DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and SORL1

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_003096.2 Gene:SORL1 / 6653 HGNCID:11185 Length:2214 Species:Homo sapiens


Alignment Length: Identity:/ - (0%)
Similarity:/ - (0%) Gaps:/ - (0%)


- Green bases have known domain annotations that are detailed below.


Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
SORL1NP_003096.2 Cell attachment site. /evidence=ECO:0000255 63..65
VPS10 124..753 CDD:214740
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452
BNR 4 521..532
BNR 5 562..573
LY 780..821 CDD:214531
LDL-receptor class B 1 800..843
LY 824..866 CDD:214531
LDL-receptor class B 2 844..887
LY 868..910 CDD:214531
LDL-receptor class B 3 888..932
Ldl_recept_b 890..929 CDD:278487
LY 913..953 CDD:214531
LDL-receptor class B 4 933..970
LDL-receptor class B 5 971..1013
LDLa 1078..1112 CDD:238060
LDLa 1120..1153 CDD:238060
Ldl_recept_a 1157..1192 CDD:278486
LDLa 1198..1230 CDD:197566
LDLa 1240..1271 CDD:238060
LDLa 1281..1308 CDD:197566
LDLa 1325..1359 CDD:238060
LDLa 1373..1403 CDD:238060
LDLa 1419..1453 CDD:238060
LDLa 1471..1506 CDD:238060
LDLa 1513..1546 CDD:197566
FN3 1557..>1628 CDD:238020
FN3 1651..1742 CDD:238020
FN3 1749..1829 CDD:214495
FN3 1934..2021 CDD:238020
FN3 2025..2112 CDD:238020
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305|PubMed:16531402 2161..2164
Endocytosis signal. /evidence=ECO:0000255 2172..2177
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269|PubMed:17646382 2190..2214
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269|PubMed:11821067 2201..2214
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269|PubMed:20015111 2208..2212
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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