| Sequence 1: | NP_001260800.2 | Gene: | LRP1 / 35799 | FlyBaseID: | FBgn0053087 | Length: | 4752 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_021325253.1 | Gene: | lrp1ba / 565136 | ZFINID: | ZDB-GENE-050208-608 | Length: | 4654 | Species: | Danio rerio |
| Alignment Length: | 5054 | Identity: | 1683/5054 - (33%) |
|---|---|---|---|
| Similarity: | 2431/5054 - (48%) | Gaps: | 822/5054 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 80 LTAGGGP--CPASYFTCNDGF-CIPMRWKCDSKADCPDMSDEGSECAP---------KCNEGQFR 132
Fly 133 CGVSRHCIPNNWLCDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCD 197
Fly 198 NDELQCDKQNAACAALNCSFNCKLTPQGARCYCPKD-QVPESSNSTRCVDYDECSEPGTCDQVCR 261
Fly 262 NTPGSYECSCVSGYAKTKGNR-CRAINVPPTEPTTLIFLSRDGVQSVGTNGTEVIGPPGAKDNDK 325
Fly 326 VTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPELQMRCQRV---------DDARV 381
Fly 382 NWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVILQ-QVDPLSSLDLD 445
Fly 446 PTKGFMFYTDW--TPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDY 508
Fly 509 EGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLAAWMD-------TAIVALDKFSLKTHILQSNV 566
Fly 567 SRGANLRIFHRQKQPEV-AHPC----RDNNAGCNQICVPQWTKGFASAKCMCTAGYKLHNQ-TTC 625
Fly 626 LLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFY 690
Fly 691 VVADSGASPFGNGEPSCSIRSQSLNGSV-SRLLAQGLKRVHAVAFDWINDHLYWTS---HKKMQV 751
Fly 752 APLRNLS---KVLTFNTDCDAMSLELDPTTGLLYWSQWESQ---SCEAGIYSSWMDGTHKELLAK 810
Fly 811 GTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQF-HPYSIVQNNGLIY 874
Fly 875 WADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAA--DLRIFDIASQ----PLPQTPSACAQSK 933
Fly 934 CPGMCLNTPKGAICRCPDGFTLNGTGSHCIPQLAPSPIRPNCTSGYMCRSTRQCLDTKDMCDGFE 998
Fly 999 DCEDGIDESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCSTIPYCSDGTDQAN--CHQNTCNS 1060
Fly 1061 NEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCP--EFDCNNGRCRQFADVCDGID 1123
Fly 1124 NCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDE-ANCNQTKSDNHPVTEWKE 1187
Fly 1188 LGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRL-CGF 1251
Fly 1252 SKQCVTVDQLCDGKNDCEDTTDE-----------GFLCA---------DKLC-------DRGHE- 1288
Fly 1289 ------------CSHRCHNTP-EGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGY 1340
Fly 1341 DCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNE 1405
Fly 1406 SNVEIYWTDVIDDKIYRGHL-VGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVA 1469
Fly 1470 KLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGW 1534
Fly 1535 PNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTS 1599
Fly 1600 VIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGEN--NGGCSHLCLLSGRGTFKCEC 1662
Fly 1663 PHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESR 1727
Fly 1728 IFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYF-SSGQIKCNILASNLKGEF 1791
Fly 1792 ASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFD 1856
Fly 1857 SQRLYYA-----------YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSV 1910
Fly 1911 IMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCA 1975
Fly 1976 LGYDVEPNNPTGCVPRAEFIFYSIDVLQGVE--MIDPSEQFDTPSPALVPISRVSSASFIDYLAN 2038
Fly 2039 TDTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLG---GIAIDWVAGNIYWSDTKRN 2100
Fly 2101 IIEVARLDGSHRYVVVS-NLEKPTALAVDPLQGLLFYV---TQQHIGRVGLDGSQPFVLVNQ--T 2159
Fly 2160 RANWAVGSLVLDIEATKVYWCERYPDALMKVDYD-GNLREQLLNESLNNPVALAKMGDYLYWAEN 2223
Fly 2224 KYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTS-A 2287
Fly 2288 VCACAHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNY 2352
Fly 2353 EEQL-----VYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSV 2412
Fly 2413 ELRHLSEHADQNQVHV---KKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGT 2474
Fly 2475 EVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLF 2539
Fly 2540 WTDWVLHAVVRANKYTGTDVLFLREHVT-RPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKS 2603
Fly 2604 GQATCHCTQGVLAPDGRRCIAPVNTSCGL-SQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCI 2667
Fly 2668 FRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRC 2732
Fly 2733 GSGECIPRKFLCDSLKDCRDFSDEKMCAPIPC---------EKNDMTFVHCGNSTICIMPRWRCD 2788
Fly 2789 GDPDCPDGTDELDC---ANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRH 2850
Fly 2851 NQFACDKT-CIPASWQCDGKSDCEDGSDEGPQ-CPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDC 2913
Fly 2914 PSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQ 2978
Fly 2979 PHSCPGGSLMHQCQDGLCIFKNQ-TCDGKPDCGDGSDE--TSSLCAHTRG-CNGTDDFRCKNGAC 3039
Fly 3040 IHADLLCDRRNDCADFSDEELCNVNECLIPDI--CEHECEDKVVGYQCHCRPGYKVLPKSPHLCT 3102
Fly 3103 DIDECDEQQPCSQTCINTYGSYKCLCAKGY--ALVDHHTCKATSNVSMELIFSNRYYIRQVDMTG 3165
Fly 3166 NGSILINE-LSNAVALDYDWDSQCLYWSDVTSTVG-TIKRYCPKENKTQTLHQAMLKNPDGLAVD 3228
Fly 3229 WVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGM 3293
Fly 3294 DGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHI 3358
Fly 3359 FAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN 3423
Fly 3424 --CSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGD 3486
Fly 3487 GSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANS 3551
Fly 3552 SAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNN-RCMPFVWVCDGDIDCPDKSDEAN 3615
Fly 3616 CDNVSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDEP----------------ASCFSSKATCD 3664
Fly 3665 PTY-------------------FKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRN--------- 3701
Fly 3702 CSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDC 3766
Fly 3767 PDGSDEVNC-----TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHAN-AFKC 3825
Fly 3826 RN-QLCVRNSALCDGINDCGENEDESDAVCAALPK---CRHDQFQCENDDCISKAFRCDGQYNCV 3886
Fly 3887 DGSDEMNC----------QPPVCG-------------------------------------FGSC 3904
Fly 3905 SQICIEKKAGHYNCKCADGYHKGPEKNATCLASGP-DQILLLASEQEFR-FILPAKQ-EGTTVVG 3966
Fly 3967 FFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKEL------TA 4025
Fly 4026 FNIPELDDPKSLAVDWISQRVYIIDSRHNQI-----------------------------LATDI 4061
Fly 4062 EGKKYISLVSTGMNPTDIVLEPESRIMIWSTL--ENGILVASLDGSNKKSLVERDVGWPISLSMD 4124
Fly 4125 YPTGRLYWADYRKGTIETCRLNGKDRNVV--RRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKF 4187
Fly 4188 GNDNGTYLLKGY-RSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEGYV 4251
Fly 4252 MTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAP 4316
Fly 4317 ALPGSQEPPPLKCTCT-AGWSGARCETSMPACQSRCHNGGSCLISETEGMKCSCPKMFTGEQCE- 4379
Fly 4380 -HCRNLTCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSG 4443
Fly 4444 YFGEHCESNSCRDFCRNGGTCS-ERGGRLSCTCPPRYIGESCESDLC------------KTSSPP 4495
Fly 4496 HFCDNTKVPTRDPCTLM--ICQNAGTCHIIK--GVALCNCTDQWNGDLCTLPVTDD--NPCARYC 4554
Fly 4555 ANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLCENNRVVPCLSDSA 4619
Fly 4620 DALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKHRIA-----QPFSHARLTDNVEI 4679
Fly 4680 -MLTNAMYRGDADE--------APTFASEDDKG-------------------------------- 4703
Fly 4704 -----NFANPVYESMY----------------ADAIPEPVSTEITHSTA 4731 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRP1 | NP_001260800.2 | LDLa | 87..118 | CDD:197566 | 14/31 (45%) |
| LDLa | 126..163 | CDD:238060 | 13/36 (36%) | ||
| EGF_CA | 246..283 | CDD:214542 | 18/37 (49%) | ||
| Ldl_recept_b | 449..487 | CDD:459654 | 14/39 (36%) | ||
| LY | 472..513 | CDD:214531 | 18/40 (45%) | ||
| LY | 817..852 | CDD:214531 | 13/34 (38%) | ||
| LDLa | 1057..1092 | CDD:197566 | 15/34 (44%) | ||
| LDLa | 1104..1134 | CDD:238060 | 12/29 (41%) | ||
| LDLa | 1191..1226 | CDD:238060 | 16/34 (47%) | ||
| FXa_inhibition | 1289..1317 | CDD:464251 | 11/28 (39%) | ||
| LY | 1434..1476 | CDD:214531 | 30/41 (73%) | ||
| LY | 1477..1521 | CDD:214531 | 31/43 (72%) | ||
| LY | 1533..1567 | CDD:214531 | 19/33 (58%) | ||
| LY | 1568..1611 | CDD:214531 | 24/42 (57%) | ||
| FXa_inhibition | 1639..1676 | CDD:464251 | 19/38 (50%) | ||
| LY | 1751..1789 | CDD:214531 | 12/38 (32%) | ||
| LY | 1794..1838 | CDD:214531 | 14/43 (33%) | ||
| LY | 2078..2112 | CDD:214531 | 21/36 (58%) | ||
| NHL | <2082..>2152 | CDD:302697 | 38/73 (52%) | ||
| NHL repeat | 2082..2120 | CDD:271320 | 23/38 (61%) | ||
| FXa_inhibition | 2269..2303 | CDD:464251 | 18/34 (53%) | ||
| LY | 2430..2471 | CDD:214531 | 18/40 (45%) | ||
| LY | 2475..2517 | CDD:214531 | 19/41 (46%) | ||
| LDLa | 2630..2661 | CDD:238060 | 15/31 (48%) | ||
| LDLa | 2671..2702 | CDD:238060 | 11/30 (37%) | ||
| LDLa | 2727..2759 | CDD:238060 | 14/31 (45%) | ||
| LDLa | 2773..2802 | CDD:238060 | 12/28 (43%) | ||
| LDLa | 2810..2844 | CDD:238060 | 20/33 (61%) | ||
| LDLa | 2848..2878 | CDD:238060 | 17/30 (57%) | ||
| LDLa | 2887..2916 | CDD:197566 | 15/28 (54%) | ||
| LDLa | 2938..2969 | CDD:197566 | 10/30 (33%) | ||
| LDLa | 2989..3015 | CDD:197566 | 13/26 (50%) | ||
| LDLa | 3030..3061 | CDD:238060 | 12/30 (40%) | ||
| EGF_CA | 3062..>3091 | CDD:214542 | 14/30 (47%) | ||
| EGF_CA | 3103..3141 | CDD:214542 | 23/39 (59%) | ||
| LY | 3212..3254 | CDD:214531 | 18/41 (44%) | ||
| Ldl_recept_b | 3275..3314 | CDD:459654 | 17/38 (45%) | ||
| LY | 3299..3340 | CDD:214531 | 13/40 (33%) | ||
| LY | 3354..3389 | CDD:214531 | 8/34 (24%) | ||
| LDLa | 3458..3490 | CDD:238060 | 21/31 (68%) | ||
| LDLa | 3499..3533 | CDD:238060 | 17/33 (52%) | ||
| LDLa | 3582..3616 | CDD:238060 | 18/34 (53%) | ||
| LDLa | 3621..3652 | CDD:197566 | 14/30 (47%) | ||
| LDLa | 3663..3697 | CDD:238060 | 15/52 (29%) | ||
| LDLa | 3702..3736 | CDD:238060 | 14/33 (42%) | ||
| LDLa | 3776..3808 | CDD:197566 | 15/31 (48%) | ||
| LDLa | 3818..3849 | CDD:197566 | 15/32 (47%) | ||
| LDLa | 3860..3894 | CDD:238060 | 14/33 (42%) | ||
| YncE | 3935..4148 | CDD:442618 | 61/252 (24%) | ||
| LY | 4108..4150 | CDD:214531 | 15/41 (37%) | ||
| EGF_CA | <4386..4414 | CDD:238011 | 11/27 (41%) | ||
| EGF_CA | 4415..4450 | CDD:238011 | 15/34 (44%) | ||
| lrp1ba | XP_021325253.1 | LDLa | 30..62 | CDD:197566 | 14/31 (45%) |
| LDLa | 74..107 | CDD:197566 | 11/34 (32%) | ||
| FXa_inhibition | 161..191 | CDD:464251 | 14/29 (48%) | ||
| LY | 276..309 | CDD:214531 | 9/41 (22%) | ||
| LY | 317..359 | CDD:214531 | 12/41 (29%) | ||
| LY | 362..402 | CDD:214531 | 18/39 (46%) | ||
| FXa_inhibition | 487..519 | CDD:464251 | 9/33 (27%) | ||
| LY | 553..593 | CDD:214531 | 9/50 (18%) | ||
| LY | 594..633 | CDD:214531 | 13/38 (34%) | ||
| LY | 640..689 | CDD:214531 | 13/48 (27%) | ||
| LY | 690..732 | CDD:214531 | 15/45 (33%) | ||
| FXa_inhibition | 801..838 | CDD:464251 | 11/39 (28%) | ||
| LDLa | 891..924 | CDD:238060 | 10/33 (30%) | ||
| LDLa | 974..1007 | CDD:238060 | 13/32 (41%) | ||
| LDLa | 1011..1042 | CDD:197566 | 12/30 (40%) | ||
| LDLa | 1057..1092 | CDD:238060 | 16/34 (47%) | ||
| LDLa | 1104..1135 | CDD:238060 | 14/30 (47%) | ||
| LDLa | 1140..1173 | CDD:197566 | 5/32 (16%) | ||
| FXa_inhibition | 1180..1216 | CDD:464251 | 11/35 (31%) | ||
| LY | 1284..1322 | CDD:214531 | 20/40 (50%) | ||
| Vgb | 1306..>1498 | CDD:443399 | 115/192 (60%) | ||
| LY | 1331..1370 | CDD:214531 | 28/38 (74%) | ||
| LY | 1375..1418 | CDD:214531 | 31/42 (74%) | ||
| Ldl_recept_b | 1622..1662 | CDD:459654 | 9/39 (23%) | ||
| LY | 1645..1687 | CDD:214531 | 12/41 (29%) | ||
| LY | 1689..1728 | CDD:214531 | 13/44 (30%) | ||
| LY | <1739..1770 | CDD:214531 | 7/30 (23%) | ||
| FXa_inhibition | 1842..1878 | CDD:464251 | 15/38 (39%) | ||
| NHL | 1923..>2095 | CDD:302697 | 70/185 (38%) | ||
| NHL repeat | 1923..1956 | CDD:271320 | 16/42 (38%) | ||
| NHL repeat | 1961..1996 | CDD:271320 | 22/34 (65%) | ||
| NHL repeat | 2002..2040 | CDD:271320 | 16/37 (43%) | ||
| NHL repeat | 2043..2084 | CDD:271320 | 10/44 (23%) | ||
| FXa_inhibition | 2151..2186 | CDD:464251 | 18/34 (53%) | ||
| LY | 2265..2305 | CDD:214531 | 18/46 (39%) | ||
| Ldl_recept_b | 2334..2376 | CDD:459654 | 20/41 (49%) | ||
| LY | 2359..2401 | CDD:214531 | 19/41 (46%) | ||
| FXa_inhibition | 2472..2506 | CDD:464251 | 11/33 (33%) | ||
| LDLa | 2518..2547 | CDD:238060 | 15/28 (54%) | ||
| LDLa | 2556..2590 | CDD:238060 | 13/35 (37%) | ||
| LDLa | 2595..2629 | CDD:238060 | 14/33 (42%) | ||
| LDLa | <2652..2681 | CDD:412164 | 12/28 (43%) | ||
| LDLa | 2689..2723 | CDD:238060 | 20/33 (61%) | ||
| LDLa | 2727..2758 | CDD:238060 | 17/30 (57%) | ||
| LDLa | 2768..2801 | CDD:238060 | 17/33 (52%) | ||
| LDLa | 2811..2843 | CDD:197566 | 10/31 (32%) | ||
| LDLa | 2852..2884 | CDD:197566 | 14/33 (42%) | ||
| LDLa | 2898..2932 | CDD:238060 | 16/34 (47%) | ||
| cEGF | 2957..2978 | CDD:463661 | 7/21 (33%) | ||
| EGF_CA | 2975..3005 | CDD:214542 | 21/29 (72%) | ||
| LY | 3042..3086 | CDD:214531 | 13/43 (30%) | ||
| LY | 3088..3125 | CDD:214531 | 17/38 (45%) | ||
| Ldl_recept_b | 3149..3190 | CDD:459654 | 19/40 (48%) | ||
| LY | 3173..3213 | CDD:214531 | 13/47 (28%) | ||
| FXa_inhibition | 3284..3320 | CDD:464251 | 19/36 (53%) | ||
| LDLa | 3324..3355 | CDD:197566 | 21/31 (68%) | ||
| LDLa | 3364..3398 | CDD:238060 | 17/33 (52%) | ||
| LDLa | 3403..3438 | CDD:238060 | 13/38 (34%) | ||
| LDLa | 3443..3478 | CDD:238060 | 18/34 (53%) | ||
| LDLa | 3483..3517 | CDD:238060 | 16/33 (48%) | ||
| LDLa | 3522..3556 | CDD:238060 | 5/33 (15%) | ||
| LDLa | 3560..3594 | CDD:238060 | 13/33 (39%) | ||
| LDLa | 3608..3642 | CDD:238060 | 14/33 (42%) | ||
| LDLa | 3646..3681 | CDD:238060 | 15/34 (44%) | ||
| LDLa | 3688..3720 | CDD:238060 | 16/31 (52%) | ||
| LDLa | 3729..3765 | CDD:238060 | 17/35 (49%) | ||
| LDLa | 3775..3809 | CDD:238060 | 14/33 (42%) | ||
| Ldl_recept_b | 4051..4092 | CDD:459654 | 10/40 (25%) | ||
| LY | 4075..4116 | CDD:214531 | 15/40 (38%) |