:.||.|.:...|.|...|:    ....:|:..|  ...:..::||
  Fly  4196 TDGASGVCRAEKEDVILLFVNGQEIRGLNWHKSEEFAVI----AAEKRIEALD--YDAQQQIVFW 4254

  Fly  3992 IDSHHGKVHTMKIATPHVEGTG-VRVRRDLKELTAFNIPELDDPKSLAVDWISQRVYIID----- 4050
            .||:...:....:... ::|.. :...:||      |:.....|.::||||::..:|..:
  Fly  4255 ADSYDKTIKRSYMVNA-IDGRAKIGFAQDL------NMKGGSKPTAVAVDWLASNLYWTEMDRTG 4312

  Fly  4051 -SRHNQILATDIEGKKYISLVSTGMN-PTDIVLEPESRIMIWSTLENG--ILVASLDGSNKKSLV 4111
             ....:::....:|:...|:|:.|:. ||.|.:.|:...:.||...:.  |.|:.:|||.::.|:
  Fly  4313 SKPRGRVMVAKTDGRYRRSIVNAGLEVPTSIAVNPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLI 4377

  Fly  4112 ERDVGWPISLSMDYPTGR-LYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYIK 4175
            ...:..|..|::||.... :||.|.:...||:.|.:|..|..:.|......|..:|:||..::..
  Fly  4378 TEMIRHPAGLTIDYSQDHIIYWVDTKLNAIESMRADGSRRKAIVRGDQLRHPVSLDLFESNMFWM 4442

  Fly  4176 LYDQ-SIIKMNKFGNDNGTYLLKGY--RSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSE 4237
            ..|. .:::.:|||. ....:|..|  ..|.:.:.|..:.|.::.|||....|..   ||:|...
  Fly  4443 TRDTGELVRQDKFGR-GVQVVLHRYIVNPSGLKVYHDKRYNTSLPNPCDNSTCSH---LCLLVPG 4503

  Fly  4238 SSVGYSCKCAE------GYVMTDDGVCKAHAD----IPDYCPLQCNLGTCK------IVDHVPKC 4286
               |:.|.|.:      .:..|.:.:|.|.|:    .|..||.| |.|.||      ::     |
  Fly  4504 ---GHRCACPDASGPPPSHRSTAEVICNAAAEHPRPAPRICPCQ-NGGLCKEDAQGELL-----C 4559

  Fly  4287 ICQPQFEGELCE 4298
            .|:.||.||.||
  Fly  4560 ECRTQFVGEHCE 4571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566	13/30 (43%)
		LDLa	126..163	CDD:238060	14/101 (14%)
		EGF_CA	246..283	CDD:214542	19/36 (53%)
		Ldl_recept_b	449..487	CDD:278487	13/37 (35%)
		LY	472..513	CDD:214531	15/40 (38%)
		LY	817..852	CDD:214531	13/34 (38%)
		LDLa	1057..1092	CDD:197566	15/34 (44%)
		LDLa	1104..1134	CDD:238060	10/29 (34%)
		FXa_inhibition	1289..1317	CDD:291342	10/27 (37%)
		LY	1434..1476	CDD:214531	23/43 (53%)
		LY	1477..1521	CDD:214531	19/45 (42%)
		LY	1533..1567	CDD:214531	18/33 (55%)
		LY	1568..1611	CDD:214531	17/42 (40%)
		FXa_inhibition	1639..1676	CDD:291342	12/38 (32%)
		LY	1794..1838	CDD:214531	12/52 (23%)
		LY	2078..2112	CDD:214531	18/40 (45%)
		NHL	<2082..>2152	CDD:302697	34/75 (45%)
		NHL repeat	2082..2120	CDD:271320	19/40 (48%)
		FXa_inhibition	2269..2303	CDD:291342	17/45 (38%)
		LY	2430..2471	CDD:214531	12/42 (29%)
		LY	2475..2517	CDD:214531	16/41 (39%)
		LDLa	2630..2661	CDD:238060	11/30 (37%)
		LDLa	2671..2702	CDD:238060	16/30 (53%)
		LDLa	2727..2759	CDD:238060	13/35 (37%)
		LDLa	2773..2802	CDD:238060	15/30 (50%)
		LDLa	2810..2844	CDD:238060	16/35 (46%)
		LDLa	2848..2878	CDD:238060	14/30 (47%)
		LDLa	2887..2916	CDD:197566	13/34 (38%)
		LDLa	2938..2969	CDD:197566	11/30 (37%)
		LDLa	2989..3015	CDD:197566	12/25 (48%)
		LDLa	3030..3061	CDD:238060	15/31 (48%)
		EGF_CA	3062..>3091	CDD:214542	13/30 (43%)
		EGF_CA	3103..3141	CDD:214542	19/40 (48%)
		LY	3212..3254	CDD:214531	15/45 (33%)
		LY	3255..3297	CDD:214531	14/41 (34%)
		LY	3299..3340	CDD:214531	18/42 (43%)
		LY	3354..3389	CDD:214531	13/34 (38%)
		LDLa	3458..3490	CDD:238060	16/32 (50%)
		LDLa	3499..3533	CDD:238060	16/33 (48%)
		LDLa	3582..3616	CDD:238060	18/41 (44%)
		LDLa	3621..3652	CDD:197566	10/33 (30%)
		LDLa	3663..3697	CDD:238060	20/34 (59%)
		LDLa	3702..3736	CDD:238060	22/33 (67%)
		LDLa	3776..3808	CDD:197566	14/39 (36%)
		LDLa	3818..3849	CDD:197566	11/31 (35%)
		LDLa	3860..3894	CDD:238060	14/34 (41%)
		NHL	4029..>4158	CDD:302697	35/138 (25%)
		NHL repeat	4034..4074	CDD:271320	9/45 (20%)
		NHL repeat	4076..4115	CDD:271320	12/40 (30%)
		LY	4108..4150	CDD:214531	12/42 (29%)
		NHL repeat	4121..4158	CDD:271320	12/37 (32%)
		EGF_CA	<4386..4414	CDD:238011
		EGF_CA	4415..4450	CDD:238011
mgl	NP_001096924.2	LDLa	157..189	CDD:238060	14/31 (45%)
		LDLa	204..236	CDD:238060	3/31 (10%)
		LDLa	292..327	CDD:238060	4/34 (12%)
		LDLa	332..366	CDD:238060	11/33 (33%)
		LDLa	371..412	CDD:238060	1/40 (3%)
		vWFA	<447..488	CDD:294047	23/41 (56%)
		NHL	573..>716	CDD:302697	47/168 (28%)
		NHL repeat	573..610	CDD:271320	9/54 (17%)
		NHL repeat	616..654	CDD:271320	14/38 (37%)
		NHL repeat	657..693	CDD:271320	14/35 (40%)
		FXa_inhibition	763..805	CDD:291342	14/42 (33%)
		LY	922..964	CDD:214531	9/46 (20%)
		LY	973..1007	CDD:214531	12/33 (36%)
		Ldl_recept_a	1188..1223	CDD:278486	11/35 (31%)
		LDLa	1227..1259	CDD:197566	15/34 (44%)
		LDLa	1268..1303	CDD:238060	13/38 (34%)
		LDLa	1308..1343	CDD:238060	14/34 (41%)
		LDLa	1356..1387	CDD:238060	13/45 (29%)
		LDLa	1391..1423	CDD:197566	5/31 (16%)
		LDLa	1435..1469	CDD:197566	9/33 (27%)
		FXa_inhibition	1478..1513	CDD:291342	11/34 (32%)
		FXa_inhibition	1522..1553	CDD:291342	10/30 (33%)
		LY	1625..1665	CDD:214531	22/39 (56%)
		LY	1667..1711	CDD:214531	19/44 (43%)
		Ldl_recept_b	1690..1728	CDD:278487	20/41 (49%)
		LY	1712..1754	CDD:214531	19/44 (43%)
		LY	1986..2037	CDD:214531	12/53 (23%)
		FXa_inhibition	2151..>2179	CDD:291342	9/29 (31%)
		LY	2259..2305	CDD:214531	18/55 (33%)
		Ldl_recept_b	2326..2366	CDD:278487	14/41 (34%)
		LY	2352..2392	CDD:214531	11/41 (27%)
		NHL	2579..>2711	CDD:302697	44/144 (31%)
		NHL repeat	2593..2622	CDD:271320	10/35 (29%)
		NHL repeat	2634..2678	CDD:271320	13/43 (30%)
		LY	2671..2713	CDD:214531	16/41 (39%)
		LDLa	2867..2901	CDD:238060	19/35 (54%)
		LDLa	2906..2941	CDD:238060	13/39 (33%)
		LDLa	2950..2983	CDD:238060	15/35 (43%)
		LDLa	3034..3066	CDD:197566	14/31 (45%)
		LDLa	3080..3115	CDD:197566	13/40 (33%)
		LDLa	3128..3159	CDD:238060	11/30 (37%)
		LDLa	3170..3204	CDD:238060	15/37 (41%)
		LDLa	3210..3242	CDD:197566	13/31 (42%)
		cEGF	3269..3292	CDD:289433	10/23 (43%)
		vWFA	<3284..3324	CDD:294047	17/40 (43%)
		LY	3362..3394	CDD:214531	11/31 (35%)
		LY	3406..3448	CDD:214531	15/41 (37%)
		LY	3498..3536	CDD:214531	17/37 (46%)
		LY	3536..3578	CDD:214531	16/46 (35%)
		FXa_inhibition	3607..3659	CDD:291342	18/51 (35%)
		LDLa	3663..3696	CDD:238060	16/32 (50%)
		LDLa	3705..3739	CDD:238060	16/33 (48%)
		LDLa	3743..3775	CDD:197566	13/35 (37%)
		LDLa	3784..3817	CDD:197566	15/32 (47%)
		LDLa	3827..3861	CDD:197566	10/33 (30%)
		LDLa	3871..3901	CDD:197566	17/29 (59%)
		LDLa	3913..3947	CDD:238060	22/33 (67%)
		LDLa	3952..3986	CDD:238060	18/34 (53%)
		LDLa	3996..4027	CDD:197566	14/30 (47%)
		LDLa	4043..4071	CDD:238060	12/27 (44%)
		LDLa	4086..4117	CDD:238060	13/30 (43%)
		EGF_CA	4163..4194	CDD:214542	5/30 (17%)
		NHL	4276..>4426	CDD:302697	38/155 (25%)
		NHL repeat	4291..4336	CDD:271320	9/44 (20%)
Ldl_recept_b	4350..4390	CDD:278487	10/39 (26%)
NHL repeat	4376..4422	CDD:271320	13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461702
Domainoid	1	1.000	55	1.000	Domainoid score	I11124
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1326at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	1	1.100	-	-	P	PTHR22722
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850