DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and VLDLR

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_003374.3 Gene:VLDLR / 7436 HGNCID:12698 Length:873 Species:Homo sapiens


Alignment Length:877 Identity:298/877 - (33%)
Similarity:421/877 - (48%) Gaps:169/877 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  2622 CIAPVNT---------SCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFM 2677
            |.||..:         .|..||:.|.:|.||.|...||....|.|||||  ..|:.:.|.|:.|:
Human    16 CWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE--KNCVKKTCAESDFV 78

  Fly  2678 CQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKF 2742
            |.|.:|:|...||||:..|.|||||:|..|                                   
Human    79 CNNGQCVPSRWKCDGDPDCEDGSDESPEQC----------------------------------- 108

  Fly  2743 LCDSLKDCRDFSDEKMCAPIPCEKNDMTFVH---CG-NSTICIMPRWRCDGDPDCPDGTDELDCA 2803
               .::.||                    :|   || :||.||...|||||:.||..|.||.:|.
Human   109 ---HMRTCR--------------------IHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150

  Fly  2804 NHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDG 2868
            |   ::|.|.:|.|:||.||:.::.|:|:.||.|||||::               |.|.:     
Human   151 N---ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD---------------CAPPT----- 192

  Fly  2869 KSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCG--G 2931
                              |..|.|||.:|. |||..||||.:.|| |...||..|    |||  .
Human   193 ------------------CGAHEFQCSTSS-CIPISWVCDDDADC-SDQSDESLE----QCGRQP 233

  Fly  2932 VAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSL---MHQCQD 2993
            |.| ..||.....|.||.||...:.||||.||..|.||.          :||..:.   ..:|:|
Human   234 VIH-TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV----------NCPSRTCRPDQFECED 287

  Fly  2994 GLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDE 3058
            |.||..::.|:|..||.|||||.:  |.:...|.|...|:|::|.||....:|::..||.|:|||
Human   288 GSCIHGSRQCNGIRDCVDGSDEVN--CKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350

  Fly  3059 EL--CNVNECLIPD-ICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINT 3120
            .|  |::||||:.: .|.|.|:|.|:||:|.|..|::::.:.  .|.|||||.....|||.|||.
Human   351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK--TCGDIDECQNPGICSQICINL 413

  Fly  3121 YGSYKCLCAKGYALVDHHT--CKATSNVSMELIFSNRYYIRQVDMTGNGSI-LINELSNAVALDY 3182
            .|.|||.|::||.: |..|  |||... ...|||:||..||::.:.....| |:.:|.|.||||.
Human   414 KGGYKCECSRGYQM-DLATGVCKAVGK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDA 476

  Fly  3183 DWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLK---NPDGLAVDWVAKNLYWCDKGLDTI 3244
            |..:|.|:|:|::...........|..:    |..|:.   ||..:|||||.|.:||.|....||
Human   477 DIAAQKLFWADLSQKAIFSASIDDKVGR----HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTI 537

  Fly  3245 EVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWP 3309
            .|:.|||..||.|.|..||||..||:.|....::|||||:...|.||||:|.:.:.::...:.||
Human   538 SVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602

  Fly  3310 NALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWE 3374
            |.:|:.....:|:|.|::...:|..||:|...|::|    ..|..|.|..|:.::|..:||.|.|
Human   603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVL----KSLEFLAHPLALTIFEDRVYWIDGE 663

  Fly  3375 TKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLA----ANCSTLCVLSPE-- 3433
            .:::...:.|.|....||:..::...|:.|:|  ...||...|.|..    ..|..||:.:|:  
Human   664 NEAVYGANKFTGSELATLVNNLNDAQDIIVYH--ELVQPSGKNWCEEDMENGGCEYLCLPAPQIN 726

  Fly  3434 --EPYYKCMCPTNFILADDGRTCRANCTAAHF 3463
              .|.|.|.||:.:.:.::||.|::..|...:
Human   727 DHSPKYTCSCPSGYNVEENGRDCQSTATTVTY 758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060 14/30 (47%)
LDLa 2671..2702 CDD:238060 15/30 (50%)
LDLa 2727..2759 CDD:238060 2/31 (6%)
LDLa 2773..2802 CDD:238060 17/32 (53%)
LDLa 2810..2844 CDD:238060 17/33 (52%)
LDLa 2848..2878 CDD:238060 2/29 (7%)
LDLa 2887..2916 CDD:197566 15/28 (54%)
LDLa 2938..2969 CDD:197566 14/30 (47%)
LDLa 2989..3015 CDD:197566 12/25 (48%)
LDLa 3030..3061 CDD:238060 13/32 (41%)
EGF_CA 3062..>3091 CDD:214542 13/29 (45%)
EGF_CA 3103..3141 CDD:214542 20/39 (51%)
LY 3212..3254 CDD:214531 19/44 (43%)
LY 3255..3297 CDD:214531 21/41 (51%)
LY 3299..3340 CDD:214531 11/40 (28%)
LY 3354..3389 CDD:214531 10/34 (29%)
LDLa 3458..3490 CDD:238060 1/6 (17%)
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
VLDLRNP_003374.3 LDLa 33..67 CDD:238060 16/35 (46%)
LDLa 71..103 CDD:197566 15/31 (48%)
Ldl_recept_a 111..149 CDD:278486 19/57 (33%)
LDLa 154..188 CDD:238060 17/48 (35%)
Ldl_recept_a 192..224 CDD:278486 16/56 (29%)
Ldl_recept_a 237..273 CDD:278486 16/45 (36%)
Ldl_recept_a 276..312 CDD:278486 14/37 (38%)
Ldl_recept_a 320..350 CDD:278486 11/29 (38%)
FXa_inhibition 360..394 CDD:291342 12/35 (34%)
EGF_CA 396..426 CDD:214542 17/29 (59%)
Ldl_recept_b 481..521 CDD:278487 10/43 (23%)
LY 505..547 CDD:214531 19/41 (46%)
Ldl_recept_b 568..608 CDD:278487 15/39 (38%)
LY 592..634 CDD:214531 11/41 (27%)
Ldl_recept_b 655..694 CDD:278487 9/38 (24%)
FXa_inhibition 706..749 CDD:291342 12/42 (29%)
Mucin <751..813 CDD:250634 1/8 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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