Protein Alignment LRP1 and lrp1aa

DIOPT Version :10

• Sequence 1: NP_001260800.2
• Gene: LRP1 / 35799
• FlyBaseID: FBgn0053087
• Length: 4752
• Species: Drosophila melanogaster
• Sequence 2: XP_073772278.1
• Gene: lrp1aa / 563149
• ZFINID: ZDB-GENE-030131-7889
• Length: 4578
• Species: Danio rerio
• Alignment Length: 4928
• Identity: 1789/4928 - (36%)
• Similarity: 2545/4928 - (51%)
• Gaps: 695/4928 - (14%)

  Fly   123 APK-CNEGQFRCGVSRHCIPNNWLCDGEFDCGKGDISDELN--CPNGDTPKCRAFEGQCRNGD-C 183
            ||| |:..||.|.....||...|.||||.||..|  |||..  ||:....:|...|.||...| |
Zfish    34 APKTCSPKQFVCRDQVTCISKGWRCDGEKDCPDG--SDEAPDVCPHNRVSRCPPNEHQCLGSDLC 96

  Fly   184 LELSRFCDGRWDCDN--DE-LQCDKQNAACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCV 245
            :.:|:.|:|..||.:  || ..|.:....|....|...|.:|..|..|:| |.....|.:...|.
Zfish    97 IHMSKLCNGVPDCTDGGDEGPHCRELAHNCTLSGCQDECGVTRSGPVCFC-KSGYEISQDGKTCK 160

  Fly   246 DYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNR-CRAINVPPTEPTTLIFLSRDGVQSVGT 309
            |:|||:..|||.|.|.||.|||.||||.||.....|| |:|.|||......|:..:...:|....
Zfish   161 DFDECTVYGTCSQTCTNTDGSYSCSCVEGYLVQPDNRSCKAKNVPVDRLPVLLIANSQNIQITSL 225

  Fly   310 NGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPEL----- 369
            :|:   ..|......|.|.                    |.:..:...|:|     |..:
Zfish   226 SGS---SSPSLHITTKQTT--------------------AMDFLYTQETIC-----WINVGDSPA 262

  Fly   370 --QMRCQRV-------DDARVNWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNA 425
              .::|.::       ::..:|.:|..       ....::.:|||:||:|.|.:.|..:::|...
Zfish   263 GTHLKCAKIAGLKSFSEERTINISLSL-------HHVEQMAIDWLTGNFYFVDDVDDRIFVCDKD 320

  Fly   426 MTYCRVILQQ--VDPLSSLDLDPTKGFMFYTDW--TPSLSRSLLDGSNRTVLVTDQVYHPSSVTL 486
            ...|..:|.|  .:| ..:.||||.|.:|:||:  .|.:.|..:||.|||.||..::..|..:||
Zfish   321 GATCVTLLDQELYNP-KGIALDPTMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITL 384

  Fly   487 DLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLA----AWMD- 546
            ||.|.||||.|.|.|.:..|||||:||.|:.:.|    .::.::.:.||||.:|..    |.|.
Zfish   385 DLVNRLVYWADAYLDYIEVVDYEGKNRHTIIQGL----LIEHLYGLTVFENYLYATNSDNANMQP 445

  Fly   547 -TAIVALDKFSLKTHILQSNVSRGANLRIFHRQKQPEV-AHPCRDNN----AGCNQICVPQWTKG 605
             |:::.:::|:...:.:.:.|.:|..|.::|:::||.| :|.|..:.    .||:.||:  ....
Zfish   446 KTSVIRVNRFNSSDYQVVTRVDKGGALHVYHQRRQPPVRSHACEPDQFGKAGGCSDICL--LGNS 508

  Fly   606 FASAKCMCTAGYKLHNQ-TTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVP 669
            ..|..|.|.:|:.|.|. .:|.....:.||||.......|.|:.::.:         .|.:.|:|
Zfish   509 HKSRTCRCRSGFSLGNDGKSCKKPEHELFLVYGKGRPGVIRGMDINPK---------VQDEYMIP 564

  Fly   670 VYNVSKTLAIDVNVRGKAVFYVVADSGASPFGNGEPSCSIRSQSLNGSV-SRLLAQGLKRVHAVA 733
            :.|:....|:|.:.:...:::  ||:         .|..|..|.::|:. ..:|.:|:..|..:|
Zfish   565 IENLMNPRALDFHAQSNFIYF--ADA---------TSYLIGRQKIDGTERDIILKEGIHTVEGIA 618

  Fly   734 FDWINDHLYWTS---HKKMQVAPLRNLS---KVLTFNTDCDAMSLELDPTTGLLYWSQWE---SQ 789
            .||:.::||||.   .|.:.||.|...|   |.|.........::.:||..|.:||:.||   .:
Zfish   619 VDWMANNLYWTDDGPKKTISVARLEKASQTRKTLIEGKMTHPRAIVVDPRHGWMYWTDWEEDPKE 683

  Fly   790 SCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREV 854
            |....|..:|||||::.:|   .:|..:.||..|.:|.....|||.|.....||::.|:.|.|:.
Zfish   684 SKRGKIERAWMDGTNRNVL---LTSKTVLWPNGLSLDIPQGILYWVDAYYDRIEMVYLNTTARKT 745

  Fly   855 LFKSDQF-HPYSIVQNNGLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAA--DLRIFD 916
            ::...:. |.:.:......::|.:.::.:|.:...:        :.||.|.|..|..  ::|::|
Zfish   746 VYDGQELNHAFGLCHYKHFLFWNEYRSGSIYKLDQN--------TKTVTLLRNERPPIFEIRMYD 802

  Fly   917 IASQPLPQTPSACAQSK--CPGMCLNTPKGAICRCPDGFTL---NGTGSHCIPQLAPSPIRPNCT 976
             |.|.|..  :||..:.  |..:||.||.|..|.|.:...|   :.|.....|...|.   |.|.
Zfish   803 -AQQQLGS--NACRSNNGGCSSLCLATPTGRSCACAEDQLLDPADNTSCKANPSYIPP---PQCQ 861

  Fly   977 SG-YMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCS 1039
            .| :.|::.| |:..:..|||..||.|..||:::   .|:.:|| ....|.| |.||.....||.
Zfish   862 PGEFACKNNR-CIQERWKCDGDNDCLDNSDETAE---LCHQHTC-PADRFKCQNNRCIPMRWLCD 921

  Fly  1040 TIPYCSDGTDQAN--CHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKC 1102
            ....|.:..|::|  |...||..|:::| .|||||.::|..|...|||  |.|||.|...:.:..
Zfish   922 GDNDCGNDEDESNTTCSARTCPPNQYSC-DSGRCIPISWTCDLDDDCG--DRSDEPSTCAYPTCF 983

  Fly  1103 P--EFDCNNGRCRQFADVCDG----------------IDN-CGNNADEMECEQECEHGEKYCRPI 1148
            |  :|.||||||......||.                .|| ||:|:||..|...|...:..|...
Zfish   984 PLTQFTCNNGRCININWRCDNEKDCGDSSDEFNCPNPTDNDCGDNSDEAGCSHSCSSAQFKCNSG 1048

  Fly  1149 GCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDG 1213
            .|..:...|||.:||.|:|||.:.|.|.....|.      |.|...||.|.....|||...||||
Zfish  1049 RCIPDYWTCDGDNDCGDYSDETHANCTNQATRPP------GGCHTDEFQCRMDGLCIPLRWRCDG 1107

  Fly  1214 ISHCFDKTDEFNC---THI-----------------------------NTTRFDMNETVICEHPD 1246
            .:.|.|.:||.||   ||:                             :.:..|..|.::|:...
Zfish  1108 DTDCMDLSDEKNCEGVTHMCDPAVKFGCRDSARCISKAWVCDGDSDCEDNSDEDNCEALVCKLSH 1172

  Fly  1247 RLC-GFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCD----RGHECSHRCHNTP-EGYICSCP 1305
            .:| ..|..|:..::|||||:||.|.:||      ||||    ....|||.|...| ||.:||||
Zfish  1173 HVCANDSNICLPAEKLCDGKDDCPDGSDE------KLCDLCSLENGGCSHNCTVAPGEGVLCSCP 1231

  Fly  1306 DHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFT 1370
            ..:.|..|.|.|.:|..|.....|||.||.......|.|.:|:.|..|..:|:||.|.:|::||:
Zfish  1232 LGMELGTNNKTCQIQGFCAKHLKCSQRCEQDKFNVKCSCYEGWALEPDMESCRSTDPFKPFIIFS 1296

  Fly  1371 NRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLV--GESLRNV 1433
            ||.:|:.|:|...........|||.|||||..|..|   :|||||::||||||.|.  |.:|.:.
Zfish  1297 NRHEIRRIDLHKGEFSVLVPGLRNTIALDFHLNESS---LYWTDVVEDKIYRGKLSENGAALTSF 1358

  Fly  1434 EAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGL 1498
            :.||..||:|.|||||||:..|:||::|||||||||||:|:.|.||:||::|.|||||||||||:
Zfish  1359 DVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTMRTTLLAGDVEHPRAIALDPREGI 1423

  Fly  1499 LFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYD 1563
            |||||||.:.||||.|||||.|||.|..... |.|||||||:||.::|:.|:||:||:|.|..||
Zfish  1424 LFWTDWDASMPRIEAASMSGHGRRTIHKETG-SGGWPNGLTVDYLERRILWIDARSDAIYSAKYD 1487

  Fly  1564 GSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLH 1628
            ||....|||..|.||||||::::...||||||||.::.:||||.|::|.|:|||.:|||.:||.|
Zfish  1488 GSGLIEVLRGHEYLSHPFAVTMYGGEVYWTDWRTNTLAKANKWTGNNVTVVQRTNTQPFDLQVYH 1552

  Fly  1629 SSRQPWDRNPCGENN--GGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEI 1691
            .||||...|||....  |.||||||::...||.|.|||:|||...| ..|..:.|.||:....||
Zfish  1553 PSRQPQAPNPCAARGGLGPCSHLCLINYNQTFSCACPHLMRLREDN-HTCYESRQFLLYARQIEI 1616

  Fly  1692 RGIDLHQPNHH-----TIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPI 1751
            ||:|:|.|.::     |:|.|..      ...:|:...|.||:|||::...|..|.|:...||.:
Zfish  1617 RGVDIHNPYYNYIISFTVPDIDN------VTVVDYDALERRIYWSDVRTQTIKRAFINGTGIETV 1675

  Fly  1752 INTNIEKPYGFAVDWIARNMYFSS--GQIKCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKM 1814
            ::.:|...:|.||||::||::::|  |. |..|..:.|.|.|.:.:.:.|:....:||.|..||:
Zfish  1676 VSADIPNAHGLAVDWVSRNLFWTSYDGN-KKQINVARLDGSFKNAVIQGLDKPHCLVLHPVLGKL 1739

  Fly  1815 YWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYA-----------YDNSG 1868
            ||    :||  ..:..:|.||:::::|:.::.....|::|||::.||:.           .|.||
Zfish  1740 YW----TDG--DNISMANTDGTNQTMIFTNQKTPVGLSIDFDAEHLYWVSSGNSTINRCKLDGSG 1798

  Fly  1869 IAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQ 1933
            :...|..:.:..|.         |:|.:....|::.:.....|..|:|....|...||.:|..:.
Zfish  1799 LEVLDSVKGKLNKA---------SALAIMGDKLWWADQGTDQIGTCDKSDGGNWKVLRNSTSGMI 1854

  Fly  1934 SMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYS 1998
            .||::....|||||.|::  ..|.|.||||.||.....|.|..||.:. :....|.....|:.||
Zfish  1855 HMKIYNETVQTGSNLCSK--NNGDCSQLCLPTSQSSRSCMCTAGYSLR-SGQQSCEGVGSFLLYS 1916

  Fly  1999 I-DVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQR 2062
            : :.::|:. :||:::.|    ||||:|..|.|..||:.|:.||:||.|..|.:|||.|||.|.|
Zfish  1917 VHEGIRGIP-LDPADKSD----ALVPVSGTSLAVGIDFHADNDTIYWVDMGLSTISRAKRDQTWR 1976

  Fly  2063 ETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVS-NLEKPTALA 2126
            |.|:  .|.:|..:     |||:||:||||||:|...::||||||:||.||||:| .|:||.|:.
Zfish  1977 EDII--TNGIGRVE-----GIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAIT 2034

  Fly  2127 VDPLQGLLFYV---TQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALM 2188
            |.|.:|.||:.   ....|.|..||||...|||| ...:|..| :.:|.:...:|||:...|.:.
Zfish  2035 VHPERGYLFWTEWGQYPRIERSRLDGSGRAVLVN-VSISWPNG-ISIDYQDGLLYWCDARTDKIE 2097

  Fly  2189 KVDYD-GNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDA- 2251
            :::.: |..||.:|:.:..:..:::...:|:||::..:..|.|:.....|.::| |.|:|....
Zfish  2098 RINLETGENREVVLSSNNMDMFSVSVFENYIYWSDRTHANGSIKRGSKDNSTES-VSLRTGIGVQ 2161

  Fly  2252 IRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGT-SAVCACAHSRLASDGYSCEPYENFLLFSYR 2315
            ::|:|::::..|:|:|.|..:||.|:||||:.|. ...|||||..||.||.||..|:.:||:|.|
Zfish  2162 LKDIKVFNRARQQGTNICKINNGGCQQLCLYRGNGQRTCACAHGMLAEDGQSCRDYDGYLLYSER 2226

  Fly  2316 SNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYE------EQLVYYSDVQLSTINQVHFNG 2374
            :.::|:|::|..:.|.|::...:...|:||||:|::|.      ...:::||:....|.|::.:|
Zfish  2227 TILKSVHLSDENNLNAPIKPFEDPEHMKNVIALTFDYRGGGGKGANRIFFSDIHFGNIQQINDDG 2291

  Fly  2375 TGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDK 2439
            :..:.::|....||||||....:.|:|||...:||.    ||..:.:.........|:::..||.
Zfish  2292 SDRKTVVENVGSVEGLAYHRAWDTLYWTSYTTSTIS----RHTVDQSRWGAFDRDTVVTMSGDDH 2352

  Fly  2440 PRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARL 2504
            ||...::.|..:::||||||.||.|.|:.|:|....|||.::|:.||.|.:|...:|||::||.|
Zfish  2353 PRAFVLDECQNLMFWTNWNEQSPSIMRAQLSGSNVIVIIGSEIRTPNGLAIDHRAEKLYFSDATL 2417

  Fly  2505 DKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHV-TR 2568
            |||||..|||::|.|:..:.|.|.|.:|||||.:||||||..||:||:||.|.::..||..: .:
Zfish  2418 DKIERCEYDGTHRYVVLKNEPVHPFGLAVYGDHIFWTDWVRRAVLRADKYVGGEMKVLRADIPQQ 2482

  Fly  2569 PMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSC-GL 2632
            |||||||.|.:.:|:.:.|::.||.|:|:|:|...|:..|.|.......:...|||. |||| .:
Zfish  2483 PMGIVAVANDTNSCEFSPCRVNNGGCQDLCLLTSDGRVNCSCRGERKLLEDNTCIAQ-NTSCSSM 2546

  Fly  2633 SQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCG 2697
            ..:.|.:|:||...||||.:.||.|.|||.:|||..|.|.:.:..|.|.||:.....|:|...||
Zfish  2547 EDFECGNGDCIKYTLTCDGMAHCKDKSDEKQSYCTNRVCKKGYKRCVNGRCVGHNSWCNGRDDCG 2611

  Fly  2698 DGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPI 2762
            |.|||  |.|             |.|....|.|:|..|.|:.....|:.:.||.|.|||..|:..
Zfish  2612 DNSDE--LFC-------------NATLCTADQFQCRDGVCVSNSSRCNQVLDCDDASDEMNCSAS 2661

  Fly  2763 PCEK------NDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGN 2821
            .|..      ..:|:..|..:::|..|.|.|||..||.|.:||.:|.:.....|....|.|.:|.
Zfish  2662 DCSSYFRLGVKGVTYQRCEFTSLCYAPSWVCDGANDCGDYSDERNCPDKKKRKCSSNFFACPNGR 2726

  Fly  2822 CIAGSWHCDGEKDCPDGSDEINCRTECRHNQFAC-DKTCIPASWQCDGKSDCEDGSDEGPQCPNR 2885
            ||..||.||.|.||.:|.||.:|...|...||.| :..||.:||.|||..||.||:||..:|.|:
Zfish  2727 CIPMSWTCDKENDCDNGDDEAHCDKFCSATQFECGNHRCISSSWVCDGADDCGDGTDEDSRCKNK 2791

  Fly  2886 PCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLC 2950
            .|....|||..|.:|:||:|||||::|||.|      .||..:.|.|.: ..|.....:|.:..|
Zfish  2792 TCSADAFQCPDSHKCVPQRWVCDGDRDCPDG------ADESVKAGCVFN-NTCKAGEFMCQNRQC 2849

  Fly  2951 IDSHYVCDGDEDCPGGDDEYEGC-VPAFQPHSCPGGSLMHQCQDGLCIF-KNQTCDGKPDCGDGS 3013
            |..|:|||.|.||..|.||...| .||     |.....  :|.:|.|:. |:..|||:.||.|.|
Zfish  2850 IPKHFVCDHDNDCGDGSDESVECEYPA-----CKANEF--RCDNGRCLIQKSWECDGEFDCHDHS 2907

  Fly  3014 DET--SSLCAHT--RGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIPDI--C 3072
            ||.  :..|:.|  :.||.| ::.|.||.||...|||:|.:||.|.:||..|.:||||...:  |
Zfish  2908 DEAPKNPHCSGTGEKQCNET-EYACGNGKCISESLLCNREDDCGDGTDELNCFINECLNSKLSGC 2971

  Fly  3073 EHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYAL--V 3135
            ...|||:.:|::|.|..|:: |......|.|:|||....||:|.||||:||::|:|..|:.|  .
Zfish  2972 SQLCEDQKIGFKCRCHSGFR-LKDDGKTCVDVDECSTTYPCTQHCINTHGSFRCVCVDGFQLSPS 3035

  Fly  3136 DHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINE-LSNAVALDYDWDSQCLYWSDVTSTVG 3199
            |...||:||:....|||:||||:|::::.|:...|:.: |:||||||:|:..|.:||:|||:...
Zfish  3036 DPTICKSTSDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYRQQMIYWTDVTTQGS 3100

  Fly  3200 TIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLRE 3264
            .|:|.....:..|.||:..|.||||||||||..||||||||.||||||:|:|.||.||:|..|||
Zfish  3101 MIRRMNINGSNVQVLHRTSLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVNSGLRE 3165

  Fly  3265 PRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDARED 3329
            ||.:|:.....:::||||||.||||:.||||:|..:|::|.:.|||.||:.|...:::|.|||||
Zfish  3166 PRAVAVDVRNGYLYWSDWGDIPHIGRIGMDGTNRSVIVQDKITWPNGLTLDFINDRIYWADARED 3230

  Fly  3330 TISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLIT 3394
            .|..:.|||.:...:|::.|      .||||:.::|..|||:|||||||.......|.|.:.||:
Zfish  3231 YIEFASLDGTNRHTVLSQDI------PHIFAMTLFEEFIYWTDWETKSINRAHKTQGTNKSMLIS 3289

  Fly  3395 TIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSPEEPYYKCMCPTNFILADDGRTCRAN 3457
            |:|||||:.:||||||.: :..:||...|  ||.||:|||... |||.|||||.||.||:.|.:|
Zfish  3290 TLHRPMDIHIFHPYRQPE-VPNHPCQTDNGGCSNLCLLSPGGG-YKCACPTNFYLAGDGKQCMSN 3352

  Fly  3458 CTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGIN 3522
            |||:.|.|.|. |||||:|:|||:|||||.||||..||.|.|.|||:||....||:|:.:|||.|
Zfish  3353 CTASQFVCKND-KCIPFWWKCDTEDDCGDRSDEPADCPDFKCRPGQFQCGTGICTNPAYICDGDN 3416

  Fly  3523 QCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQF 3587
            .|.|.|||.|||...|..:..||   .|.|. |:..:.||:|..:|..||||..|..:.|..:||
Zfish  3417 DCQDNSDEANCDIHVCLPSQFKC---TNPSR-CIPGIFRCNGQDNCGEGEDEKDCPEVTCAPNQF 3477

  Fly  3588 QCG-NNRCMPFVWVCDGDIDCPDKSDE-ANCDNVSCGPNDFQC-DSGRCIPLAWRCDDDHDCPNG 3649
            ||. ..||:|.|||||.|.||.|.||| |||..::||.::|:| |||||||..|:||.:.||.:.
Zfish  3478 QCTVTKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDS 3542

  Fly  3650 EDEP-ASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGK 3713
            .||| ..|  .:.||:|..|:|.|::|:||||:|||:|||||.|||..|..|.||||||.|.:|:
Zfish  3543 SDEPKEEC--DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEDKCVPRQCSESEFSCTSGR 3605

  Fly  3714 CIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNT--CINKQYKCDGDDDCPDGSDEVNC- 3775
            ||...::|||:..|.|.|||..|::.|..:||.|   |.  ||..:::||.|.||.|||||.||
Zfish  3606 CIAGRWKCDGDHDCADGSDEHGCDVKCDNDQFLC---NNGHCIPFRWRCDADADCMDGSDEENCH 3667

  Fly  3776 -----TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHC-HANAFKCRN-QLCVRN 3833
                 .|..|.|.|.|..|....|||||.|||.|.|||:.:.|.:..| .:..|:|.| ::|:..
Zfish  3668 TGVGQFCPLDEFQCNNTLCKPLGWKCDGEDDCGDNSDENPDVCKQFQCPPSRQFRCHNDRVCLPL 3732

  Fly  3834 SALCDGINDCGENEDESDAVCAALPK--CRHDQFQCENDDCISKAFRCDGQYNCVD-GSDEMNC- 3894
            |..|||:|:||:|.||.:  |...|.  |...:|.|.:..|||...||:...:|.| ||||:||
Zfish  3733 SKHCDGVNNCGDNSDEQN--CQTPPPAVCGKSEFTCSSGKCISLNLRCNFFNDCEDYGSDEINCN 3795

  Fly  3895 ----------------------------------------QPPVCG-------FGSCSQICIEKK 3912
                                                    .|..|.       ||.||.||...|
Zfish  3796 KKDSGLNECRLNRSMCGDEGHCVVNGSDSFCSCRPGFQKTHPQTCSDVNECRQFGICSHICNNTK 3860

  Fly  3913 AGHYNCKCADGYHKG-PEKNATCLASGPD-QILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKI 3975
            .|| .|.|    ||. ...|.||.|...| |.|.:|.:.|.|.:.|..|.......|....:::|
Zfish  3861 GGH-KCSC----HKNFIRVNDTCKADSSDKQALYVADDNEIRSLYPGMQNWIYEQAFQGDANVRI 3920

  Fly  3976 DVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKE----LTAFNIPELDDPKS 4036
            |..|:.|:.|  .:||.:.|.|::.:.:  .|....|.....|:.::    :|...||.|..|:.
Zfish  3921 DAMDLHIKSK--RIFWTNWHTGRISSFE--QPSAGPTSPNSNRNRRQTDPRVTDLEIPGLKMPRG 3981

  Fly  4037 LAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGM--NPTDIVLEPESRIMIWSTLEN--GI 4097
            :||||::..:|..||..:.|....:.|:...:|:| ||  .|..||::|:...|.|:...|  .|
Zfish  3982 IAVDWVANNIYWTDSGRDVIEVAQMNGRNRKTLIS-GMIDEPYAIVVDPQRGTMYWADWGNHPKI 4045

  Fly  4098 LVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKD--------RNVVR 4154
            ..|::||:.:::||..::.||..|::||...||||||.:...|.:.||||.|        :|
Zfish  4046 ETAAMDGTLRETLVHDNIQWPTGLAVDYFNERLYWADAKLSVIGSVRLNGTDPVIAVSSIKN--- 4107

  Fly  4155 RFGNREKPQKIDVFEDYLY-IKLYDQSIIKMNKFGNDNGTYLLKGY-RSSDIGILHPMKQNRNIS 4217
               |.::|..||:|||::| :..::..:.::||||..:..:|..|. .::|:.:.||.|| ..::
Zfish  4108 ---NLQQPFSIDIFEDFIYGVTYHNNFVFRVNKFGKSSVEHLTTGMNHATDLVLYHPYKQ-PEMA 4168

  Fly  4218 NPCAKDPCKSSRALCILSSESSVGYSCKCAEGYVMTDDGVCKAHADIP----------DYCPLQC 4272
            |||.:..|:   .||:||....|   |.|..|.:: |:|.|   .:||          ..|.|.|
Zfish  4169 NPCDRKKCE---WLCLLSPSGPV---CTCPNGRIL-DNGTC---VEIPAPTLSPVSPSGTCNLLC 4223

  Fly  4273 -NLGTCKI-VDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPPLKCTCTAGW 4335
             |.|||.: ...:|||.|||.:.||.||..:|.|||||.|.|:.:|
Zfish  4224 LNGGTCVLNARKLPKCRCQPNYGGERCELNQCRGYCQNGGTCTASP------------------- 4269

  Fly  4336 SGARCETSMPACQSRCHNGGSCLISETEGMKCSCPKMFTGEQCEHCRNLTCENGGICRETLTGTP 4400
                                                                         ||.|
Zfish  4270 -------------------------------------------------------------TGAP 4273

  Fly  4401 QCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTC- 4464
            .|.|..||||..|....|.::||:||:|.:|...|..|.||:.:.|:.|:..:|..||.:||||
Zfish  4274 TCRCLAGFTGPNCNQRTCENYCKSGGNCTVSRGNQPTCSCPADFLGDQCQYRTCDGFCDHGGTCL 4338

  Fly  4465 -SERGGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHII----- 4523
             |..|.| .|.||||:||.:||.|.|      |:|       ||          |.|..|
Zfish  4339 QSSDGSR-QCRCPPRFIGNNCEVDKC------HYC-------RD----------GKCIPINIYQP 4379

  Fly  4524 KGVALCNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCV 4588
            ||...|.||.......|       ..|..|||| |.|.|....||.|.|...|:|:.||.|
Zfish  4380 KGDVTCRCTSGRIQPSC-------YTCEGYCAN-GQCSLGSTNLPQCKCPLGWEGHRCENP---- 4432

  Fly  4589 GGECNVCRPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFA 4653
                                            |..|..|  .||...|:|:.|:.:||||..:..
Zfish  4433 --------------------------------ARNENAE--SSGRTASIVIPVILLILLVLLIGG 4463

  Fly  4654 GAVYFLKKHR----------IAQPFSHARLTD---NVEI-MLTNAMYRGDADE------APTFAS 4698
            .|:::.|:.|          .|:.|.|.|:|:   |||| .....:|.|:.|:      ...|..
Zfish  4464 AALWYRKRMRGLGKSRSKRPRAKGFQHQRMTNGAMNVEIGNPAYKIYEGEQDDDVGELLDADFTL 4528

  Fly  4699 EDDK-GNFANPVYESMYADAIPEPVSTEITHST-----APDERKGLLQHTHDE 4745
            :.|| .||.||||.::|..|          |::     :.||:|.||....:|
Zfish  4529 DPDKPTNFTNPVYATLYMGA----------HNSRNSLASTDEKKELLSRGDEE 4571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060	17/38 (45%)
		EGF_CA	246..283	CDD:214542	22/37 (59%)
		Ldl_recept_b	449..487	CDD:459654	15/39 (38%)
		LY	472..513	CDD:214531	20/40 (50%)
		LY	817..852	CDD:214531	12/34 (35%)
		LDLa	1057..1092	CDD:197566	16/34 (47%)
		LDLa	1104..1134	CDD:238060	16/46 (35%)
		LDLa	1191..1226	CDD:238060	15/34 (44%)
		FXa_inhibition	1289..1317	CDD:464251	14/28 (50%)
		LY	1434..1476	CDD:214531	27/41 (66%)
		LY	1477..1521	CDD:214531	32/43 (74%)
		LY	1533..1567	CDD:214531	21/33 (64%)
		LY	1568..1611	CDD:214531	23/42 (55%)
		FXa_inhibition	1639..1676	CDD:464251	18/38 (47%)
		LY	1751..1789	CDD:214531	13/39 (33%)
		LY	1794..1838	CDD:214531	13/43 (30%)
		LY	2078..2112	CDD:214531	20/33 (61%)
		NHL	<2082..>2152	CDD:302697	40/73 (55%)
		NHL repeat	2082..2120	CDD:271320	25/38 (66%)
		FXa_inhibition	2269..2303	CDD:464251	18/34 (53%)
		LY	2430..2471	CDD:214531	17/40 (43%)
		LY	2475..2517	CDD:214531	22/41 (54%)
		LDLa	2630..2661	CDD:238060	13/31 (42%)
		LDLa	2671..2702	CDD:238060	11/30 (37%)
		LDLa	2727..2759	CDD:238060	12/31 (39%)
		LDLa	2773..2802	CDD:238060	12/28 (43%)
		LDLa	2810..2844	CDD:238060	16/33 (48%)
		LDLa	2848..2878	CDD:238060	15/30 (50%)
		LDLa	2887..2916	CDD:197566	16/28 (57%)
		LDLa	2938..2969	CDD:197566	12/30 (40%)
		LDLa	2989..3015	CDD:197566	11/26 (42%)
		LDLa	3030..3061	CDD:238060	14/30 (47%)
		EGF_CA	3062..>3091	CDD:214542	11/30 (37%)
		EGF_CA	3103..3141	CDD:214542	18/39 (46%)
		LY	3212..3254	CDD:214531	30/41 (73%)
		Ldl_recept_b	3275..3314	CDD:459654	21/38 (55%)
		LY	3299..3340	CDD:214531	18/40 (45%)
		LY	3354..3389	CDD:214531	16/34 (47%)
		LDLa	3458..3490	CDD:238060	21/31 (68%)
		LDLa	3499..3533	CDD:238060	18/33 (55%)
		LDLa	3582..3616	CDD:238060	21/35 (60%)
		LDLa	3621..3652	CDD:197566	16/31 (52%)
		LDLa	3663..3697	CDD:238060	21/33 (64%)
		LDLa	3702..3736	CDD:238060	18/33 (55%)
		LDLa	3776..3808	CDD:197566	16/31 (52%)
		LDLa	3818..3849	CDD:197566	13/32 (41%)
		LDLa	3860..3894	CDD:238060	14/34 (41%)
		YncE	3935..4148	CDD:442618	68/221 (31%)
		LY	4108..4150	CDD:214531	19/49 (39%)
		EGF_CA	<4386..4414	CDD:238011	9/27 (33%)
		EGF_CA	4415..4450	CDD:238011	12/34 (35%)
lrp1aa	XP_073772278.1	None